Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: NDUFA7

Gene summary for NDUFA7

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

NDUFA7

Gene ID

4701

Gene nameNADH:ubiquinone oxidoreductase subunit A7
Gene AliasB14.5a
Cytomap19p13.2
Gene Typeprotein-coding
GO ID

GO:0006091

UniProtAcc

O95182


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4701NDUFA7LZE2THumanEsophagusESCC6.27e-097.87e-010.082
4701NDUFA7LZE3DHumanEsophagusHGIN1.08e-028.95e-010.0668
4701NDUFA7LZE4THumanEsophagusESCC7.41e-207.00e-010.0811
4701NDUFA7LZE5THumanEsophagusESCC7.80e-121.24e+000.0514
4701NDUFA7LZE7THumanEsophagusESCC2.75e-342.31e+000.0667
4701NDUFA7LZE8THumanEsophagusESCC1.01e-299.11e-010.067
4701NDUFA7LZE20THumanEsophagusESCC7.47e-318.99e-010.0662
4701NDUFA7LZE22D1HumanEsophagusHGIN6.17e-186.72e-010.0595
4701NDUFA7LZE22THumanEsophagusESCC1.29e-088.06e-010.068
4701NDUFA7LZE24D1HumanEsophagusHGIN1.15e-028.95e-010.054
4701NDUFA7LZE24THumanEsophagusESCC1.65e-461.22e+000.0596
4701NDUFA7LZE21THumanEsophagusESCC3.30e-211.31e+000.0655
4701NDUFA7LZE6THumanEsophagusESCC4.09e-219.23e-010.0845
4701NDUFA7P1T-EHumanEsophagusESCC1.77e-186.53e-010.0875
4701NDUFA7P2T-EHumanEsophagusESCC2.04e-183.28e-010.1177
4701NDUFA7P4T-EHumanEsophagusESCC8.63e-265.19e-010.1323
4701NDUFA7P5T-EHumanEsophagusESCC2.72e-367.03e-010.1327
4701NDUFA7P8T-EHumanEsophagusESCC1.39e-254.74e-010.0889
4701NDUFA7P9T-EHumanEsophagusESCC1.46e-346.76e-010.1131
4701NDUFA7P10T-EHumanEsophagusESCC5.43e-436.29e-010.116
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000611920EsophagusHGINoxidative phosphorylation69/2587141/187231.37e-232.05e-2069
GO:000906020EsophagusHGINaerobic respiration81/2587189/187231.07e-229.26e-2081
GO:004603427EsophagusHGINATP metabolic process101/2587277/187231.53e-211.02e-18101
GO:000609120EsophagusHGINgeneration of precursor metabolites and energy145/2587490/187233.41e-202.04e-17145
GO:004533320EsophagusHGINcellular respiration86/2587230/187232.41e-191.20e-1686
GO:001598020EsophagusHGINenergy derivation by oxidation of organic compounds105/2587318/187231.16e-184.99e-16105
GO:004277320EsophagusHGINATP synthesis coupled electron transport49/258795/187232.21e-187.36e-1649
GO:004277520EsophagusHGINmitochondrial ATP synthesis coupled electron transport49/258795/187232.21e-187.36e-1649
GO:002290420EsophagusHGINrespiratory electron transport chain51/2587114/187239.63e-162.41e-1351
GO:001964620EsophagusHGINaerobic electron transport chain43/258787/187231.98e-154.41e-1343
GO:002290020EsophagusHGINelectron transport chain66/2587175/187232.21e-154.73e-1366
GO:000612020EsophagusHGINmitochondrial electron transport, NADH to ubiquinone28/258751/187235.72e-127.30e-1028
GO:00325435EsophagusHGINmitochondrial translation23/258776/187231.61e-043.16e-0323
GO:01400534EsophagusHGINmitochondrial gene expression27/2587108/187231.34e-031.57e-0227
GO:0006091110EsophagusESCCgeneration of precursor metabolites and energy331/8552490/187233.86e-238.45e-21331
GO:0045333110EsophagusESCCcellular respiration173/8552230/187234.53e-205.99e-18173
GO:014005313EsophagusESCCmitochondrial gene expression93/8552108/187231.96e-182.03e-1693
GO:0009060110EsophagusESCCaerobic respiration145/8552189/187232.16e-182.21e-16145
GO:0015980110EsophagusESCCenergy derivation by oxidation of organic compounds220/8552318/187231.20e-171.09e-15220
GO:0022900110EsophagusESCCelectron transport chain133/8552175/187232.18e-161.67e-14133
