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Gene: NEXN |
Gene summary for NEXN |
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Gene information | Species | Human | Gene symbol | NEXN | Gene ID | 91624 |
Gene name | nexilin F-actin binding protein | |
Gene Alias | CMH20 | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | B4DDI0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91624 | NEXN | P2T-E | Human | Esophagus | ESCC | 3.49e-08 | 1.76e-01 | 0.1177 |
91624 | NEXN | P4T-E | Human | Esophagus | ESCC | 1.87e-02 | 2.85e-01 | 0.1323 |
91624 | NEXN | P9T-E | Human | Esophagus | ESCC | 2.37e-05 | 3.60e-01 | 0.1131 |
91624 | NEXN | P44T-E | Human | Esophagus | ESCC | 6.24e-03 | 2.08e-01 | 0.1096 |
91624 | NEXN | P52T-E | Human | Esophagus | ESCC | 1.19e-02 | 2.32e-01 | 0.1555 |
91624 | NEXN | P62T-E | Human | Esophagus | ESCC | 1.87e-23 | 5.30e-01 | 0.1302 |
91624 | NEXN | P74T-E | Human | Esophagus | ESCC | 8.91e-05 | 2.33e-01 | 0.1479 |
91624 | NEXN | P75T-E | Human | Esophagus | ESCC | 1.04e-06 | 2.21e-01 | 0.1125 |
91624 | NEXN | P79T-E | Human | Esophagus | ESCC | 1.22e-23 | 8.18e-01 | 0.1154 |
91624 | NEXN | P80T-E | Human | Esophagus | ESCC | 2.09e-26 | 7.40e-01 | 0.155 |
91624 | NEXN | P89T-E | Human | Esophagus | ESCC | 5.20e-06 | 3.21e-01 | 0.1752 |
91624 | NEXN | P91T-E | Human | Esophagus | ESCC | 4.04e-10 | 1.17e+00 | 0.1828 |
91624 | NEXN | P130T-E | Human | Esophagus | ESCC | 6.93e-31 | 6.81e-01 | 0.1676 |
91624 | NEXN | PTC01 | Human | Thyroid | PTC | 2.76e-02 | -1.45e-02 | 0.1899 |
91624 | NEXN | ATC11 | Human | Thyroid | ATC | 3.67e-12 | 1.44e+00 | 0.3386 |
91624 | NEXN | ATC12 | Human | Thyroid | ATC | 8.17e-06 | 3.03e-01 | 0.34 |
91624 | NEXN | ATC13 | Human | Thyroid | ATC | 4.01e-52 | 1.13e+00 | 0.34 |
91624 | NEXN | ATC2 | Human | Thyroid | ATC | 3.54e-12 | 1.52e+00 | 0.34 |
91624 | NEXN | ATC3 | Human | Thyroid | ATC | 1.07e-17 | 1.32e+00 | 0.338 |
91624 | NEXN | ATC4 | Human | Thyroid | ATC | 1.06e-12 | 3.83e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006156415 | Esophagus | ESCC | axon development | 251/8552 | 467/18723 | 2.41e-04 | 1.49e-03 | 251 |
GO:000740915 | Esophagus | ESCC | axonogenesis | 219/8552 | 418/18723 | 3.14e-03 | 1.31e-02 | 219 |
GO:006156419 | Thyroid | PTC | axon development | 199/5968 | 467/18723 | 5.27e-07 | 8.53e-06 | 199 |
GO:000740918 | Thyroid | PTC | axonogenesis | 178/5968 | 418/18723 | 2.17e-06 | 2.91e-05 | 178 |
GO:006156423 | Thyroid | ATC | axon development | 220/6293 | 467/18723 | 6.85e-10 | 1.80e-08 | 220 |
GO:000740919 | Thyroid | ATC | axonogenesis | 197/6293 | 418/18723 | 5.09e-09 | 1.13e-07 | 197 |
GO:00074113 | Thyroid | ATC | axon guidance | 96/6293 | 227/18723 | 3.74e-03 | 1.63e-02 | 96 |
GO:00974853 | Thyroid | ATC | neuron projection guidance | 96/6293 | 228/18723 | 4.36e-03 | 1.81e-02 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NEXN | SNV | Missense_Mutation | novel | c.1261N>C | p.Glu421Gln | p.E421Q | Q0ZGT2 | protein_coding | tolerated(0.15) | possibly_damaging(0.663) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
NEXN | SNV | Missense_Mutation | c.1069N>C | p.Ser357Pro | p.S357P | Q0ZGT2 | protein_coding | tolerated(0.08) | benign(0.043) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEXN | SNV | Missense_Mutation | c.728C>A | p.Ser243Tyr | p.S243Y | Q0ZGT2 | protein_coding | tolerated(0.1) | benign(0.157) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEXN | SNV | Missense_Mutation | c.7G>A | p.Asp3Asn | p.D3N | Q0ZGT2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.864) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
NEXN | SNV | Missense_Mutation | rs775423327 | c.1772C>T | p.Thr591Ile | p.T591I | Q0ZGT2 | protein_coding | tolerated(0.56) | benign(0.17) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NEXN | SNV | Missense_Mutation | c.967N>C | p.Glu323Gln | p.E323Q | Q0ZGT2 | protein_coding | deleterious(0.02) | benign(0.179) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NEXN | insertion | Nonsense_Mutation | novel | c.214_215insTAAAAATTAAAATATATATATA | p.Gln72LeufsTer8 | p.Q72Lfs*8 | Q0ZGT2 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
NEXN | SNV | Missense_Mutation | novel | c.25N>C | p.Glu9Gln | p.E9Q | Q0ZGT2 | protein_coding | tolerated(0.15) | benign(0.251) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
NEXN | SNV | Missense_Mutation | novel | c.847G>C | p.Glu283Gln | p.E283Q | Q0ZGT2 | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
NEXN | SNV | Missense_Mutation | c.626G>T | p.Arg209Ile | p.R209I | Q0ZGT2 | protein_coding | deleterious(0.04) | benign(0.051) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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