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Gene: NEPRO |
Gene summary for NEPRO |
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Gene information | Species | Human | Gene symbol | NEPRO | Gene ID | 25871 |
Gene name | nucleolus and neural progenitor protein | |
Gene Alias | ANXD3 | |
Cytomap | 3q13.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q6NW34 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25871 | NEPRO | LZE4T | Human | Esophagus | ESCC | 1.61e-25 | 5.19e-01 | 0.0811 |
25871 | NEPRO | LZE5T | Human | Esophagus | ESCC | 4.91e-03 | 7.47e-02 | 0.0514 |
25871 | NEPRO | LZE7T | Human | Esophagus | ESCC | 3.31e-09 | 5.77e-01 | 0.0667 |
25871 | NEPRO | LZE8T | Human | Esophagus | ESCC | 9.42e-05 | 9.63e-02 | 0.067 |
25871 | NEPRO | LZE22T | Human | Esophagus | ESCC | 1.85e-05 | 2.67e-01 | 0.068 |
25871 | NEPRO | LZE24T | Human | Esophagus | ESCC | 2.38e-20 | 5.65e-01 | 0.0596 |
25871 | NEPRO | LZE6T | Human | Esophagus | ESCC | 9.14e-07 | 2.76e-01 | 0.0845 |
25871 | NEPRO | HCC2 | Human | Liver | HCC | 2.06e-10 | 2.73e+00 | 0.5341 |
25871 | NEPRO | S014 | Human | Liver | HCC | 1.01e-14 | 4.47e-01 | 0.2254 |
25871 | NEPRO | S015 | Human | Liver | HCC | 4.11e-21 | 6.79e-01 | 0.2375 |
25871 | NEPRO | S016 | Human | Liver | HCC | 1.41e-20 | 5.03e-01 | 0.2243 |
25871 | NEPRO | S027 | Human | Liver | HCC | 2.11e-03 | 3.89e-01 | 0.2446 |
25871 | NEPRO | S028 | Human | Liver | HCC | 1.43e-07 | 3.66e-01 | 0.2503 |
25871 | NEPRO | S029 | Human | Liver | HCC | 7.44e-12 | 4.66e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:00085935 | Esophagus | ESCC | regulation of Notch signaling pathway | 59/8552 | 95/18723 | 9.12e-04 | 4.65e-03 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NEPRO | SNV | Missense_Mutation | c.1241N>T | p.Pro414Leu | p.P414L | Q6NW34 | protein_coding | deleterious(0.01) | possibly_damaging(0.864) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEPRO | SNV | Missense_Mutation | rs745896285 | c.1576N>C | p.Asn526His | p.N526H | Q6NW34 | protein_coding | tolerated(0.12) | benign(0.323) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NEPRO | SNV | Missense_Mutation | rs372396645 | c.7N>A | p.Ala3Thr | p.A3T | Q6NW34 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-A6-6649-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
NEPRO | SNV | Missense_Mutation | novel | c.1623N>A | p.Met541Ile | p.M541I | Q6NW34 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NEPRO | SNV | Missense_Mutation | c.46N>G | p.Arg16Gly | p.R16G | Q6NW34 | protein_coding | deleterious(0.04) | benign(0.286) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
NEPRO | SNV | Missense_Mutation | c.1540N>T | p.Pro514Ser | p.P514S | Q6NW34 | protein_coding | tolerated(0.22) | benign(0.045) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NEPRO | SNV | Missense_Mutation | c.277N>C | p.Lys93Gln | p.K93Q | Q6NW34 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEPRO | SNV | Missense_Mutation | novel | c.221N>C | p.Asn74Thr | p.N74T | Q6NW34 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NEPRO | SNV | Missense_Mutation | novel | c.343G>A | p.Glu115Lys | p.E115K | Q6NW34 | protein_coding | tolerated(0.66) | benign(0.009) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NEPRO | SNV | Missense_Mutation | novel | c.1667N>G | p.Asp556Gly | p.D556G | Q6NW34 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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