Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: NFU1

Gene summary for NFU1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

NFU1

Gene ID

27247

Gene nameNFU1 iron-sulfur cluster scaffold
Gene AliasCGI-33
Cytomap2p13.3
Gene Typeprotein-coding
GO ID

GO:0006790

UniProtAcc

Q9UMS0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
27247NFU1LZE3DHumanEsophagusHGIN4.39e-025.67e-010.0668
27247NFU1LZE4THumanEsophagusESCC5.25e-194.74e-010.0811
27247NFU1LZE7THumanEsophagusESCC3.54e-073.04e-010.0667
27247NFU1LZE8THumanEsophagusESCC1.99e-102.66e-010.067
27247NFU1LZE22THumanEsophagusESCC1.04e-043.30e-010.068
27247NFU1LZE24THumanEsophagusESCC2.27e-133.96e-010.0596
27247NFU1LZE21THumanEsophagusESCC1.39e-021.43e-010.0655
27247NFU1LZE6THumanEsophagusESCC3.68e-074.68e-010.0845
27247NFU1P1T-EHumanEsophagusESCC1.08e-033.20e-010.0875
27247NFU1P2T-EHumanEsophagusESCC1.28e-345.47e-010.1177
27247NFU1P4T-EHumanEsophagusESCC1.90e-267.35e-010.1323
27247NFU1P5T-EHumanEsophagusESCC1.57e-112.68e-010.1327
27247NFU1P8T-EHumanEsophagusESCC1.81e-265.19e-010.0889
27247NFU1P9T-EHumanEsophagusESCC3.20e-164.36e-010.1131
27247NFU1P10T-EHumanEsophagusESCC2.72e-233.61e-010.116
27247NFU1P11T-EHumanEsophagusESCC4.49e-126.67e-010.1426
27247NFU1P12T-EHumanEsophagusESCC1.54e-418.50e-010.1122
27247NFU1P15T-EHumanEsophagusESCC2.57e-348.83e-010.1149
27247NFU1P16T-EHumanEsophagusESCC4.61e-285.99e-010.1153
27247NFU1P17T-EHumanEsophagusESCC1.68e-023.72e-010.1278
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:005160418EsophagusESCCprotein maturation189/8552294/187237.64e-112.39e-09189
GO:00067906EsophagusESCCsulfur compound metabolic process201/8552339/187232.64e-073.94e-06201
GO:001622611EsophagusESCCiron-sulfur cluster assembly21/855226/187232.69e-041.63e-0321
GO:003116311EsophagusESCCmetallo-sulfur cluster assembly21/855226/187232.69e-041.63e-0321
GO:009742811EsophagusESCCprotein maturation by iron-sulfur cluster transfer14/855216/187236.78e-043.56e-0314
GO:00516046LiverCirrhoticprotein maturation121/4634294/187233.54e-101.68e-08121
GO:000679011LiverCirrhoticsulfur compound metabolic process129/4634339/187233.06e-081.04e-06129
GO:000679021LiverHCCsulfur compound metabolic process212/7958339/187235.60e-143.39e-12212
GO:005160412LiverHCCprotein maturation171/7958294/187233.80e-088.30e-07171
GO:0016226LiverHCCiron-sulfur cluster assembly18/795826/187235.37e-032.24e-0218
GO:0031163LiverHCCmetallo-sulfur cluster assembly18/795826/187235.37e-032.24e-0218
GO:005160410Oral cavityOSCCprotein maturation170/7305294/187233.97e-111.28e-09170
GO:00067905Oral cavityOSCCsulfur compound metabolic process168/7305339/187234.50e-053.84e-04168
GO:00162262Oral cavityOSCCiron-sulfur cluster assembly19/730526/187234.46e-042.70e-0319
GO:00311632Oral cavityOSCCmetallo-sulfur cluster assembly19/730526/187234.46e-042.70e-0319
GO:0097428Oral cavityOSCCprotein maturation by iron-sulfur cluster transfer11/730516/187231.56e-024.99e-0211
GO:005160416Oral cavityLPprotein maturation122/4623294/187231.37e-107.72e-09122
GO:00162261Oral cavityLPiron-sulfur cluster assembly15/462326/187233.34e-043.34e-0315
GO:00311631Oral cavityLPmetallo-sulfur cluster assembly15/462326/187233.34e-043.34e-0315
GO:000679012Oral cavityLPsulfur compound metabolic process106/4623339/187233.36e-032.25e-02106
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
NFU1SNVMissense_Mutationc.473N>Tp.Ser158Leup.S158LQ9UMS0protein_codingtolerated(0.11)benign(0.027)TCGA-AC-A5XS-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyfemaraSD
NFU1SNVMissense_Mutationc.516G>Ap.Met172Ilep.M172IQ9UMS0protein_codingdeleterious(0.03)possibly_damaging(0.566)TCGA-IR-A3LL-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
NFU1SNVMissense_Mutationnovelc.748N>Cp.Glu250Glnp.E250QQ9UMS0protein_codingtolerated(0.14)benign(0.003)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
NFU1SNVMissense_Mutationc.354C>Ap.Phe118Leup.F118LQ9UMS0protein_codingdeleterious(0)probably_damaging(0.994)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
NFU1SNVMissense_Mutationc.163N>Tp.Pro55Serp.P55SQ9UMS0protein_codingtolerated(0.56)benign(0.001)TCGA-AG-A00Y-01Colorectumrectum adenocarcinomaMale>=65I/IIUnknownUnknownPD
NFU1SNVMissense_Mutationc.545N>Ap.Arg182Glnp.R182QQ9UMS0protein_codingdeleterious(0)probably_damaging(0.983)TCGA-A5-A2K7-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapytaxolSD
NFU1SNVMissense_Mutationnovelc.328N>Cp.Lys110Glnp.K110QQ9UMS0protein_codingtolerated(0.06)possibly_damaging(0.733)TCGA-AX-A06F-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinSD
NFU1SNVMissense_Mutationc.339N>Ap.Phe113Leup.F113LQ9UMS0protein_codingdeleterious(0.03)possibly_damaging(0.859)TCGA-B5-A0JY-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapydoxorubicinSD
NFU1SNVMissense_Mutationnovelc.143T>Cp.Leu48Prop.L48PQ9UMS0protein_codingtolerated(0.28)benign(0)TCGA-B5-A1MX-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIHormone TherapymegaceSD
NFU1SNVMissense_Mutationnovelc.599N>Tp.Gly200Valp.G200VQ9UMS0protein_codingdeleterious(0)probably_damaging(1)TCGA-B5-A3FA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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