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Gene: NDEL1 |
Gene summary for NDEL1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NDEL1 | Gene ID | 81565 |
| Gene name | nudE neurodevelopment protein 1 like 1 | |
| Gene Alias | EOPA | |
| Cytomap | 17p13.1 | |
| Gene Type | protein-coding | GO ID | GO:0000132 | UniProtAcc | Q9GZM8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 81565 | NDEL1 | LZE4T | Human | Esophagus | ESCC | 7.51e-19 | 2.80e-01 | 0.0811 |
| 81565 | NDEL1 | LZE5T | Human | Esophagus | ESCC | 1.56e-04 | 3.79e-02 | 0.0514 |
| 81565 | NDEL1 | LZE7T | Human | Esophagus | ESCC | 1.56e-04 | 1.41e-01 | 0.0667 |
| 81565 | NDEL1 | LZE8T | Human | Esophagus | ESCC | 1.57e-06 | -4.17e-02 | 0.067 |
| 81565 | NDEL1 | LZE20T | Human | Esophagus | ESCC | 2.53e-05 | 8.31e-03 | 0.0662 |
| 81565 | NDEL1 | LZE24T | Human | Esophagus | ESCC | 4.06e-16 | 5.50e-01 | 0.0596 |
| 81565 | NDEL1 | LZE21T | Human | Esophagus | ESCC | 2.99e-03 | 2.07e-01 | 0.0655 |
| 81565 | NDEL1 | LZE6T | Human | Esophagus | ESCC | 3.79e-05 | 5.39e-02 | 0.0845 |
| 81565 | NDEL1 | P1T-E | Human | Esophagus | ESCC | 1.19e-06 | 4.41e-01 | 0.0875 |
| 81565 | NDEL1 | P2T-E | Human | Esophagus | ESCC | 3.61e-24 | 1.71e-01 | 0.1177 |
| 81565 | NDEL1 | P4T-E | Human | Esophagus | ESCC | 5.75e-24 | 3.82e-01 | 0.1323 |
| 81565 | NDEL1 | P5T-E | Human | Esophagus | ESCC | 1.81e-06 | -5.77e-02 | 0.1327 |
| 81565 | NDEL1 | P8T-E | Human | Esophagus | ESCC | 1.31e-21 | 2.43e-01 | 0.0889 |
| 81565 | NDEL1 | P9T-E | Human | Esophagus | ESCC | 2.34e-13 | 2.95e-01 | 0.1131 |
| 81565 | NDEL1 | P10T-E | Human | Esophagus | ESCC | 3.53e-25 | 2.23e-01 | 0.116 |
| 81565 | NDEL1 | P11T-E | Human | Esophagus | ESCC | 2.19e-12 | 4.84e-01 | 0.1426 |
| 81565 | NDEL1 | P12T-E | Human | Esophagus | ESCC | 2.04e-20 | 3.93e-01 | 0.1122 |
| 81565 | NDEL1 | P15T-E | Human | Esophagus | ESCC | 8.08e-15 | 1.19e-01 | 0.1149 |
| 81565 | NDEL1 | P16T-E | Human | Esophagus | ESCC | 1.01e-17 | 2.91e-01 | 0.1153 |
| 81565 | NDEL1 | P19T-E | Human | Esophagus | ESCC | 3.18e-08 | 4.06e-01 | 0.1662 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
| GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
| GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
| GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
| GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
| GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
| GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
| GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
| GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
| GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
| GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
| GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
| GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
| GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
| GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
| GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
| GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
| GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
| GO:001097013 | Esophagus | ESCC | transport along microtubule | 107/8552 | 155/18723 | 3.17e-09 | 6.80e-08 | 107 |
| GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NDEL1 | insertion | Frame_Shift_Ins | novel | c.997_998insG | p.Pro334SerfsTer16 | p.P334Sfs*16 | Q9GZM8 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| NDEL1 | insertion | In_Frame_Ins | novel | c.999_1000insGTGGCGTGTGCCTGCCTGCAGGCTCTTCTGGATAGCTTGAGC | p.Arg333_Pro334insValAlaCysAlaCysLeuGlnAlaLeuLeuAspSerLeuSer | p.R333_P334insVACACLQALLDSLS | Q9GZM8 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| NDEL1 | SNV | Missense_Mutation | c.145N>A | p.Ala49Thr | p.A49T | Q9GZM8 | protein_coding | tolerated(0.05) | benign(0.095) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
| NDEL1 | SNV | Missense_Mutation | c.601C>G | p.Leu201Val | p.L201V | Q9GZM8 | protein_coding | tolerated(0.51) | benign(0.06) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| NDEL1 | SNV | Missense_Mutation | rs200450931 | c.628G>A | p.Val210Ile | p.V210I | Q9GZM8 | protein_coding | tolerated(0.13) | benign(0.148) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| NDEL1 | SNV | Missense_Mutation | novel | c.973C>G | p.Pro325Ala | p.P325A | Q9GZM8 | protein_coding | tolerated(0.86) | benign(0) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| NDEL1 | SNV | Missense_Mutation | c.824A>T | p.Asn275Ile | p.N275I | Q9GZM8 | protein_coding | deleterious(0) | possibly_damaging(0.857) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| NDEL1 | SNV | Missense_Mutation | c.446G>A | p.Arg149Gln | p.R149Q | Q9GZM8 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| NDEL1 | SNV | Missense_Mutation | rs767052065 | c.848N>A | p.Arg283Gln | p.R283Q | Q9GZM8 | protein_coding | tolerated(0.07) | benign(0.366) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| NDEL1 | SNV | Missense_Mutation | novel | c.557N>T | p.Arg186Ile | p.R186I | Q9GZM8 | protein_coding | deleterious(0) | possibly_damaging(0.589) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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