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Gene: NHEJ1 |
Gene summary for NHEJ1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NHEJ1 | Gene ID | 79840 |
| Gene name | non-homologous end joining factor 1 | |
| Gene Alias | XLF | |
| Cytomap | 2q35 | |
| Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9H9Q4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79840 | NHEJ1 | LZE24T | Human | Esophagus | ESCC | 3.74e-07 | 2.12e-01 | 0.0596 |
| 79840 | NHEJ1 | LZE6T | Human | Esophagus | ESCC | 1.62e-02 | 1.39e-01 | 0.0845 |
| 79840 | NHEJ1 | P2T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.23e-01 | 0.1177 |
| 79840 | NHEJ1 | P4T-E | Human | Esophagus | ESCC | 1.75e-05 | 1.63e-01 | 0.1323 |
| 79840 | NHEJ1 | P5T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.59e-01 | 0.1327 |
| 79840 | NHEJ1 | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.78e-02 | 0.0889 |
| 79840 | NHEJ1 | P10T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.13e-01 | 0.116 |
| 79840 | NHEJ1 | P11T-E | Human | Esophagus | ESCC | 6.08e-06 | 2.66e-01 | 0.1426 |
| 79840 | NHEJ1 | P12T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.01e-01 | 0.1122 |
| 79840 | NHEJ1 | P15T-E | Human | Esophagus | ESCC | 6.21e-15 | 3.31e-01 | 0.1149 |
| 79840 | NHEJ1 | P16T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.51e-01 | 0.1153 |
| 79840 | NHEJ1 | P17T-E | Human | Esophagus | ESCC | 7.64e-08 | 3.00e-01 | 0.1278 |
| 79840 | NHEJ1 | P20T-E | Human | Esophagus | ESCC | 7.88e-10 | 2.44e-01 | 0.1124 |
| 79840 | NHEJ1 | P21T-E | Human | Esophagus | ESCC | 1.62e-13 | 3.04e-01 | 0.1617 |
| 79840 | NHEJ1 | P22T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.18e-01 | 0.1236 |
| 79840 | NHEJ1 | P23T-E | Human | Esophagus | ESCC | 1.78e-18 | 3.56e-01 | 0.108 |
| 79840 | NHEJ1 | P24T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.67e-01 | 0.1287 |
| 79840 | NHEJ1 | P26T-E | Human | Esophagus | ESCC | 5.00e-17 | 3.06e-01 | 0.1276 |
| 79840 | NHEJ1 | P27T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.13e-01 | 0.1055 |
| 79840 | NHEJ1 | P28T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.04e-01 | 0.1149 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001021217 | Esophagus | ESCC | response to ionizing radiation | 110/8552 | 148/18723 | 1.11e-12 | 4.78e-11 | 110 |
| GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
| GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
| GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
| GO:00025622 | Esophagus | ESCC | somatic diversification of immune receptors via germline recombination within a single locus | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
| GO:0006303 | Esophagus | ESCC | double-strand break repair via nonhomologous end joining | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
| GO:00164442 | Esophagus | ESCC | somatic cell DNA recombination | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
| GO:00164472 | Esophagus | ESCC | somatic recombination of immunoglobulin gene segments | 38/8552 | 57/18723 | 1.11e-03 | 5.56e-03 | 38 |
| GO:00022003 | Esophagus | ESCC | somatic diversification of immune receptors | 49/8552 | 77/18723 | 1.12e-03 | 5.60e-03 | 49 |
| GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
| GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
| GO:00164452 | Esophagus | ESCC | somatic diversification of immunoglobulins | 43/8552 | 67/18723 | 1.73e-03 | 7.97e-03 | 43 |
| GO:00062661 | Esophagus | ESCC | DNA ligation | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
| GO:00302176 | Esophagus | ESCC | T cell differentiation | 137/8552 | 257/18723 | 8.09e-03 | 2.87e-02 | 137 |
| GO:00300984 | Esophagus | ESCC | lymphocyte differentiation | 192/8552 | 374/18723 | 1.52e-02 | 4.93e-02 | 192 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NHEJ1 | insertion | Frame_Shift_Ins | novel | c.221_222insGGTTTCATCACGTTTCCCAGGCTGGACT | p.Cys74TrpfsTer14 | p.C74Wfs*14 | Q9H9Q4 | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
| NHEJ1 | insertion | In_Frame_Ins | novel | c.463_464insTTCTCTACTCTTCTCTCCTCTTCTCTTCTCTTCTCTTCCCTG | p.Thr155delinsIleLeuTyrSerSerLeuLeuPheSerSerLeuLeuPheProAla | p.T155delinsILYSSLLFSSLLFPA | Q9H9Q4 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| NHEJ1 | deletion | Frame_Shift_Del | novel | c.375delN | p.Ala126LeufsTer10 | p.A126Lfs*10 | Q9H9Q4 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| NHEJ1 | SNV | Missense_Mutation | rs777365329 | c.326G>A | p.Arg109Gln | p.R109Q | Q9H9Q4 | protein_coding | deleterious(0.04) | benign(0.053) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| NHEJ1 | SNV | Missense_Mutation | c.628N>G | p.Phe210Val | p.F210V | Q9H9Q4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| NHEJ1 | SNV | Missense_Mutation | rs770861190 | c.518N>T | p.Thr173Met | p.T173M | Q9H9Q4 | protein_coding | deleterious(0.04) | benign(0.14) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
| NHEJ1 | SNV | Missense_Mutation | c.690G>T | p.Gln230His | p.Q230H | Q9H9Q4 | protein_coding | deleterious(0.03) | benign(0.261) | TCGA-D5-6898-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| NHEJ1 | SNV | Missense_Mutation | novel | c.533N>A | p.Arg178Gln | p.R178Q | Q9H9Q4 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| NHEJ1 | SNV | Missense_Mutation | c.338N>A | p.Ser113Tyr | p.S113Y | Q9H9Q4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| NHEJ1 | SNV | Missense_Mutation | novel | c.885G>T | p.Arg295Ser | p.R295S | Q9H9Q4 | protein_coding | deleterious(0.01) | benign(0.214) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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