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0501239EsophagusHGINParkinson disease124/1383266/84655.95e-329.70e-307.70e-30124
hsa0501630EsophagusHGINHuntington disease129/1383306/84656.81e-287.41e-265.88e-26129
hsa0502030EsophagusHGINPrion disease117/1383273/84654.15e-263.38e-242.69e-24117
hsa0501430EsophagusHGINAmyotrophic lateral sclerosis140/1383364/84652.13e-251.16e-239.19e-24140
hsa0019030EsophagusHGINOxidative phosphorylation68/1383134/84651.73e-208.07e-196.41e-1968
hsa0520839EsophagusHGINChemical carcinogenesis - reactive oxygen species92/1383223/84652.41e-199.83e-187.80e-1892
hsa0502230EsophagusHGINPathways of neurodegeneration - multiple diseases153/1383476/84651.22e-184.41e-173.50e-17153
hsa0501030EsophagusHGINAlzheimer disease130/1383384/84655.26e-181.71e-161.36e-16130
hsa0471439EsophagusHGINThermogenesis91/1383232/84651.97e-175.36e-164.25e-1691
hsa0541530EsophagusHGINDiabetic cardiomyopathy80/1383203/84651.35e-153.38e-142.69e-1480
hsa0493230EsophagusHGINNon-alcoholic fatty liver disease66/1383155/84655.21e-151.21e-139.64e-1466
hsa0472327EsophagusHGINRetrograde endocannabinoid signaling36/1383148/84657.52e-034.63e-023.68e-0236
hsa05012114EsophagusHGINParkinson disease124/1383266/84655.95e-329.70e-307.70e-30124
hsa05016113EsophagusHGINHuntington disease129/1383306/84656.81e-287.41e-265.88e-26129
hsa05020113EsophagusHGINPrion disease117/1383273/84654.15e-263.38e-242.69e-24117
hsa05014113EsophagusHGINAmyotrophic lateral sclerosis140/1383364/84652.13e-251.16e-239.19e-24140
hsa00190113EsophagusHGINOxidative phosphorylation68/1383134/84651.73e-208.07e-196.41e-1968
hsa05208115EsophagusHGINChemical carcinogenesis - reactive oxygen species92/1383223/84652.41e-199.83e-187.80e-1892
hsa05022113EsophagusHGINPathways of neurodegeneration - multiple diseases153/1383476/84651.22e-184.41e-173.50e-17153
hsa05010113EsophagusHGINAlzheimer disease130/1383384/84655.26e-181.71e-161.36e-16130
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
NDUFA7SNVMissense_Mutationnovelc.227N>Cp.Leu76Prop.L76PO95182protein_codingdeleterious(0)probably_damaging(0.997)TCGA-A2-A3Y0-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
NDUFA7insertionFrame_Shift_Insnovelc.147_148insGTGACCCACCGTGCCTGGCCTGp.Ser50ValfsTer49p.S50Vfs*49O95182protein_codingTCGA-AP-A0LH-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapypaclitaxelPD
NDUFA7SNVMissense_Mutationnovelc.14C>Tp.Thr5Ilep.T5IO95182protein_codingdeleterious(0)probably_damaging(0.996)TCGA-G3-AAV3-01Liverliver hepatocellular carcinomaFemale<65I/IIUnknownUnknownSD
NDUFA7SNVMissense_Mutationc.125N>Gp.Pro42Argp.P42RO95182protein_codingdeleterious(0)probably_damaging(0.99)TCGA-99-8025-01Lunglung adenocarcinomaFemale>=65III/IVChemotherapygemzarSD
NDUFA7SNVMissense_Mutationnovelc.249N>Cp.Glu83Aspp.E83DO95182protein_codingtolerated(0.27)benign(0.005)TCGA-CV-5970-01Oral cavityhead & neck squamous cell carcinomaMale<65I/IIUnknownUnknownPD
NDUFA7SNVMissense_Mutationnovelc.206T>Cp.Ile69Thrp.I69TO95182protein_codingdeleterious(0)benign(0.129)TCGA-XK-AAIW-01Prostateprostate adenocarcinomaMale>=659UnknownUnknownPD
NDUFA7SNVMissense_Mutationnovelc.238N>Cp.Lys80Glnp.K80QO95182protein_codingtolerated(0.27)benign(0.037)TCGA-EL-A3ZO-01Thyroidthyroid carcinomaFemale>=65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
4701NDUFA7ENZYMEinhibitorCHEMBL3545320ME-344
4701NDUFA7ENZYMEinhibitorCHEMBL1703METFORMIN HYDROCHLORIDE
4701NDUFA7ENZYMEinhibitorCHEMBL3545135NV-128
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