GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0050796 | Colorectum | AD | regulation of insulin secretion | 54/3918 | 165/18723 | 2.60e-04 | 3.25e-03 | 54 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:0030073 | Colorectum | AD | insulin secretion | 61/3918 | 195/18723 | 4.28e-04 | 4.81e-03 | 61 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0090087 | Colorectum | AD | regulation of peptide transport | 60/3918 | 202/18723 | 1.94e-03 | 1.58e-02 | 60 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0002791 | Colorectum | AD | regulation of peptide secretion | 59/3918 | 200/18723 | 2.50e-03 | 1.92e-02 | 59 |
GO:0090276 | Colorectum | AD | regulation of peptide hormone secretion | 58/3918 | 196/18723 | 2.51e-03 | 1.92e-02 | 58 |
GO:0002790 | Colorectum | AD | peptide secretion | 69/3918 | 242/18723 | 2.97e-03 | 2.22e-02 | 69 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0032024 | Colorectum | AD | positive regulation of insulin secretion | 27/3918 | 78/18723 | 3.52e-03 | 2.54e-02 | 27 |
GO:0050714 | Colorectum | AD | positive regulation of protein secretion | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:19049512 | Colorectum | MSS | positive regulation of establishment of protein localization | 110/3467 | 319/18723 | 6.30e-12 | 9.83e-10 | 110 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYRIP | SNV | Missense_Mutation | | c.1949N>C | p.Leu650Pro | p.L650P | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
MYRIP | SNV | Missense_Mutation | | c.1665N>C | p.Gln555His | p.Q555H | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYRIP | SNV | Missense_Mutation | | c.2361N>T | p.Arg787Ser | p.R787S | Q8NFW9 | protein_coding | tolerated(0.36) | benign(0.396) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MYRIP | SNV | Missense_Mutation | | c.2263A>G | p.Ile755Val | p.I755V | Q8NFW9 | protein_coding | tolerated(0.34) | possibly_damaging(0.536) | TCGA-BH-A0BG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYRIP | SNV | Missense_Mutation | | c.348N>T | p.Gln116His | p.Q116H | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MYRIP | SNV | Missense_Mutation | | c.388N>C | p.Lys130Gln | p.K130Q | Q8NFW9 | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-D8-A1X9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
MYRIP | SNV | Missense_Mutation | novel | c.540G>T | p.Arg180Ser | p.R180S | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
MYRIP | insertion | Frame_Shift_Ins | novel | c.1541_1542insACTTCTCTCTCTTTCTCTATGGATTGCAAATGCACACAGAAAAT | p.Glu515LeufsTer52 | p.E515Lfs*52 | Q8NFW9 | protein_coding | | | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
MYRIP | insertion | Nonsense_Mutation | novel | c.1181_1182insATAAAGAGAAGCCTGAGATCCAGGCCCTGCCTCAGGGAC | p.Gly394_Ser395insTer | p.G394_S395ins* | Q8NFW9 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYRIP | SNV | Missense_Mutation | novel | c.809C>T | p.Thr270Ile | p.T270I | Q8NFW9 | protein_coding | tolerated(0.21) | benign(0.014) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |