Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: NHS

Gene summary for NHS

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

NHS

Gene ID

4810

Gene nameNHS actin remodeling regulator
Gene AliasCTRCT40
CytomapXp22.2-p22.13
Gene Typeprotein-coding
GO ID

GO:0001654

UniProtAcc

Q6T4R5


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4810NHSCCI_1HumanCervixCC6.42e-045.73e-010.528
4810NHSCCI_2HumanCervixCC1.68e-087.46e-010.5249
4810NHSCCI_3HumanCervixCC3.40e-168.11e-010.516
4810NHSHTA11_3361_2000001011HumanColorectumAD4.17e-02-3.99e-01-0.1207
4810NHSHTA11_696_2000001011HumanColorectumAD6.59e-05-2.93e-01-0.1464
4810NHSHTA11_866_2000001011HumanColorectumAD3.39e-02-2.46e-01-0.1001
4810NHSHTA11_99999971662_82457HumanColorectumMSS3.98e-06-2.88e-010.3859
4810NHSA015-C-203HumanColorectumFAP1.55e-08-2.26e-01-0.1294
4810NHSA002-C-203HumanColorectumFAP2.38e-055.32e-010.2786
4810NHSA001-C-108HumanColorectumFAP2.26e-037.67e-02-0.0272
4810NHSA002-C-205HumanColorectumFAP1.17e-04-2.10e-01-0.1236
4810NHSA015-C-006HumanColorectumFAP3.32e-02-3.20e-02-0.0994
4810NHSA002-C-114HumanColorectumFAP1.15e-03-2.86e-01-0.1561
4810NHSA015-C-104HumanColorectumFAP4.16e-12-3.13e-01-0.1899
4810NHSA001-C-014HumanColorectumFAP3.64e-027.85e-030.0135
4810NHSA002-C-016HumanColorectumFAP1.25e-07-4.38e-020.0521
4810NHSA001-C-203HumanColorectumFAP7.89e-03-8.55e-03-0.0481
4810NHSA002-C-116HumanColorectumFAP1.19e-12-1.35e-01-0.0452
4810NHSA018-E-020HumanColorectumFAP8.43e-04-2.62e-01-0.2034
4810NHSF034HumanColorectumFAP4.39e-04-5.44e-02-0.0665
Page: 1 2 3 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0150063CervixCCvisual system development63/2311375/187236.58e-033.65e-0263
GO:0001654CervixCCeye development62/2311371/187237.83e-034.13e-0262
GO:0048880CervixCCsensory system development63/2311381/187239.29e-034.66e-0263
Page: 1 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
NHSSNVMissense_Mutationc.4144N>Ap.Glu1382Lysp.E1382KQ6T4R5protein_codingdeleterious(0.03)benign(0.218)TCGA-A2-A0SY-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyarimidexSD
NHSSNVMissense_Mutationc.3029N>Tp.Thr1010Metp.T1010MQ6T4R5protein_codingdeleterious(0.02)probably_damaging(0.999)TCGA-A8-A08T-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
NHSSNVMissense_Mutationnovelc.999A>Cp.Gln333Hisp.Q333HQ6T4R5protein_codingdeleterious(0.01)probably_damaging(0.997)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
NHSSNVMissense_Mutationnovelc.3113G>Tp.Arg1038Ilep.R1038IQ6T4R5protein_codingdeleterious(0)probably_damaging(0.997)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
NHSSNVMissense_Mutationrs145005596c.3311C>Tp.Ser1104Leup.S1104LQ6T4R5protein_codingtolerated(0.08)benign(0.254)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
NHSSNVMissense_Mutationrs745597127c.1772C>Tp.Thr591Metp.T591MQ6T4R5protein_codingdeleterious(0.02)probably_damaging(0.966)TCGA-AN-A0FS-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
NHSSNVMissense_Mutationc.617C>Tp.Pro206Leup.P206LQ6T4R5protein_codingdeleterious(0)possibly_damaging(0.67)TCGA-AR-A24O-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanPD
NHSSNVMissense_Mutationnovelc.897G>Cp.Gln299Hisp.Q299HQ6T4R5protein_codingtolerated(0.52)probably_damaging(0.997)TCGA-BH-A0HP-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapydoxorubicinSD
NHSSNVMissense_Mutationc.4541N>Tp.Ser1514Phep.S1514FQ6T4R5protein_codingdeleterious(0)probably_damaging(0.999)TCGA-D8-A1JK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
NHSSNVMissense_Mutationc.1355N>Ap.Ala452Glup.A452EQ6T4R5protein_codingdeleterious(0)possibly_damaging(0.773)TCGA-D8-A1X9-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapyadriamycin+cyclophosphamideSD
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1