![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NDST3 |
Gene summary for NDST3 |
![]() |
Gene information | Species | Human | Gene symbol | NDST3 | Gene ID | 9348 |
Gene name | N-deacetylase and N-sulfotransferase 3 | |
Gene Alias | HSST3 | |
Cytomap | 4q26 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | O95803 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9348 | NDST3 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.76e-04 | 3.30e-01 | -0.1088 |
9348 | NDST3 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.81e-10 | 3.80e-01 | -0.1954 |
9348 | NDST3 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.84e-09 | 3.69e-01 | -0.1464 |
9348 | NDST3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.80e-03 | 1.66e-01 | -0.1001 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDST3 | SNV | Missense_Mutation | c.542C>T | p.Pro181Leu | p.P181L | O95803 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
NDST3 | SNV | Missense_Mutation | rs775885552 | c.949N>C | p.Glu317Gln | p.E317Q | O95803 | protein_coding | tolerated(0.11) | possibly_damaging(0.861) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NDST3 | SNV | Missense_Mutation | novel | c.1894N>C | p.Glu632Gln | p.E632Q | O95803 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDST3 | SNV | Missense_Mutation | novel | c.1177N>A | p.Glu393Lys | p.E393K | O95803 | protein_coding | tolerated(0.68) | benign(0.309) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
NDST3 | SNV | Missense_Mutation | c.519G>C | p.Gln173His | p.Q173H | O95803 | protein_coding | tolerated(0.46) | benign(0.043) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NDST3 | SNV | Missense_Mutation | rs747142440 | c.2126N>A | p.Arg709Gln | p.R709Q | O95803 | protein_coding | deleterious(0.04) | possibly_damaging(0.802) | TCGA-LL-A7SZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
NDST3 | insertion | Nonsense_Mutation | novel | c.1473_1474insCCTAGAGTATGATAGATTGTCCA | p.Gly492ProfsTer4 | p.G492Pfs*4 | O95803 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NDST3 | insertion | Nonsense_Mutation | novel | c.914_915insCAAGTGA | p.Leu306LysfsTer2 | p.L306Kfs*2 | O95803 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
NDST3 | SNV | Missense_Mutation | c.620C>A | p.Ser207Tyr | p.S207Y | O95803 | protein_coding | deleterious(0.01) | possibly_damaging(0.793) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NDST3 | SNV | Missense_Mutation | c.2137G>C | p.Asp713His | p.D713H | O95803 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |