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Gene: NEURL1B |
Gene summary for NEURL1B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NEURL1B | Gene ID | 54492 |
| Gene name | neuralized E3 ubiquitin protein ligase 1B | |
| Gene Alias | NEURL3 | |
| Cytomap | 5q35.1 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A8MQ27 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 54492 | NEURL1B | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.72e-03 | 2.96e-01 | -0.1808 |
| 54492 | NEURL1B | HTA11_347_2000001011 | Human | Colorectum | AD | 5.67e-23 | 7.15e-01 | -0.1954 |
| 54492 | NEURL1B | HTA11_411_2000001011 | Human | Colorectum | SER | 2.67e-02 | 5.82e-01 | -0.2602 |
| 54492 | NEURL1B | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.16e-03 | 8.25e-01 | -0.2196 |
| 54492 | NEURL1B | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.39e-04 | 4.69e-01 | -0.1207 |
| 54492 | NEURL1B | HTA11_83_2000001011 | Human | Colorectum | SER | 3.42e-04 | 4.27e-01 | -0.1526 |
| 54492 | NEURL1B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.62e-09 | 4.70e-01 | -0.1464 |
| 54492 | NEURL1B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.14e-04 | 2.92e-01 | -0.1001 |
| 54492 | NEURL1B | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.73e-10 | 5.02e-01 | -0.059 |
| 54492 | NEURL1B | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.75e-13 | 9.63e-01 | -0.2061 |
| 54492 | NEURL1B | HTA11_866_3004761011 | Human | Colorectum | AD | 1.32e-03 | 2.88e-01 | 0.096 |
| 54492 | NEURL1B | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.61e-04 | 1.82e-01 | 0.0674 |
| 54492 | NEURL1B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.58e-03 | 3.02e-01 | 0.3859 |
| 54492 | NEURL1B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.35e-05 | 2.83e-01 | 0.3005 |
| 54492 | NEURL1B | A015-C-104 | Human | Colorectum | FAP | 4.07e-04 | -1.25e-01 | -0.1899 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
| GO:0007219 | Colorectum | AD | Notch signaling pathway | 50/3918 | 172/18723 | 6.92e-03 | 4.26e-02 | 50 |
| GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
| GO:00725942 | Colorectum | MSS | establishment of protein localization to organelle | 139/3467 | 422/18723 | 5.75e-13 | 1.12e-10 | 139 |
| GO:00725944 | Colorectum | FAP | establishment of protein localization to organelle | 96/2622 | 422/18723 | 6.63e-07 | 3.20e-05 | 96 |
| GO:00072191 | Colorectum | FAP | Notch signaling pathway | 38/2622 | 172/18723 | 2.56e-03 | 2.01e-02 | 38 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NEURL1B | SNV | Missense_Mutation | novel | c.1484C>T | p.Pro495Leu | p.P495L | A8MQ27 | protein_coding | tolerated(0.32) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| NEURL1B | SNV | Missense_Mutation | rs532298637 | c.1360G>A | p.Asp454Asn | p.D454N | A8MQ27 | protein_coding | tolerated(0.16) | benign(0.167) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NEURL1B | SNV | Missense_Mutation | novel | c.472N>A | p.Val158Met | p.V158M | A8MQ27 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| NEURL1B | SNV | Missense_Mutation | rs565862357 | c.1543A>G | p.Ile515Val | p.I515V | A8MQ27 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| NEURL1B | SNV | Missense_Mutation | rs532298637 | c.1360N>A | p.Asp454Asn | p.D454N | A8MQ27 | protein_coding | tolerated(0.16) | benign(0.167) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NEURL1B | SNV | Missense_Mutation | novel | c.1580G>A | p.Cys527Tyr | p.C527Y | A8MQ27 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| NEURL1B | SNV | Missense_Mutation | c.404N>T | p.Glu135Val | p.E135V | A8MQ27 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-CC-A7IH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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