![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NINJ2 |
Gene summary for NINJ2 |
![]() |
Gene information | Species | Human | Gene symbol | NINJ2 | Gene ID | 4815 |
Gene name | ninjurin 2 | |
Gene Alias | NINJ2 | |
Cytomap | 12p13.33 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | F8WBZ3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4815 | NINJ2 | LZE8T | Human | Esophagus | ESCC | 5.72e-05 | 2.50e-01 | 0.067 |
4815 | NINJ2 | P2T-E | Human | Esophagus | ESCC | 1.31e-06 | 1.29e-01 | 0.1177 |
4815 | NINJ2 | P4T-E | Human | Esophagus | ESCC | 1.91e-21 | 4.72e-01 | 0.1323 |
4815 | NINJ2 | P5T-E | Human | Esophagus | ESCC | 4.26e-05 | 1.05e-01 | 0.1327 |
4815 | NINJ2 | P8T-E | Human | Esophagus | ESCC | 4.32e-33 | 5.12e-01 | 0.0889 |
4815 | NINJ2 | P12T-E | Human | Esophagus | ESCC | 2.63e-16 | 2.04e-01 | 0.1122 |
4815 | NINJ2 | P15T-E | Human | Esophagus | ESCC | 4.33e-05 | 1.43e-01 | 0.1149 |
4815 | NINJ2 | P20T-E | Human | Esophagus | ESCC | 5.78e-21 | 4.88e-01 | 0.1124 |
4815 | NINJ2 | P21T-E | Human | Esophagus | ESCC | 1.08e-06 | 1.46e-01 | 0.1617 |
4815 | NINJ2 | P23T-E | Human | Esophagus | ESCC | 1.64e-07 | 2.75e-01 | 0.108 |
4815 | NINJ2 | P24T-E | Human | Esophagus | ESCC | 1.33e-08 | 2.24e-01 | 0.1287 |
4815 | NINJ2 | P27T-E | Human | Esophagus | ESCC | 7.16e-21 | 4.67e-01 | 0.1055 |
4815 | NINJ2 | P28T-E | Human | Esophagus | ESCC | 6.80e-03 | 4.01e-02 | 0.1149 |
4815 | NINJ2 | P31T-E | Human | Esophagus | ESCC | 1.23e-16 | 2.87e-01 | 0.1251 |
4815 | NINJ2 | P32T-E | Human | Esophagus | ESCC | 1.63e-04 | 8.03e-02 | 0.1666 |
4815 | NINJ2 | P36T-E | Human | Esophagus | ESCC | 6.25e-03 | 2.22e-01 | 0.1187 |
4815 | NINJ2 | P37T-E | Human | Esophagus | ESCC | 2.89e-10 | 2.13e-01 | 0.1371 |
4815 | NINJ2 | P40T-E | Human | Esophagus | ESCC | 1.67e-05 | 3.21e-01 | 0.109 |
4815 | NINJ2 | P42T-E | Human | Esophagus | ESCC | 2.35e-06 | 2.11e-01 | 0.1175 |
4815 | NINJ2 | P44T-E | Human | Esophagus | ESCC | 8.23e-04 | 1.50e-01 | 0.1096 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003109910 | Esophagus | ESCC | regeneration | 122/8552 | 198/18723 | 4.26e-06 | 4.57e-05 | 122 |
GO:00310999 | Oral cavity | OSCC | regeneration | 114/7305 | 198/18723 | 8.54e-08 | 1.50e-06 | 114 |
GO:00422464 | Oral cavity | OSCC | tissue regeneration | 42/7305 | 72/18723 | 6.89e-04 | 3.84e-03 | 42 |
GO:003109916 | Oral cavity | LP | regeneration | 76/4623 | 198/18723 | 1.25e-05 | 2.24e-04 | 76 |
GO:00422461 | Oral cavity | LP | tissue regeneration | 30/4623 | 72/18723 | 1.13e-03 | 9.27e-03 | 30 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NINJ2 | SNV | Missense_Mutation | novel | c.562N>G | p.Leu188Val | p.L188V | Q9NZG7 | protein_coding | tolerated_low_confidence(0.05) | benign(0.034) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
NINJ2 | SNV | Missense_Mutation | rs759410413 | c.134N>A | p.Ser45Asn | p.S45N | Q9NZG7 | protein_coding | tolerated(0.07) | benign(0.295) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NINJ2 | SNV | Missense_Mutation | c.205A>G | p.Asn69Asp | p.N69D | Q9NZG7 | protein_coding | tolerated(0.23) | possibly_damaging(0.557) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NINJ2 | SNV | Missense_Mutation | novel | c.23T>G | p.Leu8Arg | p.L8R | Q9NZG7 | protein_coding | deleterious_low_confidence(0) | benign(0.082) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
NINJ2 | SNV | Missense_Mutation | rs778273368 | c.514G>A | p.Gly172Arg | p.G172R | Q9NZG7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NINJ2 | SNV | Missense_Mutation | novel | c.271N>C | p.Ser91Pro | p.S91P | Q9NZG7 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NINJ2 | SNV | Missense_Mutation | rs749435320 | c.220N>A | p.Ala74Thr | p.A74T | Q9NZG7 | protein_coding | deleterious(0.01) | possibly_damaging(0.456) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
NINJ2 | SNV | Missense_Mutation | novel | c.136N>A | p.Glu46Lys | p.E46K | Q9NZG7 | protein_coding | tolerated(0.59) | benign(0) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
NINJ2 | SNV | Missense_Mutation | novel | c.487N>A | p.Val163Ile | p.V163I | Q9NZG7 | protein_coding | tolerated(0.25) | benign(0.263) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
NINJ2 | SNV | Missense_Mutation | rs561033601 | c.239C>T | p.Ala80Val | p.A80V | Q9NZG7 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |