Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: NDUFA5

Gene summary for NDUFA5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

NDUFA5

Gene ID

4698

Gene nameNADH:ubiquinone oxidoreductase subunit A5
Gene AliasB13
Cytomap7q31.32
Gene Typeprotein-coding
GO ID

GO:0006091

UniProtAcc

A0A087X1G1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4698NDUFA5HTA11_78_2000001011HumanColorectumAD1.41e-033.73e-01-0.1088
4698NDUFA5HTA11_347_2000001011HumanColorectumAD1.66e-074.31e-01-0.1954
4698NDUFA5HTA11_99999970781_79442HumanColorectumMSS1.77e-022.97e-010.294
4698NDUFA5A015-C-203HumanColorectumFAP1.59e-07-2.10e-01-0.1294
4698NDUFA5A002-C-201HumanColorectumFAP1.24e-02-1.46e-010.0324
4698NDUFA5A001-C-119HumanColorectumFAP8.39e-03-2.14e-01-0.1557
4698NDUFA5A001-C-108HumanColorectumFAP5.11e-04-1.64e-01-0.0272
4698NDUFA5A002-C-205HumanColorectumFAP8.23e-07-2.25e-01-0.1236
4698NDUFA5A001-C-104HumanColorectumFAP1.65e-03-1.70e-010.0184
4698NDUFA5A015-C-006HumanColorectumFAP1.97e-03-2.18e-01-0.0994
4698NDUFA5A015-C-106HumanColorectumFAP6.30e-06-1.62e-01-0.0511
4698NDUFA5A002-C-114HumanColorectumFAP4.36e-03-1.75e-01-0.1561
4698NDUFA5A015-C-104HumanColorectumFAP1.26e-06-1.65e-01-0.1899
4698NDUFA5A001-C-014HumanColorectumFAP1.87e-04-1.74e-010.0135
4698NDUFA5A002-C-016HumanColorectumFAP1.34e-03-1.76e-010.0521
4698NDUFA5A015-C-002HumanColorectumFAP4.57e-04-2.40e-01-0.0763
4698NDUFA5A001-C-203HumanColorectumFAP1.42e-03-1.40e-01-0.0481
4698NDUFA5A002-C-116HumanColorectumFAP1.15e-08-1.66e-01-0.0452
4698NDUFA5A014-C-008HumanColorectumFAP8.01e-03-2.19e-01-0.191
4698NDUFA5A018-E-020HumanColorectumFAP6.73e-05-2.08e-01-0.2034
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0046034ColorectumADATP metabolic process142/3918277/187232.64e-298.26e-26142
GO:0006091ColorectumADgeneration of precursor metabolites and energy209/3918490/187233.17e-286.61e-25209
GO:0009060ColorectumADaerobic respiration108/3918189/187239.14e-281.43e-24108
GO:0045333ColorectumADcellular respiration119/3918230/187233.21e-254.02e-22119
GO:0006119ColorectumADoxidative phosphorylation83/3918141/187237.95e-238.30e-2083
GO:0015980ColorectumADenergy derivation by oxidation of organic compounds143/3918318/187232.78e-222.49e-19143
GO:0022900ColorectumADelectron transport chain89/3918175/187231.42e-188.91e-1689
GO:0019646ColorectumADaerobic electron transport chain53/391887/187235.58e-162.16e-1353
GO:0042773ColorectumADATP synthesis coupled electron transport56/391895/187236.76e-162.22e-1356
GO:0042775ColorectumADmitochondrial ATP synthesis coupled electron transport56/391895/187236.76e-162.22e-1356
GO:0022904ColorectumADrespiratory electron transport chain63/3918114/187238.23e-162.45e-1363
GO:0006120ColorectumADmitochondrial electron transport, NADH to ubiquinone32/391851/187231.12e-101.11e-0832
GO:0010257ColorectumADNADH dehydrogenase complex assembly34/391857/187232.15e-101.89e-0834
GO:0032981ColorectumADmitochondrial respiratory chain complex I assembly34/391857/187232.15e-101.89e-0834
GO:0033108ColorectumADmitochondrial respiratory chain complex assembly46/391893/187238.95e-106.91e-0846
GO:00090602ColorectumMSSaerobic respiration98/3467189/187233.35e-251.05e-2198
GO:00060912ColorectumMSSgeneration of precursor metabolites and energy186/3467490/187231.14e-242.15e-21186
GO:00460342ColorectumMSSATP metabolic process125/3467277/187231.38e-242.15e-21125
GO:00453332ColorectumMSScellular respiration107/3467230/187231.64e-222.05e-19107
GO:00159802ColorectumMSSenergy derivation by oxidation of organic compounds131/3467318/187232.60e-212.70e-18131
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05012ColorectumADParkinson disease147/2092266/84652.53e-278.48e-255.41e-25147
hsa05208ColorectumADChemical carcinogenesis - reactive oxygen species126/2092223/84651.01e-241.68e-221.07e-22126
hsa00190ColorectumADOxidative phosphorylation86/2092134/84652.47e-222.76e-201.76e-2086
hsa05415ColorectumADDiabetic cardiomyopathy114/2092203/84653.65e-223.06e-201.95e-20114
hsa05010ColorectumADAlzheimer disease174/2092384/84651.82e-199.26e-185.91e-18174
hsa05016ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa04714ColorectumADThermogenesis120/2092232/84652.76e-191.16e-177.37e-18120
hsa04932ColorectumADNon-alcoholic fatty liver disease90/2092155/84654.83e-191.80e-171.15e-1790
hsa05020ColorectumADPrion disease133/2092273/84652.47e-188.29e-175.29e-17133
hsa05014ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa05022ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa04723ColorectumADRetrograde endocannabinoid signaling59/2092148/84652.94e-052.73e-041.74e-0459
hsa050121ColorectumADParkinson disease147/2092266/84652.53e-278.48e-255.41e-25147
hsa052081ColorectumADChemical carcinogenesis - reactive oxygen species126/2092223/84651.01e-241.68e-221.07e-22126
hsa001901ColorectumADOxidative phosphorylation86/2092134/84652.47e-222.76e-201.76e-2086
hsa054151ColorectumADDiabetic cardiomyopathy114/2092203/84653.65e-223.06e-201.95e-20114
hsa050101ColorectumADAlzheimer disease174/2092384/84651.82e-199.26e-185.91e-18174
hsa050161ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa047141ColorectumADThermogenesis120/2092232/84652.76e-191.16e-177.37e-18120
hsa049321ColorectumADNon-alcoholic fatty liver disease90/2092155/84654.83e-191.80e-171.15e-1790
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
NDUFA5SNVMissense_Mutationc.314A>Gp.Glu105Glyp.E105GQ16718protein_codingtolerated(0.1)benign(0.127)TCGA-A8-A07W-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyexemestaneSD
NDUFA5deletionFrame_Shift_Delc.122delNp.Asn41MetfsTer28p.N41Mfs*28Q16718protein_codingTCGA-CK-5916-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
NDUFA5SNVMissense_Mutationnovelc.320C>Tp.Pro107Leup.P107LQ16718protein_codingdeleterious(0.04)benign(0.111)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
NDUFA5SNVMissense_Mutationnovelc.320N>Tp.Pro107Leup.P107LQ16718protein_codingdeleterious(0.04)benign(0.111)TCGA-A5-A0GG-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
NDUFA5SNVMissense_Mutationnovelc.134N>Tp.Arg45Ilep.R45IQ16718protein_codingdeleterious(0)probably_damaging(0.995)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
NDUFA5SNVMissense_Mutationnovelc.212N>Gp.Gln71Argp.Q71RQ16718protein_codingtolerated(0.16)benign(0.003)TCGA-B5-A3FA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
NDUFA5SNVMissense_Mutationnovelc.90N>Tp.Lys30Asnp.K30NQ16718protein_codingdeleterious(0.02)benign(0.208)TCGA-D1-A16X-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
NDUFA5SNVMissense_Mutationc.28N>Tp.Gly10Cysp.G10CQ16718protein_codingdeleterious(0)probably_damaging(0.98)TCGA-CC-A3MC-01Liverliver hepatocellular carcinomaMale<65III/IVUnknownUnknownPD
NDUFA5SNVMissense_Mutationnovelc.149A>Tp.Gln50Leup.Q50LQ16718protein_codingdeleterious(0.04)possibly_damaging(0.735)TCGA-DD-AACL-01Liverliver hepatocellular carcinomaFemale>=65I/IIUnknownUnknownSD
NDUFA5SNVMissense_Mutationnovelc.282G>Ap.Met94Ilep.M94IQ16718protein_codingtolerated(0.1)benign(0.14)TCGA-78-7156-01Lunglung adenocarcinomaMale<65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
4698NDUFA5ENZYMEinhibitorCHEMBL3545320ME-344
4698NDUFA5ENZYMEinhibitorCHEMBL1703METFORMIN HYDROCHLORIDE
4698NDUFA5ENZYMEinhibitorCHEMBL3545135NV-128
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