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Gene: NKPD1 |
Gene summary for NKPD1 |
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Gene information | Species | Human | Gene symbol | NKPD1 | Gene ID | 284353 |
Gene name | NTPase KAP family P-loop domain containing 1 | |
Gene Alias | NKPD1 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284353 | NKPD1 | HCC1 | Human | Liver | HCC | 2.10e-06 | 5.36e-01 | 0.5336 |
284353 | NKPD1 | HCC2 | Human | Liver | HCC | 4.15e-09 | 6.49e-01 | 0.5341 |
284353 | NKPD1 | HCC5 | Human | Liver | HCC | 1.75e-08 | 5.18e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NKPD1 | SNV | Missense_Mutation | novel | c.686N>C | p.Arg229Thr | p.R229T | Q17RQ9 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
NKPD1 | SNV | Missense_Mutation | novel | c.1030N>A | p.Ala344Thr | p.A344T | Q17RQ9 | protein_coding | tolerated(0.39) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NKPD1 | SNV | Missense_Mutation | c.25G>A | p.Glu9Lys | p.E9K | Q17RQ9 | protein_coding | deleterious(0.01) | benign(0.018) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NKPD1 | SNV | Missense_Mutation | c.1039N>A | p.Glu347Lys | p.E347K | Q17RQ9 | protein_coding | tolerated(0.11) | benign(0.099) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
NKPD1 | SNV | Missense_Mutation | novel | c.718N>C | p.Asp240His | p.D240H | Q17RQ9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NKPD1 | SNV | Missense_Mutation | c.599N>A | p.Ser200Asn | p.S200N | Q17RQ9 | protein_coding | deleterious(0.03) | benign(0.322) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NKPD1 | SNV | Missense_Mutation | c.961N>A | p.Asp321Asn | p.D321N | Q17RQ9 | protein_coding | tolerated(0.14) | benign(0.083) | TCGA-A6-5666-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NKPD1 | SNV | Missense_Mutation | novel | c.570G>T | p.Glu190Asp | p.E190D | Q17RQ9 | protein_coding | deleterious(0.01) | possibly_damaging(0.87) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
NKPD1 | SNV | Missense_Mutation | novel | c.1436T>C | p.Leu479Pro | p.L479P | Q17RQ9 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NKPD1 | SNV | Missense_Mutation | novel | c.1010N>C | p.Lys337Thr | p.K337T | Q17RQ9 | protein_coding | tolerated(0.15) | benign(0.017) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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