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Gene: NELL2 |
Gene summary for NELL2 |
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Gene information | Species | Human | Gene symbol | NELL2 | Gene ID | 4753 |
Gene name | neural EGFL like 2 | |
Gene Alias | NRP2 | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | B7Z625 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4753 | NELL2 | LZE7T | Human | Esophagus | ESCC | 4.10e-06 | 4.89e-01 | 0.0667 |
4753 | NELL2 | LZE24T | Human | Esophagus | ESCC | 9.40e-14 | 4.22e-01 | 0.0596 |
4753 | NELL2 | P4T-E | Human | Esophagus | ESCC | 3.02e-19 | 6.08e-01 | 0.1323 |
4753 | NELL2 | P5T-E | Human | Esophagus | ESCC | 3.10e-10 | 2.83e-01 | 0.1327 |
4753 | NELL2 | P8T-E | Human | Esophagus | ESCC | 1.18e-20 | 5.94e-01 | 0.0889 |
4753 | NELL2 | P10T-E | Human | Esophagus | ESCC | 2.53e-02 | 9.09e-02 | 0.116 |
4753 | NELL2 | P12T-E | Human | Esophagus | ESCC | 3.40e-04 | 1.71e-01 | 0.1122 |
4753 | NELL2 | P16T-E | Human | Esophagus | ESCC | 1.22e-02 | 9.64e-02 | 0.1153 |
4753 | NELL2 | P20T-E | Human | Esophagus | ESCC | 1.68e-33 | 7.19e-01 | 0.1124 |
4753 | NELL2 | P22T-E | Human | Esophagus | ESCC | 4.20e-16 | 3.33e-01 | 0.1236 |
4753 | NELL2 | P26T-E | Human | Esophagus | ESCC | 2.03e-04 | 2.27e-01 | 0.1276 |
4753 | NELL2 | P27T-E | Human | Esophagus | ESCC | 1.56e-11 | 3.56e-01 | 0.1055 |
4753 | NELL2 | P32T-E | Human | Esophagus | ESCC | 3.36e-10 | 3.01e-01 | 0.1666 |
4753 | NELL2 | P37T-E | Human | Esophagus | ESCC | 1.52e-02 | 4.21e-01 | 0.1371 |
4753 | NELL2 | P39T-E | Human | Esophagus | ESCC | 5.84e-15 | 3.64e-01 | 0.0894 |
4753 | NELL2 | P47T-E | Human | Esophagus | ESCC | 6.42e-09 | 2.49e-01 | 0.1067 |
4753 | NELL2 | P49T-E | Human | Esophagus | ESCC | 1.71e-19 | 2.30e+00 | 0.1768 |
4753 | NELL2 | P52T-E | Human | Esophagus | ESCC | 1.55e-11 | 3.66e-01 | 0.1555 |
4753 | NELL2 | P54T-E | Human | Esophagus | ESCC | 2.78e-14 | 4.11e-01 | 0.0975 |
4753 | NELL2 | P56T-E | Human | Esophagus | ESCC | 4.32e-02 | 2.73e-01 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NELL2 | SNV | Missense_Mutation | c.1252N>T | p.Leu418Phe | p.L418F | Q99435 | protein_coding | tolerated(0.71) | benign(0.003) | TCGA-AN-A0FZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NELL2 | SNV | Missense_Mutation | c.1819N>A | p.Asp607Asn | p.D607N | Q99435 | protein_coding | deleterious(0.05) | probably_damaging(0.983) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NELL2 | SNV | Missense_Mutation | c.2338N>C | p.Asp780His | p.D780H | Q99435 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
NELL2 | insertion | Nonsense_Mutation | novel | c.2374_2375insGTAAACTCCATTAAATTTA | p.Glu792GlyfsTer5 | p.E792Gfs*5 | Q99435 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
NELL2 | deletion | Frame_Shift_Del | c.1390delN | p.Arg464GlufsTer3 | p.R464Efs*3 | Q99435 | protein_coding | TCGA-AR-A0TR-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
NELL2 | SNV | Missense_Mutation | novel | c.1724G>A | p.Cys575Tyr | p.C575Y | Q99435 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-DG-A2KJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
NELL2 | SNV | Missense_Mutation | c.1810A>T | p.Thr604Ser | p.T604S | Q99435 | protein_coding | tolerated(0.24) | benign(0.022) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NELL2 | SNV | Missense_Mutation | c.1297N>T | p.His433Tyr | p.H433Y | Q99435 | protein_coding | tolerated(0.11) | benign(0.105) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NELL2 | SNV | Missense_Mutation | c.706N>T | p.Gly236Cys | p.G236C | Q99435 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NELL2 | SNV | Missense_Mutation | novel | c.522N>C | p.Glu174Asp | p.E174D | Q99435 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AA-3862-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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