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Gene: NBPF20 |
Gene summary for NBPF20 |
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Gene information | Species | Human | Gene symbol | NBPF20 | Gene ID | 100288142 |
Gene name | NBPF member 20 | |
Gene Alias | NBPF20 | |
Cytomap | 1q21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A087WVA0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100288142 | NBPF20 | NAFLD1 | Human | Liver | NAFLD | 1.25e-08 | 5.17e-01 | -0.04 |
100288142 | NBPF20 | HCC2 | Human | Liver | HCC | 4.78e-09 | 4.87e-01 | 0.5341 |
100288142 | NBPF20 | S014 | Human | Liver | HCC | 3.43e-08 | 2.39e-01 | 0.2254 |
100288142 | NBPF20 | S016 | Human | Liver | HCC | 4.02e-03 | 1.90e-01 | 0.2243 |
100288142 | NBPF20 | S027 | Human | Liver | HCC | 2.32e-07 | 4.95e-01 | 0.2446 |
100288142 | NBPF20 | S028 | Human | Liver | HCC | 6.37e-19 | 5.93e-01 | 0.2503 |
100288142 | NBPF20 | S029 | Human | Liver | HCC | 1.54e-11 | 3.73e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBPF20 | SNV | Missense_Mutation | novel | c.702A>T | p.Arg234Ser | p.R234S | protein_coding | tolerated(0.53) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
NBPF20 | SNV | Missense_Mutation | novel | c.15358N>C | p.Asp5120His | p.D5120H | protein_coding | deleterious(0.01) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
NBPF20 | SNV | Missense_Mutation | novel | c.15324G>C | p.Lys5108Asn | p.K5108N | protein_coding | tolerated_low_confidence(0.11) | TCGA-EK-A2RK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NBPF20 | insertion | Frame_Shift_Ins | novel | c.703_704insCC | p.Lys235ThrfsTer45 | p.K235Tfs*45 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |||
NBPF20 | SNV | Missense_Mutation | novel | c.154N>T | p.Arg52Cys | p.R52C | protein_coding | deleterious(0.01) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | ||
NBPF20 | SNV | Missense_Mutation | rs375093596 | c.15538N>A | p.Ala5180Thr | p.A5180T | protein_coding | tolerated(0.34) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NBPF20 | SNV | Missense_Mutation | rs377296885 | c.15551N>G | p.Asp5184Gly | p.D5184G | protein_coding | deleterious(0.04) | TCGA-D1-A16F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NBPF20 | SNV | Missense_Mutation | novel | c.64N>T | p.Asp22Tyr | p.D22Y | protein_coding | deleterious(0) | TCGA-BC-A10X-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
NBPF20 | SNV | Missense_Mutation | rs782245518 | c.15470N>T | p.Glu5157Val | p.E5157V | protein_coding | deleterious(0) | TCGA-CC-A8HU-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
NBPF20 | SNV | Missense_Mutation | novel | c.7289G>A | p.Arg2430Lys | p.R2430K | protein_coding | tolerated(0.35) | TCGA-33-AASI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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