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Gene: NECAP2 |
Gene summary for NECAP2 |
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Gene information | Species | Human | Gene symbol | NECAP2 | Gene ID | 55707 |
Gene name | NECAP endocytosis associated 2 | |
Gene Alias | NECAP2 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NVZ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55707 | NECAP2 | LZE4T | Human | Esophagus | ESCC | 1.69e-04 | 2.55e-01 | 0.0811 |
55707 | NECAP2 | LZE7T | Human | Esophagus | ESCC | 4.16e-03 | 3.72e-01 | 0.0667 |
55707 | NECAP2 | LZE8T | Human | Esophagus | ESCC | 3.44e-12 | 2.52e-01 | 0.067 |
55707 | NECAP2 | LZE20T | Human | Esophagus | ESCC | 3.21e-09 | 3.83e-01 | 0.0662 |
55707 | NECAP2 | LZE22D1 | Human | Esophagus | HGIN | 6.61e-04 | 1.22e-01 | 0.0595 |
55707 | NECAP2 | LZE24T | Human | Esophagus | ESCC | 3.73e-20 | 4.69e-01 | 0.0596 |
55707 | NECAP2 | LZE6T | Human | Esophagus | ESCC | 2.48e-03 | 1.77e-01 | 0.0845 |
55707 | NECAP2 | P1T-E | Human | Esophagus | ESCC | 6.13e-06 | 3.45e-01 | 0.0875 |
55707 | NECAP2 | P2T-E | Human | Esophagus | ESCC | 4.75e-34 | 5.43e-01 | 0.1177 |
55707 | NECAP2 | P4T-E | Human | Esophagus | ESCC | 1.19e-25 | 6.38e-01 | 0.1323 |
55707 | NECAP2 | P5T-E | Human | Esophagus | ESCC | 2.38e-14 | 3.89e-01 | 0.1327 |
55707 | NECAP2 | P8T-E | Human | Esophagus | ESCC | 9.45e-20 | 3.60e-01 | 0.0889 |
55707 | NECAP2 | P9T-E | Human | Esophagus | ESCC | 5.42e-12 | 1.74e-01 | 0.1131 |
55707 | NECAP2 | P10T-E | Human | Esophagus | ESCC | 1.02e-25 | 5.18e-01 | 0.116 |
55707 | NECAP2 | P11T-E | Human | Esophagus | ESCC | 8.27e-15 | 6.73e-01 | 0.1426 |
55707 | NECAP2 | P12T-E | Human | Esophagus | ESCC | 2.08e-23 | 5.48e-01 | 0.1122 |
55707 | NECAP2 | P15T-E | Human | Esophagus | ESCC | 1.07e-23 | 5.16e-01 | 0.1149 |
55707 | NECAP2 | P16T-E | Human | Esophagus | ESCC | 1.49e-18 | 5.05e-01 | 0.1153 |
55707 | NECAP2 | P17T-E | Human | Esophagus | ESCC | 4.49e-05 | 4.51e-01 | 0.1278 |
55707 | NECAP2 | P19T-E | Human | Esophagus | ESCC | 2.55e-05 | 7.01e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NECAP2 | SNV | Missense_Mutation | c.302N>A | p.Arg101Gln | p.R101Q | Q9NVZ3 | protein_coding | tolerated(0.09) | benign(0.167) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NECAP2 | SNV | Missense_Mutation | rs747971763 | c.787N>A | p.Glu263Lys | p.E263K | Q9NVZ3 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
NECAP2 | SNV | Missense_Mutation | rs778687400 | c.274G>A | p.Val92Met | p.V92M | Q9NVZ3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NECAP2 | SNV | Missense_Mutation | c.770N>A | p.Gly257Asp | p.G257D | Q9NVZ3 | protein_coding | deleterious_low_confidence(0.01) | benign(0.011) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
NECAP2 | SNV | Missense_Mutation | rs778687400 | c.274G>A | p.Val92Met | p.V92M | Q9NVZ3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NECAP2 | SNV | Missense_Mutation | novel | c.635N>T | p.Ser212Phe | p.S212F | Q9NVZ3 | protein_coding | tolerated(0.29) | benign(0.286) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
NECAP2 | SNV | Missense_Mutation | rs774560000 | c.583N>G | p.Lys195Glu | p.K195E | Q9NVZ3 | protein_coding | deleterious(0.02) | possibly_damaging(0.544) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NECAP2 | SNV | Missense_Mutation | c.286G>A | p.Glu96Lys | p.E96K | Q9NVZ3 | protein_coding | tolerated(0.15) | benign(0.041) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NECAP2 | SNV | Missense_Mutation | c.514N>T | p.Ala172Ser | p.A172S | Q9NVZ3 | protein_coding | tolerated(0.41) | benign(0.022) | TCGA-F5-6702-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | PD | |
NECAP2 | SNV | Missense_Mutation | c.286G>A | p.Glu96Lys | p.E96K | Q9NVZ3 | protein_coding | tolerated(0.15) | benign(0.041) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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