|
Gene: NFU1 |
Gene summary for NFU1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NFU1 | Gene ID | 27247 |
Gene name | NFU1 iron-sulfur cluster scaffold | |
Gene Alias | CGI-33 | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006790 | UniProtAcc | Q9UMS0 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27247 | NFU1 | LZE3D | Human | Esophagus | HGIN | 4.39e-02 | 5.67e-01 | 0.0668 |
27247 | NFU1 | LZE4T | Human | Esophagus | ESCC | 5.25e-19 | 4.74e-01 | 0.0811 |
27247 | NFU1 | LZE7T | Human | Esophagus | ESCC | 3.54e-07 | 3.04e-01 | 0.0667 |
27247 | NFU1 | LZE8T | Human | Esophagus | ESCC | 1.99e-10 | 2.66e-01 | 0.067 |
27247 | NFU1 | LZE22T | Human | Esophagus | ESCC | 1.04e-04 | 3.30e-01 | 0.068 |
27247 | NFU1 | LZE24T | Human | Esophagus | ESCC | 2.27e-13 | 3.96e-01 | 0.0596 |
27247 | NFU1 | LZE21T | Human | Esophagus | ESCC | 1.39e-02 | 1.43e-01 | 0.0655 |
27247 | NFU1 | LZE6T | Human | Esophagus | ESCC | 3.68e-07 | 4.68e-01 | 0.0845 |
27247 | NFU1 | P1T-E | Human | Esophagus | ESCC | 1.08e-03 | 3.20e-01 | 0.0875 |
27247 | NFU1 | P2T-E | Human | Esophagus | ESCC | 1.28e-34 | 5.47e-01 | 0.1177 |
27247 | NFU1 | P4T-E | Human | Esophagus | ESCC | 1.90e-26 | 7.35e-01 | 0.1323 |
27247 | NFU1 | P5T-E | Human | Esophagus | ESCC | 1.57e-11 | 2.68e-01 | 0.1327 |
27247 | NFU1 | P8T-E | Human | Esophagus | ESCC | 1.81e-26 | 5.19e-01 | 0.0889 |
27247 | NFU1 | P9T-E | Human | Esophagus | ESCC | 3.20e-16 | 4.36e-01 | 0.1131 |
27247 | NFU1 | P10T-E | Human | Esophagus | ESCC | 2.72e-23 | 3.61e-01 | 0.116 |
27247 | NFU1 | P11T-E | Human | Esophagus | ESCC | 4.49e-12 | 6.67e-01 | 0.1426 |
27247 | NFU1 | P12T-E | Human | Esophagus | ESCC | 1.54e-41 | 8.50e-01 | 0.1122 |
27247 | NFU1 | P15T-E | Human | Esophagus | ESCC | 2.57e-34 | 8.83e-01 | 0.1149 |
27247 | NFU1 | P16T-E | Human | Esophagus | ESCC | 4.61e-28 | 5.99e-01 | 0.1153 |
27247 | NFU1 | P17T-E | Human | Esophagus | ESCC | 1.68e-02 | 3.72e-01 | 0.1278 |
Page: 1 2 3 4 5 6 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:001622611 | Esophagus | ESCC | iron-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:003116311 | Esophagus | ESCC | metallo-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:009742811 | Esophagus | ESCC | protein maturation by iron-sulfur cluster transfer | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:0016226 | Liver | HCC | iron-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:0031163 | Liver | HCC | metallo-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:00067905 | Oral cavity | OSCC | sulfur compound metabolic process | 168/7305 | 339/18723 | 4.50e-05 | 3.84e-04 | 168 |
GO:00162262 | Oral cavity | OSCC | iron-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:00311632 | Oral cavity | OSCC | metallo-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:0097428 | Oral cavity | OSCC | protein maturation by iron-sulfur cluster transfer | 11/7305 | 16/18723 | 1.56e-02 | 4.99e-02 | 11 |
GO:005160416 | Oral cavity | LP | protein maturation | 122/4623 | 294/18723 | 1.37e-10 | 7.72e-09 | 122 |
GO:00162261 | Oral cavity | LP | iron-sulfur cluster assembly | 15/4623 | 26/18723 | 3.34e-04 | 3.34e-03 | 15 |
GO:00311631 | Oral cavity | LP | metallo-sulfur cluster assembly | 15/4623 | 26/18723 | 3.34e-04 | 3.34e-03 | 15 |
GO:000679012 | Oral cavity | LP | sulfur compound metabolic process | 106/4623 | 339/18723 | 3.36e-03 | 2.25e-02 | 106 |
Page: 1 2 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFU1 | SNV | Missense_Mutation | c.473N>T | p.Ser158Leu | p.S158L | Q9UMS0 | protein_coding | tolerated(0.11) | benign(0.027) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD | |
NFU1 | SNV | Missense_Mutation | c.516G>A | p.Met172Ile | p.M172I | Q9UMS0 | protein_coding | deleterious(0.03) | possibly_damaging(0.566) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NFU1 | SNV | Missense_Mutation | novel | c.748N>C | p.Glu250Gln | p.E250Q | Q9UMS0 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NFU1 | SNV | Missense_Mutation | c.354C>A | p.Phe118Leu | p.F118L | Q9UMS0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NFU1 | SNV | Missense_Mutation | c.163N>T | p.Pro55Ser | p.P55S | Q9UMS0 | protein_coding | tolerated(0.56) | benign(0.001) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NFU1 | SNV | Missense_Mutation | c.545N>A | p.Arg182Gln | p.R182Q | Q9UMS0 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
NFU1 | SNV | Missense_Mutation | novel | c.328N>C | p.Lys110Gln | p.K110Q | Q9UMS0 | protein_coding | tolerated(0.06) | possibly_damaging(0.733) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
NFU1 | SNV | Missense_Mutation | c.339N>A | p.Phe113Leu | p.F113L | Q9UMS0 | protein_coding | deleterious(0.03) | possibly_damaging(0.859) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
NFU1 | SNV | Missense_Mutation | novel | c.143T>C | p.Leu48Pro | p.L48P | Q9UMS0 | protein_coding | tolerated(0.28) | benign(0) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
NFU1 | SNV | Missense_Mutation | novel | c.599N>T | p.Gly200Val | p.G200V | Q9UMS0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |