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Gene: NKAIN2 |
Gene summary for NKAIN2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NKAIN2 | Gene ID | 154215 |
| Gene name | sodium/potassium transporting ATPase interacting 2 | |
| Gene Alias | FAM77B | |
| Cytomap | 6q22.31 | |
| Gene Type | protein-coding | GO ID | GO:0002028 | UniProtAcc | B3KNZ0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 154215 | NKAIN2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.21e-05 | 2.52e-01 | 0.0155 |
| 154215 | NKAIN2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.46e-10 | 5.23e-01 | -0.1808 |
| 154215 | NKAIN2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.46e-18 | 8.10e-01 | -0.0811 |
| 154215 | NKAIN2 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.61e-18 | 7.66e-01 | -0.1088 |
| 154215 | NKAIN2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.25e-06 | 3.91e-01 | -0.1954 |
| 154215 | NKAIN2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.66e-11 | 4.60e-01 | -0.1001 |
| 154215 | NKAIN2 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.39e-06 | 3.57e-01 | 0.096 |
| 154215 | NKAIN2 | F007 | Human | Colorectum | FAP | 8.01e-22 | 1.02e+00 | 0.1176 |
| 154215 | NKAIN2 | A002-C-010 | Human | Colorectum | FAP | 2.42e-12 | 5.16e-01 | 0.242 |
| 154215 | NKAIN2 | A002-C-201 | Human | Colorectum | FAP | 4.55e-05 | 4.77e-01 | 0.0324 |
| 154215 | NKAIN2 | A002-C-203 | Human | Colorectum | FAP | 3.04e-16 | 6.48e-01 | 0.2786 |
| 154215 | NKAIN2 | A008-E-015 | Human | Colorectum | FAP | 2.03e-15 | 6.06e-01 | 0.0177 |
| 154215 | NKAIN2 | F072B | Human | Colorectum | FAP | 1.81e-14 | 7.06e-01 | 0.257 |
| 154215 | NKAIN2 | CRC-1-8810 | Human | Colorectum | CRC | 3.08e-32 | 8.90e-01 | 0.6257 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0002028 | Colorectum | AD | regulation of sodium ion transport | 36/3918 | 90/18723 | 2.89e-05 | 5.37e-04 | 36 |
| GO:00020281 | Colorectum | SER | regulation of sodium ion transport | 28/2897 | 90/18723 | 1.45e-04 | 2.86e-03 | 28 |
| GO:00020284 | Colorectum | FAP | regulation of sodium ion transport | 33/2622 | 90/18723 | 6.51e-08 | 4.54e-06 | 33 |
| GO:0010959 | Colorectum | FAP | regulation of metal ion transport | 83/2622 | 406/18723 | 2.06e-04 | 2.96e-03 | 83 |
| GO:0006814 | Colorectum | FAP | sodium ion transport | 54/2622 | 245/18723 | 3.98e-04 | 4.85e-03 | 54 |
| GO:00020285 | Colorectum | CRC | regulation of sodium ion transport | 31/2078 | 90/18723 | 3.67e-09 | 9.56e-07 | 31 |
| GO:00068141 | Colorectum | CRC | sodium ion transport | 49/2078 | 245/18723 | 3.01e-05 | 7.86e-04 | 49 |
| GO:00109591 | Colorectum | CRC | regulation of metal ion transport | 69/2078 | 406/18723 | 2.05e-04 | 3.48e-03 | 69 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NKAIN2 | SNV | Missense_Mutation | c.324N>T | p.Trp108Cys | p.W108C | Q5VXU1 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
| NKAIN2 | SNV | Missense_Mutation | c.217G>A | p.Val73Ile | p.V73I | Q5VXU1 | protein_coding | tolerated(0.26) | benign(0.007) | TCGA-D8-A142-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamid | SD | |
| NKAIN2 | SNV | Missense_Mutation | c.131N>A | p.Ile44Asn | p.I44N | Q5VXU1 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-D8-A1JC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
| NKAIN2 | SNV | Missense_Mutation | c.193N>C | p.Tyr65His | p.Y65H | Q5VXU1 | protein_coding | deleterious(0.01) | benign(0.25) | TCGA-D8-A1JP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
| NKAIN2 | SNV | Missense_Mutation | rs142309299 | c.178C>T | p.Arg60Cys | p.R60C | Q5VXU1 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-JW-A69B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| NKAIN2 | SNV | Missense_Mutation | c.26N>T | p.Thr9Met | p.T9M | Q5VXU1 | protein_coding | tolerated(0.2) | probably_damaging(0.938) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| NKAIN2 | SNV | Missense_Mutation | novel | c.293C>T | p.Thr98Ile | p.T98I | Q5VXU1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| NKAIN2 | SNV | Missense_Mutation | rs748832499 | c.353N>T | p.Thr118Met | p.T118M | Q5VXU1 | protein_coding | tolerated(0.08) | probably_damaging(0.927) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| NKAIN2 | SNV | Missense_Mutation | c.121N>G | p.Phe41Val | p.F41V | Q5VXU1 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
| NKAIN2 | SNV | Missense_Mutation | rs762120533 | c.292N>G | p.Thr98Ala | p.T98A | Q5VXU1 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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