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Gene: NIFK |
Gene summary for NIFK |
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Gene information | Species | Human | Gene symbol | NIFK | Gene ID | 84365 |
Gene name | nucleolar protein interacting with the FHA domain of MKI67 | |
Gene Alias | MKI67IP | |
Cytomap | 2q14.3 | |
Gene Type | protein-coding | GO ID | GO:0000463 | UniProtAcc | Q9BYG3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84365 | NIFK | LZE2T | Human | Esophagus | ESCC | 3.14e-02 | 8.44e-01 | 0.082 |
84365 | NIFK | LZE4T | Human | Esophagus | ESCC | 4.43e-14 | 5.15e-01 | 0.0811 |
84365 | NIFK | LZE7T | Human | Esophagus | ESCC | 1.32e-02 | 5.25e-01 | 0.0667 |
84365 | NIFK | LZE8T | Human | Esophagus | ESCC | 1.64e-10 | 1.47e-01 | 0.067 |
84365 | NIFK | LZE20T | Human | Esophagus | ESCC | 1.94e-06 | -7.30e-03 | 0.0662 |
84365 | NIFK | LZE22D1 | Human | Esophagus | HGIN | 1.81e-05 | -6.92e-02 | 0.0595 |
84365 | NIFK | LZE24T | Human | Esophagus | ESCC | 3.31e-16 | 6.10e-01 | 0.0596 |
84365 | NIFK | LZE21T | Human | Esophagus | ESCC | 8.23e-06 | 3.97e-01 | 0.0655 |
84365 | NIFK | LZE6T | Human | Esophagus | ESCC | 3.93e-02 | 1.76e-01 | 0.0845 |
84365 | NIFK | P2T-E | Human | Esophagus | ESCC | 4.96e-27 | 5.50e-01 | 0.1177 |
84365 | NIFK | P4T-E | Human | Esophagus | ESCC | 7.52e-44 | 1.46e+00 | 0.1323 |
84365 | NIFK | P5T-E | Human | Esophagus | ESCC | 1.63e-62 | 1.40e+00 | 0.1327 |
84365 | NIFK | P8T-E | Human | Esophagus | ESCC | 1.37e-22 | 5.39e-01 | 0.0889 |
84365 | NIFK | P9T-E | Human | Esophagus | ESCC | 3.40e-20 | 6.77e-01 | 0.1131 |
84365 | NIFK | P10T-E | Human | Esophagus | ESCC | 1.82e-68 | 1.53e+00 | 0.116 |
84365 | NIFK | P11T-E | Human | Esophagus | ESCC | 2.45e-11 | 9.30e-01 | 0.1426 |
84365 | NIFK | P12T-E | Human | Esophagus | ESCC | 1.14e-81 | 2.00e+00 | 0.1122 |
84365 | NIFK | P15T-E | Human | Esophagus | ESCC | 1.32e-33 | 9.32e-01 | 0.1149 |
84365 | NIFK | P16T-E | Human | Esophagus | ESCC | 3.54e-38 | 7.35e-01 | 0.1153 |
84365 | NIFK | P17T-E | Human | Esophagus | ESCC | 2.69e-07 | 5.65e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:004227326 | Esophagus | HGIN | ribosomal large subunit biogenesis | 34/2587 | 72/18723 | 8.82e-12 | 1.06e-09 | 34 |
GO:001607219 | Esophagus | HGIN | rRNA metabolic process | 72/2587 | 236/18723 | 2.26e-11 | 2.56e-09 | 72 |
GO:000636419 | Esophagus | HGIN | rRNA processing | 69/2587 | 225/18723 | 4.53e-11 | 5.04e-09 | 69 |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:00004707 | Esophagus | HGIN | maturation of LSU-rRNA | 10/2587 | 28/18723 | 3.04e-03 | 2.88e-02 | 10 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042273111 | Esophagus | ESCC | ribosomal large subunit biogenesis | 65/8552 | 72/18723 | 1.53e-15 | 9.82e-14 | 65 |
GO:000047016 | Esophagus | ESCC | maturation of LSU-rRNA | 27/8552 | 28/18723 | 9.94e-09 | 2.00e-07 | 27 |
GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
GO:00004634 | Esophagus | ESCC | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 15/8552 | 15/18723 | 7.81e-06 | 7.69e-05 | 15 |
GO:00093032 | Esophagus | ESCC | rRNA transcription | 28/8552 | 34/18723 | 1.21e-05 | 1.12e-04 | 28 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NIFK | SNV | Missense_Mutation | novel | c.233N>C | p.Arg78Thr | p.R78T | Q9BYG3 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NIFK | SNV | Missense_Mutation | novel | c.149G>A | p.Arg50His | p.R50H | Q9BYG3 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NIFK | SNV | Missense_Mutation | rs756299604 | c.760N>A | p.Asp254Asn | p.D254N | Q9BYG3 | protein_coding | tolerated(0.05) | possibly_damaging(0.565) | TCGA-VS-A9U7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NIFK | SNV | Missense_Mutation | c.403N>C | p.Asn135His | p.N135H | Q9BYG3 | protein_coding | tolerated(0.3) | benign(0.005) | TCGA-A6-6650-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NIFK | SNV | Missense_Mutation | rs182886627 | c.148C>T | p.Arg50Cys | p.R50C | Q9BYG3 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NIFK | SNV | Missense_Mutation | novel | c.357N>G | p.His119Gln | p.H119Q | Q9BYG3 | protein_coding | tolerated(0.42) | benign(0.068) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NIFK | SNV | Missense_Mutation | c.302N>C | p.Ile101Thr | p.I101T | Q9BYG3 | protein_coding | deleterious(0.01) | possibly_damaging(0.824) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NIFK | insertion | Frame_Shift_Ins | novel | c.124_125insCCTT | p.Leu42ProfsTer14 | p.L42Pfs*14 | Q9BYG3 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NIFK | insertion | Frame_Shift_Ins | novel | c.122_123insTCTT | p.Gln41HisfsTer15 | p.Q41Hfs*15 | Q9BYG3 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NIFK | deletion | Frame_Shift_Del | c.537delA | p.Gly180GlufsTer9 | p.G180Efs*9 | Q9BYG3 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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