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Gene: NDC1 |
Gene summary for NDC1 |
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Gene information | Species | Human | Gene symbol | NDC1 | Gene ID | 55706 |
Gene name | NDC1 transmembrane nucleoporin | |
Gene Alias | NET3 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9BTX1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55706 | NDC1 | CCI_1 | Human | Cervix | CC | 5.50e-04 | 3.25e-01 | 0.528 |
55706 | NDC1 | CCI_2 | Human | Cervix | CC | 4.14e-11 | 6.41e-01 | 0.5249 |
55706 | NDC1 | CCI_3 | Human | Cervix | CC | 3.47e-08 | 6.35e-01 | 0.516 |
55706 | NDC1 | LZE24T | Human | Esophagus | ESCC | 6.45e-06 | 3.22e-01 | 0.0596 |
55706 | NDC1 | P2T-E | Human | Esophagus | ESCC | 5.48e-15 | 2.64e-01 | 0.1177 |
55706 | NDC1 | P4T-E | Human | Esophagus | ESCC | 2.48e-05 | 2.65e-01 | 0.1323 |
55706 | NDC1 | P5T-E | Human | Esophagus | ESCC | 1.02e-12 | 3.17e-01 | 0.1327 |
55706 | NDC1 | P8T-E | Human | Esophagus | ESCC | 2.48e-09 | 1.17e-01 | 0.0889 |
55706 | NDC1 | P9T-E | Human | Esophagus | ESCC | 2.63e-02 | 1.25e-01 | 0.1131 |
55706 | NDC1 | P10T-E | Human | Esophagus | ESCC | 5.05e-17 | 2.97e-01 | 0.116 |
55706 | NDC1 | P12T-E | Human | Esophagus | ESCC | 2.57e-09 | 1.47e-01 | 0.1122 |
55706 | NDC1 | P15T-E | Human | Esophagus | ESCC | 2.44e-05 | 2.75e-01 | 0.1149 |
55706 | NDC1 | P16T-E | Human | Esophagus | ESCC | 6.26e-11 | 1.03e-01 | 0.1153 |
55706 | NDC1 | P19T-E | Human | Esophagus | ESCC | 2.61e-02 | 2.63e-01 | 0.1662 |
55706 | NDC1 | P20T-E | Human | Esophagus | ESCC | 6.17e-10 | 2.11e-01 | 0.1124 |
55706 | NDC1 | P21T-E | Human | Esophagus | ESCC | 3.70e-21 | 5.09e-01 | 0.1617 |
55706 | NDC1 | P22T-E | Human | Esophagus | ESCC | 7.79e-11 | 7.25e-02 | 0.1236 |
55706 | NDC1 | P23T-E | Human | Esophagus | ESCC | 1.02e-02 | 2.19e-01 | 0.108 |
55706 | NDC1 | P24T-E | Human | Esophagus | ESCC | 2.12e-05 | 1.53e-01 | 0.1287 |
55706 | NDC1 | P26T-E | Human | Esophagus | ESCC | 9.28e-14 | 2.02e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00988698 | Breast | Precancer | cellular oxidant detoxification | 20/1080 | 101/18723 | 1.07e-06 | 4.18e-05 | 20 |
GO:19907488 | Breast | Precancer | cellular detoxification | 21/1080 | 116/18723 | 2.67e-06 | 8.89e-05 | 21 |
GO:00987548 | Breast | Precancer | detoxification | 24/1080 | 152/18723 | 6.49e-06 | 1.81e-04 | 24 |
GO:00972378 | Breast | Precancer | cellular response to toxic substance | 21/1080 | 124/18723 | 7.98e-06 | 2.17e-04 | 21 |
GO:00096368 | Breast | Precancer | response to toxic substance | 31/1080 | 262/18723 | 1.18e-04 | 2.12e-03 | 31 |
GO:00713568 | Breast | Precancer | cellular response to tumor necrosis factor | 28/1080 | 229/18723 | 1.42e-04 | 2.45e-03 | 28 |
GO:00346128 | Breast | Precancer | response to tumor necrosis factor | 29/1080 | 253/18723 | 3.32e-04 | 4.70e-03 | 29 |
GO:000963613 | Breast | IDC | response to toxic substance | 44/1434 | 262/18723 | 6.33e-07 | 3.00e-05 | 44 |
GO:009875413 | Breast | IDC | detoxification | 29/1434 | 152/18723 | 3.97e-06 | 1.43e-04 | 29 |
GO:009886913 | Breast | IDC | cellular oxidant detoxification | 22/1434 | 101/18723 | 6.31e-06 | 1.98e-04 | 22 |
GO:199074813 | Breast | IDC | cellular detoxification | 23/1434 | 116/18723 | 2.02e-05 | 4.92e-04 | 23 |
