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Gene: N6AMT2 |
Gene summary for N6AMT2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | N6AMT2 | Gene ID | 221143 |
Gene name | EEF1A lysine methyltransferase 1 | |
Gene Alias | ESP13 | |
Cytomap | 13q12.11 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024RDN3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221143 | N6AMT2 | P2T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.20e-01 | 0.1177 |
221143 | N6AMT2 | P4T-E | Human | Esophagus | ESCC | 1.78e-10 | 2.35e-01 | 0.1323 |
221143 | N6AMT2 | P5T-E | Human | Esophagus | ESCC | 3.97e-04 | 9.36e-02 | 0.1327 |
221143 | N6AMT2 | P8T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.28e-01 | 0.0889 |
221143 | N6AMT2 | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 1.62e-01 | 0.1131 |
221143 | N6AMT2 | P10T-E | Human | Esophagus | ESCC | 5.00e-17 | 3.17e-01 | 0.116 |
221143 | N6AMT2 | P11T-E | Human | Esophagus | ESCC | 9.07e-04 | 1.78e-01 | 0.1426 |
221143 | N6AMT2 | P12T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.01e-01 | 0.1122 |
221143 | N6AMT2 | P15T-E | Human | Esophagus | ESCC | 1.31e-02 | 9.31e-02 | 0.1149 |
221143 | N6AMT2 | P16T-E | Human | Esophagus | ESCC | 1.35e-23 | 4.12e-01 | 0.1153 |
221143 | N6AMT2 | P20T-E | Human | Esophagus | ESCC | 6.20e-06 | 1.46e-01 | 0.1124 |
221143 | N6AMT2 | P21T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.35e-01 | 0.1617 |
221143 | N6AMT2 | P22T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.61e-01 | 0.1236 |
221143 | N6AMT2 | P23T-E | Human | Esophagus | ESCC | 7.50e-13 | 2.90e-01 | 0.108 |
221143 | N6AMT2 | P24T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.72e-01 | 0.1287 |
221143 | N6AMT2 | P27T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.44e-01 | 0.1055 |
221143 | N6AMT2 | P30T-E | Human | Esophagus | ESCC | 1.89e-05 | 2.29e-01 | 0.137 |
221143 | N6AMT2 | P31T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.48e-01 | 0.1251 |
221143 | N6AMT2 | P32T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.73e-01 | 0.1666 |
221143 | N6AMT2 | P36T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.79e-01 | 0.1187 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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