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Gene: NAA38 |
Gene summary for NAA38 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NAA38 | Gene ID | 84316 |
| Gene name | N-alpha-acetyltransferase 38, NatC auxiliary subunit | |
| Gene Alias | LSMD1 | |
| Cytomap | 17p13.1 | |
| Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | I3L3Z2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84316 | NAA38 | CA_HPV_1 | Human | Cervix | CC | 5.19e-09 | -3.05e-01 | 0.0264 |
| 84316 | NAA38 | CCI_3 | Human | Cervix | CC | 1.71e-07 | -5.59e-01 | 0.516 |
| 84316 | NAA38 | CCII_1 | Human | Cervix | CC | 3.43e-09 | -5.45e-01 | 0.3249 |
| 84316 | NAA38 | L1 | Human | Cervix | CC | 4.51e-03 | -2.59e-01 | 0.0802 |
| 84316 | NAA38 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.40e-02 | 3.42e-01 | -0.0811 |
| 84316 | NAA38 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.56e-07 | 3.95e-01 | -0.1954 |
| 84316 | NAA38 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.26e-02 | 7.18e-01 | -0.2602 |
| 84316 | NAA38 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.36e-11 | 4.44e-01 | -0.1464 |
| 84316 | NAA38 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.96e-06 | 4.15e-01 | -0.059 |
| 84316 | NAA38 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.22e-05 | 5.00e-01 | -0.1706 |
| 84316 | NAA38 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.40e-04 | 4.18e-01 | -0.2061 |
| 84316 | NAA38 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.50e-02 | 4.33e-01 | -0.0842 |
| 84316 | NAA38 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.08e-02 | 3.31e-01 | -0.0179 |
| 84316 | NAA38 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.47e-03 | 2.94e-01 | 0.096 |
| 84316 | NAA38 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.35e-05 | 5.90e-01 | -0.0177 |
| 84316 | NAA38 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.64e-04 | 3.33e-01 | 0.0674 |
| 84316 | NAA38 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.30e-03 | 2.69e-01 | 0.294 |
| 84316 | NAA38 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.92e-02 | 2.44e-01 | 0.3005 |
| 84316 | NAA38 | A015-C-203 | Human | Colorectum | FAP | 2.65e-04 | -2.20e-01 | -0.1294 |
| 84316 | NAA38 | A001-C-108 | Human | Colorectum | FAP | 2.97e-02 | -2.19e-01 | -0.0272 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NAA38 | SNV | Missense_Mutation | novel | c.319N>C | p.Asp107His | p.D107H | Q9BRA0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| NAA38 | SNV | Missense_Mutation | c.355N>T | p.Asp119Tyr | p.D119Y | Q9BRA0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| NAA38 | SNV | Missense_Mutation | novel | c.26N>T | p.Ala9Val | p.A9V | Q9BRA0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-VS-A8EC-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
| NAA38 | SNV | Missense_Mutation | c.119G>A | p.Gly40Asp | p.G40D | Q9BRA0 | protein_coding | tolerated_low_confidence(0.37) | benign(0.027) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
| NAA38 | SNV | Missense_Mutation | c.41G>T | p.Gly14Val | p.G14V | Q9BRA0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| NAA38 | SNV | Missense_Mutation | c.97N>T | p.Gly33Trp | p.G33W | Q9BRA0 | protein_coding | deleterious_low_confidence(0) | benign(0.258) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| NAA38 | SNV | Missense_Mutation | c.32C>T | p.Pro11Leu | p.P11L | Q9BRA0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-AX-A0IW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | SD | |
| NAA38 | SNV | Missense_Mutation | novel | c.389A>G | p.Gln130Arg | p.Q130R | Q9BRA0 | protein_coding | tolerated(0.07) | possibly_damaging(0.78) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| NAA38 | SNV | Missense_Mutation | rs3744250 | c.517N>T | p.Leu173Phe | p.L173F | Q9BRA0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.965) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
| NAA38 | SNV | Missense_Mutation | novel | c.144N>G | p.Cys48Trp | p.C48W | Q9BRA0 | protein_coding | tolerated_low_confidence(0.05) | benign(0.177) | TCGA-CC-A8HU-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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