Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: NASP

Gene summary for NASP

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

NASP

Gene ID

4678

Gene namenuclear autoantigenic sperm protein
Gene AliasFLB7527
Cytomap1p34.1
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

P49321


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4678NASPHTA11_1391_2000001011HumanColorectumAD1.33e-034.86e-01-0.059
4678NASPHTA11_99999970781_79442HumanColorectumMSS2.94e-064.24e-010.294
4678NASPA015-C-203HumanColorectumFAP4.40e-031.11e-01-0.1294
4678NASPA002-C-205HumanColorectumFAP1.74e-022.18e-01-0.1236
4678NASPA015-C-104HumanColorectumFAP2.15e-041.20e-01-0.1899
4678NASPA002-C-016HumanColorectumFAP3.61e-023.13e-020.0521
4678NASPA002-C-116HumanColorectumFAP1.84e-048.74e-02-0.0452
4678NASPF034HumanColorectumFAP3.38e-032.13e-01-0.0665
4678NASPAEH-subject1HumanEndometriumAEH1.98e-031.99e-01-0.3059
4678NASPAEH-subject2HumanEndometriumAEH1.71e-05-1.17e-01-0.2525
4678NASPAEH-subject3HumanEndometriumAEH5.48e-04-2.11e-02-0.2576
4678NASPAEH-subject5HumanEndometriumAEH6.85e-05-2.09e-01-0.2953
4678NASPEEC-subject1HumanEndometriumEEC5.27e-05-3.62e-02-0.2682
4678NASPEEC-subject3HumanEndometriumEEC3.53e-20-2.58e-01-0.2525
4678NASPEEC-subject5HumanEndometriumEEC2.13e-02-2.02e-01-0.249
4678NASPGSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC7.69e-30-2.05e-01-0.1869
4678NASPGSM6177620_NYU_UCEC1_lib2_lib2HumanEndometriumEEC4.06e-21-3.00e-01-0.1875
4678NASPGSM6177620_NYU_UCEC1_lib3_lib3HumanEndometriumEEC1.94e-28-2.64e-01-0.1883
4678NASPGSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC7.07e-24-1.02e-02-0.1934
4678NASPGSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC2.11e-42-2.60e-01-0.1917
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0001701ColorectumADin utero embryonic development110/3918367/187232.36e-054.62e-04110
GO:0006325ColorectumADchromatin organization119/3918409/187234.85e-058.33e-04119
GO:0061458ColorectumADreproductive system development116/3918427/187231.11e-031.01e-02116
GO:1901654ColorectumADresponse to ketone59/3918194/187231.14e-031.04e-0259
GO:0048608ColorectumADreproductive structure development114/3918424/187231.78e-031.47e-02114
GO:0006338ColorectumADchromatin remodeling70/3918255/187237.44e-034.53e-0270
GO:00614582ColorectumMSSreproductive system development115/3467427/187239.86e-062.39e-04115
GO:00486082ColorectumMSSreproductive structure development113/3467424/187231.94e-054.18e-04113
GO:00017012ColorectumMSSin utero embryonic development99/3467367/187233.71e-057.10e-0499
GO:00063252ColorectumMSSchromatin organization107/3467409/187237.22e-051.21e-03107
GO:19016542ColorectumMSSresponse to ketone58/3467194/187237.70e-051.28e-0358
GO:00017013ColorectumFAPin utero embryonic development81/2622367/187231.58e-054.10e-0481
GO:00063253ColorectumFAPchromatin organization84/2622409/187231.62e-042.47e-0384
GO:19016544ColorectumFAPresponse to ketone45/2622194/187233.67e-044.63e-0345
GO:00614583ColorectumFAPreproductive system development85/2622427/187234.30e-045.13e-0385
GO:00486083ColorectumFAPreproductive structure development84/2622424/187235.40e-046.10e-0384
GO:00614589EndometriumAEHreproductive system development88/2100427/187239.50e-096.41e-0788
GO:00486089EndometriumAEHreproductive structure development87/2100424/187231.43e-089.12e-0787
GO:00017019EndometriumAEHin utero embryonic development73/2100367/187237.18e-072.63e-0573
GO:190165415EndometriumAEHresponse to ketone45/2100194/187231.48e-064.69e-0545
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
NASPSNVMissense_Mutationc.1682N>Tp.Ala561Valp.A561VP49321protein_codingdeleterious(0)probably_damaging(0.984)TCGA-B6-A0RM-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
NASPSNVMissense_Mutationc.1439N>Tp.Ser480Leup.S480LP49321protein_codingdeleterious(0)probably_damaging(0.994)TCGA-E2-A15S-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
NASPSNVMissense_Mutationnovelc.754G>Cp.Glu252Glnp.E252QP49321protein_codingdeleterious_low_confidence(0)benign(0.074)TCGA-PE-A5DE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
NASPdeletionFrame_Shift_Delc.639delNp.Gly215GlufsTer52p.G215Efs*52P49321protein_codingTCGA-BH-A1ES-06Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
NASPSNVMissense_Mutationc.325G>Ap.Ala109Thrp.A109TP49321protein_codingdeleterious(0.01)probably_damaging(0.996)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
NASPSNVMissense_Mutationrs201446871c.970N>Ap.Glu324Lysp.E324KP49321protein_codingdeleterious_low_confidence(0)benign(0)TCGA-C5-A1BQ-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinCR
NASPSNVMissense_Mutationc.943N>Cp.Glu315Glnp.E315QP49321protein_codingdeleterious_low_confidence(0.01)benign(0.024)TCGA-DR-A0ZM-01Cervixcervical & endocervical cancerFemale<65III/IVUnspecificCisplatinSD
NASPSNVMissense_Mutationc.1508C>Gp.Ser503Cysp.S503CP49321protein_codingdeleterious(0)possibly_damaging(0.628)TCGA-EA-A3HR-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
NASPSNVMissense_Mutationrs759202853c.463N>Cp.Glu155Glnp.E155QP49321protein_codingdeleterious(0.02)possibly_damaging(0.852)TCGA-EK-A2R8-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
NASPinsertionFrame_Shift_Insnovelc.538_539insCTAAAAATACp.Lys180ThrfsTer14p.K180Tfs*14P49321protein_codingTCGA-DS-A1OB-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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