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Gene: NBPF11 |
Gene summary for NBPF11 |
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Gene information | Species | Human | Gene symbol | NBPF11 | Gene ID | 200030 |
Gene name | NBPF member 11 | |
Gene Alias | NBPF24 | |
Cytomap | 1q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86T75 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200030 | NBPF11 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.32e-02 | 4.44e-01 | -0.1088 |
200030 | NBPF11 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.67e-25 | 8.83e-01 | -0.1954 |
200030 | NBPF11 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.57e-04 | 3.59e-01 | -0.1464 |
200030 | NBPF11 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.53e-07 | 3.04e-01 | -0.1001 |
200030 | NBPF11 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.10e-05 | 5.27e-01 | -0.059 |
200030 | NBPF11 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.56e-04 | 4.98e-01 | -0.0842 |
200030 | NBPF11 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.86e-03 | 6.33e-01 | -0.0177 |
200030 | NBPF11 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.26e-03 | 2.13e-01 | 0.0674 |
200030 | NBPF11 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.20e-02 | 3.44e-01 | 0.294 |
200030 | NBPF11 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.98e-08 | 4.80e-01 | 0.3859 |
200030 | NBPF11 | A001-C-207 | Human | Colorectum | FAP | 2.98e-02 | -1.93e-01 | 0.1278 |
200030 | NBPF11 | A015-C-203 | Human | Colorectum | FAP | 5.24e-04 | -1.37e-01 | -0.1294 |
200030 | NBPF11 | A002-C-201 | Human | Colorectum | FAP | 8.92e-06 | -1.89e-01 | 0.0324 |
200030 | NBPF11 | A001-C-108 | Human | Colorectum | FAP | 2.58e-04 | -2.09e-01 | -0.0272 |
200030 | NBPF11 | A002-C-205 | Human | Colorectum | FAP | 1.52e-06 | -1.34e-01 | -0.1236 |
200030 | NBPF11 | A015-C-006 | Human | Colorectum | FAP | 1.38e-06 | -2.55e-01 | -0.0994 |
200030 | NBPF11 | A002-C-114 | Human | Colorectum | FAP | 4.11e-08 | -2.31e-01 | -0.1561 |
200030 | NBPF11 | A015-C-104 | Human | Colorectum | FAP | 1.42e-06 | -1.85e-01 | -0.1899 |
200030 | NBPF11 | A001-C-014 | Human | Colorectum | FAP | 2.02e-04 | -2.14e-01 | 0.0135 |
200030 | NBPF11 | A002-C-016 | Human | Colorectum | FAP | 8.30e-06 | -1.84e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBPF11 | SNV | Missense_Mutation | novel | c.865C>G | p.Leu289Val | p.L289V | Q86T75 | protein_coding | tolerated(0.06) | probably_damaging(0.952) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
NBPF11 | SNV | Missense_Mutation | novel | c.1717N>A | p.Glu573Lys | p.E573K | Q86T75 | protein_coding | tolerated(0.06) | possibly_damaging(0.874) | TCGA-C8-A26W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
NBPF11 | SNV | Missense_Mutation | novel | c.271N>A | p.Glu91Lys | p.E91K | Q86T75 | protein_coding | tolerated(0.13) | possibly_damaging(0.636) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
NBPF11 | SNV | Missense_Mutation | novel | c.877G>C | p.Glu293Gln | p.E293Q | Q86T75 | protein_coding | tolerated(0.93) | probably_damaging(0.968) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
NBPF11 | SNV | Missense_Mutation | novel | c.1876G>A | p.Glu626Lys | p.E626K | Q86T75 | protein_coding | tolerated(0.87) | benign(0.053) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD |
NBPF11 | SNV | Missense_Mutation | novel | c.1531C>T | p.Leu511Phe | p.L511F | Q86T75 | protein_coding | deleterious(0.01) | possibly_damaging(0.866) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
NBPF11 | insertion | In_Frame_Ins | novel | c.567-1_567insAGATGAACATTC | p.Arg189_Glu190insAspGluHisSer | p.R189_E190insDEHS | Q86T75 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
NBPF11 | SNV | Missense_Mutation | rs782259033 | c.73N>T | p.Arg25Cys | p.R25C | Q86T75 | protein_coding | deleterious(0.01) | possibly_damaging(0.876) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
NBPF11 | SNV | Missense_Mutation | novel | c.1876G>A | p.Glu626Lys | p.E626K | Q86T75 | protein_coding | tolerated(0.87) | benign(0.053) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NBPF11 | SNV | Missense_Mutation | rs782292042 | c.1999C>T | p.Arg667Cys | p.R667C | Q86T75 | protein_coding | deleterious(0.04) | benign(0.219) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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