GO:009723713 | Breast | IDC | cellular response to toxic substance | 24/1434 | 124/18723 | 2.05e-05 | 4.97e-04 | 24 |
GO:007135613 | Breast | IDC | cellular response to tumor necrosis factor | 35/1434 | 229/18723 | 6.64e-05 | 1.35e-03 | 35 |
GO:003461213 | Breast | IDC | response to tumor necrosis factor | 36/1434 | 253/18723 | 2.29e-04 | 3.64e-03 | 36 |
GO:000963623 | Breast | DCIS | response to toxic substance | 42/1390 | 262/18723 | 1.76e-06 | 6.56e-05 | 42 |
GO:009875423 | Breast | DCIS | detoxification | 29/1390 | 152/18723 | 2.15e-06 | 7.79e-05 | 29 |
GO:009886923 | Breast | DCIS | cellular oxidant detoxification | 22/1390 | 101/18723 | 3.82e-06 | 1.16e-04 | 22 |
GO:199074823 | Breast | DCIS | cellular detoxification | 23/1390 | 116/18723 | 1.22e-05 | 3.12e-04 | 23 |
GO:009723723 | Breast | DCIS | cellular response to toxic substance | 24/1390 | 124/18723 | 1.22e-05 | 3.12e-04 | 24 |
GO:007135622 | Breast | DCIS | cellular response to tumor necrosis factor | 33/1390 | 229/18723 | 1.84e-04 | 3.00e-03 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501418 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0501419 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0501429 | Oral cavity | LP | Amyotrophic lateral sclerosis | 197/2418 | 364/8465 | 1.25e-25 | 1.39e-23 | 8.93e-24 | 197 |
hsa030132 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
hsa0501437 | Oral cavity | LP | Amyotrophic lateral sclerosis | 197/2418 | 364/8465 | 1.25e-25 | 1.39e-23 | 8.93e-24 | 197 |
hsa030133 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDC1 | SNV | Missense_Mutation | c.2019A>C | p.Lys673Asn | p.K673N | Q9BTX1 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NDC1 | SNV | Missense_Mutation | c.978C>G | p.Ile326Met | p.I326M | Q9BTX1 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NDC1 | SNV | Missense_Mutation | novel | c.1807G>A | p.Asp603Asn | p.D603N | Q9BTX1 | protein_coding | deleterious(0) | benign(0.136) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDC1 | SNV | Missense_Mutation | novel | c.1720G>A | p.Ala574Thr | p.A574T | Q9BTX1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDC1 | SNV | Missense_Mutation | c.426T>G | p.Phe142Leu | p.F142L | Q9BTX1 | protein_coding | tolerated(0.51) | benign(0.009) | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | |
NDC1 | SNV | Missense_Mutation | c.797A>C | p.Asn266Thr | p.N266T | Q9BTX1 | protein_coding | deleterious(0.01) | possibly_damaging(0.816) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NDC1 | SNV | Missense_Mutation | c.1050C>G | p.Phe350Leu | p.F350L | Q9BTX1 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NDC1 | SNV | Missense_Mutation | c.125T>C | p.Val42Ala | p.V42A | Q9BTX1 | protein_coding | tolerated(0.49) | benign(0.005) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NDC1 | SNV | Missense_Mutation | novel | c.1807N>A | p.Asp603Asn | p.D603N | Q9BTX1 | protein_coding | deleterious(0) | benign(0.136) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDC1 | SNV | Missense_Mutation | c.859T>C | p.Ser287Pro | p.S287P | Q9BTX1 | protein_coding | deleterious(0.03) | possibly_damaging(0.658) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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