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Gene: NFAM1 |
Gene summary for NFAM1 |
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Gene information | Species | Human | Gene symbol | NFAM1 | Gene ID | 150372 |
Gene name | NFAT activating protein with ITAM motif 1 | |
Gene Alias | CNAIP | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q8NET5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
150372 | NFAM1 | HCC1 | Human | Liver | HCC | 1.11e-05 | 1.06e+00 | 0.5336 |
150372 | NFAM1 | HCC2 | Human | Liver | HCC | 1.04e-18 | 1.57e+00 | 0.5341 |
150372 | NFAM1 | HCC5 | Human | Liver | HCC | 1.18e-06 | 7.05e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510902 | Liver | HCC | regulation of DNA-binding transcription factor activity | 220/7958 | 440/18723 | 8.04e-04 | 4.82e-03 | 220 |
GO:00510913 | Liver | HCC | positive regulation of DNA-binding transcription factor activity | 131/7958 | 260/18723 | 5.98e-03 | 2.45e-02 | 131 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFAM1 | SNV | Missense_Mutation | c.569G>A | p.Arg190Gln | p.R190Q | Q8NET5 | protein_coding | tolerated(1) | benign(0) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NFAM1 | SNV | Missense_Mutation | novel | c.796N>T | p.Val266Phe | p.V266F | Q8NET5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFAM1 | SNV | Missense_Mutation | rs771852404 | c.49N>T | p.Pro17Ser | p.P17S | Q8NET5 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.653) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFAM1 | SNV | Missense_Mutation | rs145224229 | c.784G>A | p.Glu262Lys | p.E262K | Q8NET5 | protein_coding | deleterious(0.01) | benign(0.046) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFAM1 | SNV | Missense_Mutation | novel | c.176N>T | p.Thr59Ile | p.T59I | Q8NET5 | protein_coding | tolerated(0.18) | benign(0.075) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFAM1 | SNV | Missense_Mutation | rs577425190 | c.367N>A | p.Ala123Thr | p.A123T | Q8NET5 | protein_coding | tolerated(0.13) | benign(0.117) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFAM1 | SNV | Missense_Mutation | rs200499062 | c.772N>A | p.Glu258Lys | p.E258K | Q8NET5 | protein_coding | tolerated(0.19) | benign(0.007) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NFAM1 | SNV | Missense_Mutation | rs550916047 | c.653N>A | p.Ser218Tyr | p.S218Y | Q8NET5 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NFAM1 | SNV | Missense_Mutation | rs142903439 | c.454G>A | p.Ala152Thr | p.A152T | Q8NET5 | protein_coding | tolerated(1) | benign(0) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFAM1 | insertion | Frame_Shift_Ins | novel | c.745_746insC | p.Leu249ProfsTer8 | p.L249Pfs*8 | Q8NET5 | protein_coding | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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