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Gene: NIPAL1 |
Gene summary for NIPAL1 |
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Gene information | Species | Human | Gene symbol | NIPAL1 | Gene ID | 152519 |
Gene name | NIPA like domain containing 1 | |
Gene Alias | NPAL1 | |
Cytomap | 4p12 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6NVV3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152519 | NIPAL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.73e-11 | -4.85e-01 | 0.0155 |
152519 | NIPAL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.40e-03 | -4.28e-01 | -0.1808 |
152519 | NIPAL1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.92e-03 | -7.02e-01 | 0.0216 |
152519 | NIPAL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.73e-07 | -5.68e-01 | -0.1207 |
152519 | NIPAL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.43e-05 | -3.68e-01 | -0.1464 |
152519 | NIPAL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.13e-06 | -3.84e-01 | -0.1001 |
152519 | NIPAL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.17e-03 | -3.54e-01 | -0.059 |
152519 | NIPAL1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.59e-02 | -5.21e-01 | -0.2061 |
152519 | NIPAL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.77e-15 | -5.88e-01 | 0.096 |
152519 | NIPAL1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.45e-09 | -6.02e-01 | 0.0338 |
152519 | NIPAL1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.81e-09 | -4.61e-01 | 0.0674 |
152519 | NIPAL1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.88e-07 | -5.79e-01 | 0.0588 |
152519 | NIPAL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.98e-15 | -5.05e-01 | 0.294 |
152519 | NIPAL1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.34e-05 | -4.27e-01 | 0.281 |
152519 | NIPAL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.82e-16 | -5.21e-01 | 0.3859 |
152519 | NIPAL1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.47e-07 | -6.41e-01 | 0.2585 |
152519 | NIPAL1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.39e-29 | -6.61e-01 | 0.3005 |
152519 | NIPAL1 | F007 | Human | Colorectum | FAP | 4.79e-08 | -4.71e-01 | 0.1176 |
152519 | NIPAL1 | A002-C-010 | Human | Colorectum | FAP | 3.73e-07 | -3.44e-01 | 0.242 |
152519 | NIPAL1 | A001-C-207 | Human | Colorectum | FAP | 9.49e-12 | -4.93e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903830 | Colorectum | FAP | magnesium ion transmembrane transport | 7/2622 | 17/18723 | 5.62e-03 | 3.61e-02 | 7 |
GO:0015693 | Colorectum | FAP | magnesium ion transport | 7/2622 | 18/18723 | 8.10e-03 | 4.77e-02 | 7 |
GO:19038301 | Colorectum | CRC | magnesium ion transmembrane transport | 7/2078 | 17/18723 | 1.46e-03 | 1.57e-02 | 7 |
GO:00156931 | Colorectum | CRC | magnesium ion transport | 7/2078 | 18/18723 | 2.16e-03 | 2.11e-02 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NIPAL1 | SNV | Missense_Mutation | c.1123N>A | p.Ala375Thr | p.A375T | Q6NVV3 | protein_coding | tolerated(0.58) | benign(0.006) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
NIPAL1 | SNV | Missense_Mutation | novel | c.720T>G | p.Ile240Met | p.I240M | Q6NVV3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NIPAL1 | SNV | Missense_Mutation | c.389N>T | p.Ala130Val | p.A130V | Q6NVV3 | protein_coding | tolerated(0.08) | benign(0.167) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NIPAL1 | insertion | Frame_Shift_Ins | novel | c.178_179insTTTTTCCTGCCATAAAACTTGGAGCATTCATGCCTGC | p.Ala60ValfsTer56 | p.A60Vfs*56 | Q6NVV3 | protein_coding | TCGA-BH-A0EB-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
NIPAL1 | SNV | Missense_Mutation | novel | c.775A>G | p.Ile259Val | p.I259V | Q6NVV3 | protein_coding | deleterious(0.03) | possibly_damaging(0.588) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NIPAL1 | SNV | Missense_Mutation | c.542N>T | p.Ser181Leu | p.S181L | Q6NVV3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
NIPAL1 | SNV | Missense_Mutation | c.796N>C | p.Glu266Gln | p.E266Q | Q6NVV3 | protein_coding | tolerated(0.61) | benign(0.043) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NIPAL1 | SNV | Missense_Mutation | c.508N>A | p.Gly170Arg | p.G170R | Q6NVV3 | protein_coding | deleterious(0.02) | probably_damaging(0.914) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
NIPAL1 | SNV | Missense_Mutation | c.538N>A | p.Gly180Arg | p.G180R | Q6NVV3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NIPAL1 | SNV | Missense_Mutation | novel | c.259N>G | p.Ile87Val | p.I87V | Q6NVV3 | protein_coding | deleterious(0.03) | benign(0.361) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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