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Gene: NAP1L6 |
Gene summary for NAP1L6 |
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Gene information | Species | Human | Gene symbol | NAP1L6 | Gene ID | 645996 |
Gene name | nucleosome assembly protein 1 like 6, pseudogene | |
Gene Alias | NAP1L6 | |
Cytomap | Xq13.2 | |
Gene Type | pseudo | GO ID | GO:0006323 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
645996 | NAP1L6 | HCC1 | Human | Liver | HCC | 4.65e-08 | 1.78e+00 | 0.5336 |
645996 | NAP1L6 | HCC2 | Human | Liver | HCC | 2.50e-30 | 2.15e+00 | 0.5341 |
645996 | NAP1L6 | HCC5 | Human | Liver | HCC | 2.77e-25 | 1.69e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAP1L6 | SNV | Missense_Mutation | novel | c.68N>G | p.Ala23Gly | p.A23G | A6NFF2 | protein_coding | tolerated(0.1) | benign(0) | TCGA-AA-3956-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NAP1L6 | SNV | Missense_Mutation | c.58G>A | p.Ala20Thr | p.A20T | A6NFF2 | protein_coding | deleterious(0.04) | benign(0.038) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NAP1L6 | SNV | Missense_Mutation | c.58N>A | p.Ala20Thr | p.A20T | A6NFF2 | protein_coding | deleterious(0.04) | benign(0.038) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
NAP1L6 | SNV | Missense_Mutation | novel | c.296A>G | p.Glu99Gly | p.E99G | A6NFF2 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NAP1L6 | SNV | Missense_Mutation | novel | c.221N>A | p.Ser74Tyr | p.S74Y | A6NFF2 | protein_coding | deleterious(0) | possibly_damaging(0.73) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NAP1L6 | SNV | Missense_Mutation | novel | c.217N>A | p.His73Asn | p.H73N | A6NFF2 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
NAP1L6 | SNV | Missense_Mutation | novel | c.161T>C | p.Leu54Pro | p.L54P | A6NFF2 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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