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Gene: NBPF1 |
Gene summary for NBPF1 |
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Gene information | Species | Human | Gene symbol | NBPF1 | Gene ID | 55672 |
Gene name | NBPF member 1 | |
Gene Alias | AB13 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q3BBV0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55672 | NBPF1 | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 3.53e-01 | 0.082 |
55672 | NBPF1 | LZE3D | Human | Esophagus | HGIN | 6.21e-05 | 5.76e-01 | 0.0668 |
55672 | NBPF1 | LZE4T | Human | Esophagus | ESCC | 2.35e-12 | 2.80e-01 | 0.0811 |
55672 | NBPF1 | LZE5T | Human | Esophagus | ESCC | 1.54e-04 | 3.53e-01 | 0.0514 |
55672 | NBPF1 | LZE7T | Human | Esophagus | ESCC | 3.42e-17 | 5.41e-01 | 0.0667 |
55672 | NBPF1 | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 1.24e-01 | 0.067 |
55672 | NBPF1 | LZE20T | Human | Esophagus | ESCC | 6.96e-12 | 3.13e-01 | 0.0662 |
55672 | NBPF1 | LZE22D1 | Human | Esophagus | HGIN | 2.88e-06 | 2.47e-01 | 0.0595 |
55672 | NBPF1 | LZE22T | Human | Esophagus | ESCC | 1.48e-05 | 2.99e-01 | 0.068 |
55672 | NBPF1 | LZE24T | Human | Esophagus | ESCC | 2.62e-15 | 3.33e-01 | 0.0596 |
55672 | NBPF1 | LZE21T | Human | Esophagus | ESCC | 8.02e-04 | 2.90e-01 | 0.0655 |
55672 | NBPF1 | P1T-E | Human | Esophagus | ESCC | 1.98e-11 | 3.73e-01 | 0.0875 |
55672 | NBPF1 | P2T-E | Human | Esophagus | ESCC | 1.63e-36 | 5.60e-01 | 0.1177 |
55672 | NBPF1 | P4T-E | Human | Esophagus | ESCC | 6.30e-30 | 6.06e-01 | 0.1323 |
55672 | NBPF1 | P5T-E | Human | Esophagus | ESCC | 7.90e-03 | 8.78e-02 | 0.1327 |
55672 | NBPF1 | P8T-E | Human | Esophagus | ESCC | 6.62e-20 | 4.30e-01 | 0.0889 |
55672 | NBPF1 | P9T-E | Human | Esophagus | ESCC | 2.79e-12 | 3.05e-01 | 0.1131 |
55672 | NBPF1 | P10T-E | Human | Esophagus | ESCC | 1.15e-45 | 7.08e-01 | 0.116 |
55672 | NBPF1 | P11T-E | Human | Esophagus | ESCC | 7.73e-16 | 5.76e-01 | 0.1426 |
55672 | NBPF1 | P12T-E | Human | Esophagus | ESCC | 1.49e-39 | 6.65e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBPF1 | SNV | Missense_Mutation | rs749566137 | c.2031N>C | p.Glu677Asp | p.E677D | protein_coding | tolerated(0.91) | benign(0.091) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
NBPF1 | SNV | Missense_Mutation | novel | c.2336A>C | p.Asp779Ala | p.D779A | protein_coding | tolerated(0.07) | possibly_damaging(0.557) | TCGA-AC-A62X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBPF1 | SNV | Missense_Mutation | novel | c.1507G>C | p.Glu503Gln | p.E503Q | protein_coding | deleterious(0.02) | benign(0.444) | TCGA-AO-A0J3-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | SD | |
NBPF1 | SNV | Missense_Mutation | novel | c.868N>C | p.Glu290Gln | p.E290Q | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
NBPF1 | SNV | Missense_Mutation | novel | c.2029N>C | p.Glu677Gln | p.E677Q | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NBPF1 | insertion | Frame_Shift_Ins | novel | c.656_657insAAATAATGTCATC | p.Asp219GlufsTer18 | p.D219Efs*18 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | |||
NBPF1 | SNV | Missense_Mutation | rs759852954 | c.448N>A | p.Glu150Lys | p.E150K | protein_coding | tolerated(0.11) | possibly_damaging(0.801) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
NBPF1 | SNV | Missense_Mutation | novel | c.107N>A | p.Arg36Lys | p.R36K | protein_coding | tolerated(0.09) | benign(0.05) | TCGA-C5-A2LV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NBPF1 | SNV | Missense_Mutation | novel | c.1081G>A | p.Glu361Lys | p.E361K | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
NBPF1 | SNV | Missense_Mutation | novel | c.1744G>C | p.Glu582Gln | p.E582Q | protein_coding | tolerated(0.22) | possibly_damaging(0.55) | TCGA-FU-A5XV-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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