![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MZT2B |
Gene summary for MZT2B |
![]() |
Gene information | Species | Human | Gene symbol | MZT2B | Gene ID | 80097 |
Gene name | mitotic spindle organizing protein 2B | |
Gene Alias | FAM128B | |
Cytomap | 2q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000930 | UniProtAcc | B8ZZ87 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80097 | MZT2B | GSM4909277 | Human | Breast | Precancer | 1.14e-04 | -9.22e-01 | 0.0177 |
80097 | MZT2B | GSM4909281 | Human | Breast | IDC | 4.75e-17 | 4.20e-01 | 0.21 |
80097 | MZT2B | GSM4909286 | Human | Breast | IDC | 2.56e-13 | 3.66e-01 | 0.1081 |
80097 | MZT2B | GSM4909290 | Human | Breast | IDC | 2.79e-02 | 2.79e-01 | 0.2096 |
80097 | MZT2B | GSM4909291 | Human | Breast | IDC | 3.15e-02 | 2.98e-01 | 0.1753 |
80097 | MZT2B | GSM4909293 | Human | Breast | IDC | 8.26e-25 | 4.70e-01 | 0.1581 |
80097 | MZT2B | GSM4909294 | Human | Breast | IDC | 3.52e-06 | 5.51e-02 | 0.2022 |
80097 | MZT2B | GSM4909296 | Human | Breast | IDC | 7.80e-17 | 1.35e-01 | 0.1524 |
80097 | MZT2B | GSM4909297 | Human | Breast | IDC | 2.88e-34 | 1.70e-01 | 0.1517 |
80097 | MZT2B | GSM4909298 | Human | Breast | IDC | 5.54e-14 | 4.02e-01 | 0.1551 |
80097 | MZT2B | GSM4909301 | Human | Breast | IDC | 4.33e-55 | 6.19e-01 | 0.1577 |
80097 | MZT2B | GSM4909302 | Human | Breast | IDC | 2.27e-05 | 2.14e-01 | 0.1545 |
80097 | MZT2B | GSM4909304 | Human | Breast | IDC | 1.33e-25 | 5.02e-01 | 0.1636 |
80097 | MZT2B | GSM4909306 | Human | Breast | IDC | 3.09e-16 | 4.15e-01 | 0.1564 |
80097 | MZT2B | GSM4909307 | Human | Breast | IDC | 7.49e-19 | 4.03e-01 | 0.1569 |
80097 | MZT2B | GSM4909308 | Human | Breast | IDC | 1.39e-23 | 5.06e-01 | 0.158 |
80097 | MZT2B | GSM4909311 | Human | Breast | IDC | 1.12e-43 | -2.20e-01 | 0.1534 |
80097 | MZT2B | GSM4909312 | Human | Breast | IDC | 2.57e-15 | 1.79e-01 | 0.1552 |
80097 | MZT2B | GSM4909315 | Human | Breast | IDC | 2.37e-27 | 5.05e-01 | 0.21 |
80097 | MZT2B | GSM4909316 | Human | Breast | IDC | 2.54e-18 | 4.75e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MZT2B | SNV | Missense_Mutation | rs773776345 | c.550N>T | p.Arg184Cys | p.R184C | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MZT2B | insertion | Frame_Shift_Ins | rs772879277 | c.614_615insG | p.Gly208ArgfsTer34 | p.G208Rfs*34 | protein_coding | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
MZT2B | insertion | Frame_Shift_Ins | novel | c.29_30insG | p.Ser12ValfsTer106 | p.S12Vfs*106 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MZT2B | SNV | Missense_Mutation | rs773776345 | c.550N>T | p.Arg184Cys | p.R184C | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
MZT2B | SNV | Missense_Mutation | novel | c.466N>T | p.Arg156Cys | p.R156C | protein_coding | tolerated(0.13) | possibly_damaging(0.685) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
MZT2B | SNV | Missense_Mutation | novel | c.275N>A | p.Pro92His | p.P92H | protein_coding | deleterious(0.01) | probably_damaging(0.937) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MZT2B | SNV | Missense_Mutation | rs1043073 | c.560N>A | p.Arg187His | p.R187H | protein_coding | deleterious(0.01) | possibly_damaging(0.86) | TCGA-BS-A0V4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MZT2B | SNV | Missense_Mutation | novel | c.427N>G | p.Thr143Ala | p.T143A | protein_coding | tolerated(0.58) | benign(0.224) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
MZT2B | insertion | Frame_Shift_Ins | rs772879277 | c.614_615insG | p.Gly208ArgfsTer34 | p.G208Rfs*34 | protein_coding | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
MZT2B | insertion | Frame_Shift_Ins | novel | c.455_456insT | p.Ser154PhefsTer88 | p.S154Ffs*88 | protein_coding | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |