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Gene: NACC1 |
Gene summary for NACC1 |
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Gene information | Species | Human | Gene symbol | NACC1 | Gene ID | 112939 |
Gene name | nucleus accumbens associated 1 | |
Gene Alias | BEND8 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024R7E0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
112939 | NACC1 | LZE7T | Human | Esophagus | ESCC | 5.32e-07 | 3.69e-01 | 0.0667 |
112939 | NACC1 | LZE20T | Human | Esophagus | ESCC | 3.85e-02 | 1.19e-01 | 0.0662 |
112939 | NACC1 | P1T-E | Human | Esophagus | ESCC | 1.72e-03 | 2.67e-01 | 0.0875 |
112939 | NACC1 | P4T-E | Human | Esophagus | ESCC | 2.84e-04 | 1.11e-01 | 0.1323 |
112939 | NACC1 | P5T-E | Human | Esophagus | ESCC | 2.85e-07 | 9.08e-02 | 0.1327 |
112939 | NACC1 | P8T-E | Human | Esophagus | ESCC | 4.66e-07 | 1.93e-01 | 0.0889 |
112939 | NACC1 | P9T-E | Human | Esophagus | ESCC | 1.38e-05 | 1.30e-01 | 0.1131 |
112939 | NACC1 | P10T-E | Human | Esophagus | ESCC | 5.75e-07 | 1.76e-01 | 0.116 |
112939 | NACC1 | P12T-E | Human | Esophagus | ESCC | 1.65e-03 | 8.44e-02 | 0.1122 |
112939 | NACC1 | P15T-E | Human | Esophagus | ESCC | 6.56e-05 | 1.35e-01 | 0.1149 |
112939 | NACC1 | P21T-E | Human | Esophagus | ESCC | 1.22e-13 | 1.90e-01 | 0.1617 |
112939 | NACC1 | P22T-E | Human | Esophagus | ESCC | 9.97e-09 | 1.40e-01 | 0.1236 |
112939 | NACC1 | P23T-E | Human | Esophagus | ESCC | 7.68e-07 | 1.54e-01 | 0.108 |
112939 | NACC1 | P24T-E | Human | Esophagus | ESCC | 7.79e-07 | 7.03e-02 | 0.1287 |
112939 | NACC1 | P26T-E | Human | Esophagus | ESCC | 3.76e-06 | 1.06e-01 | 0.1276 |
112939 | NACC1 | P27T-E | Human | Esophagus | ESCC | 4.29e-03 | 8.93e-02 | 0.1055 |
112939 | NACC1 | P28T-E | Human | Esophagus | ESCC | 1.93e-17 | 3.45e-01 | 0.1149 |
112939 | NACC1 | P30T-E | Human | Esophagus | ESCC | 4.76e-07 | 1.96e-01 | 0.137 |
112939 | NACC1 | P31T-E | Human | Esophagus | ESCC | 1.43e-04 | 1.49e-01 | 0.1251 |
112939 | NACC1 | P32T-E | Human | Esophagus | ESCC | 1.81e-06 | 2.30e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NACC1 | insertion | Frame_Shift_Ins | novel | c.193_194insAGTCTGTA | p.Ala65GlufsTer29 | p.A65Efs*29 | Q96RE7 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NACC1 | SNV | Missense_Mutation | novel | c.985N>A | p.Glu329Lys | p.E329K | Q96RE7 | protein_coding | deleterious(0) | benign(0.283) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
NACC1 | SNV | Missense_Mutation | novel | c.752N>A | p.Gly251Asp | p.G251D | Q96RE7 | protein_coding | deleterious(0) | benign(0.308) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
NACC1 | SNV | Missense_Mutation | novel | c.985N>A | p.Glu329Lys | p.E329K | Q96RE7 | protein_coding | deleterious(0) | benign(0.283) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
NACC1 | SNV | Missense_Mutation | c.1262N>A | p.Arg421His | p.R421H | Q96RE7 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
NACC1 | SNV | Missense_Mutation | novel | c.856N>A | p.Glu286Lys | p.E286K | Q96RE7 | protein_coding | deleterious(0.03) | possibly_damaging(0.767) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
NACC1 | insertion | In_Frame_Ins | novel | c.1470_1471insGGACTG | p.Thr490_Thr491insGlyLeu | p.T490_T491insGL | Q96RE7 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
NACC1 | SNV | Missense_Mutation | c.1399N>A | p.Ala467Thr | p.A467T | Q96RE7 | protein_coding | deleterious(0.04) | possibly_damaging(0.569) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NACC1 | SNV | Missense_Mutation | c.1276G>A | p.Asp426Asn | p.D426N | Q96RE7 | protein_coding | deleterious(0.03) | probably_damaging(0.97) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NACC1 | SNV | Missense_Mutation | novel | c.1057N>C | p.Asn353His | p.N353H | Q96RE7 | protein_coding | tolerated(0.18) | possibly_damaging(0.851) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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