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Gene: MYPOP |
Gene summary for MYPOP |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MYPOP | Gene ID | 339344 |
| Gene name | Myb related transcription factor, partner of profilin | |
| Gene Alias | P42pop | |
| Cytomap | 19q13.32 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q86VE0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 339344 | MYPOP | C04 | Human | Oral cavity | OSCC | 1.55e-07 | 4.28e-01 | 0.2633 |
| 339344 | MYPOP | C21 | Human | Oral cavity | OSCC | 4.03e-07 | 2.68e-01 | 0.2678 |
| 339344 | MYPOP | C30 | Human | Oral cavity | OSCC | 2.17e-17 | 6.02e-01 | 0.3055 |
| 339344 | MYPOP | C38 | Human | Oral cavity | OSCC | 2.31e-08 | 5.45e-01 | 0.172 |
| 339344 | MYPOP | C43 | Human | Oral cavity | OSCC | 3.20e-17 | 3.95e-01 | 0.1704 |
| 339344 | MYPOP | C46 | Human | Oral cavity | OSCC | 2.75e-07 | 2.23e-01 | 0.1673 |
| 339344 | MYPOP | C06 | Human | Oral cavity | OSCC | 1.10e-04 | 5.62e-01 | 0.2699 |
| 339344 | MYPOP | C08 | Human | Oral cavity | OSCC | 3.15e-10 | 2.59e-01 | 0.1919 |
| 339344 | MYPOP | C09 | Human | Oral cavity | OSCC | 3.83e-02 | 1.17e-01 | 0.1431 |
| 339344 | MYPOP | LN22 | Human | Oral cavity | OSCC | 2.42e-04 | 4.37e-01 | 0.1733 |
| 339344 | MYPOP | LN46 | Human | Oral cavity | OSCC | 3.51e-07 | 2.53e-01 | 0.1666 |
| 339344 | MYPOP | SYSMH3 | Human | Oral cavity | OSCC | 5.89e-03 | 1.52e-01 | 0.2442 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| MYPOP | CD8TEXP | Colorectum | FAP | PCSK5,MECOM,ZBTB7C, etc. | 8.82e-02 |  |
| MYPOP | CD8TEXP | Colorectum | Healthy | PCSK5,MECOM,ZBTB7C, etc. | 1.50e-01 |  |
| MYPOP | DC | Colorectum | MSS | PCSK5,MECOM,ZBTB7C, etc. | 3.98e-02 |  |
| MYPOP | CD4TN | Liver | Cirrhotic | KLRF1,CYP3A5,SRSF1, etc. | 3.10e-01 |  |
| MYPOP | CD8TEFF | Liver | Cirrhotic | KLRF1,CYP3A5,SRSF1, etc. | 9.13e-02 | |
| MYPOP | TREG | Liver | Cirrhotic | KLRF1,CYP3A5,SRSF1, etc. | 4.80e-02 | |
| MYPOP | BMEM | Liver | Healthy | KLRF1,CYP3A5,SRSF1, etc. | 6.45e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MYPOP | SNV | Missense_Mutation | c.1147C>G | p.Arg383Gly | p.R383G | Q86VE0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.972) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| MYPOP | SNV | Missense_Mutation | novel | c.133N>T | p.Arg45Cys | p.R45C | Q86VE0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MYPOP | SNV | Missense_Mutation | novel | c.173G>C | p.Gly58Ala | p.G58A | Q86VE0 | protein_coding | deleterious(0.02) | benign(0.185) | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| MYPOP | SNV | Missense_Mutation | novel | c.919C>T | p.Pro307Ser | p.P307S | Q86VE0 | protein_coding | tolerated_low_confidence(0.16) | probably_damaging(0.992) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
| MYPOP | SNV | Missense_Mutation | c.877G>A | p.Ala293Thr | p.A293T | Q86VE0 | protein_coding | deleterious(0.04) | benign(0.051) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| MYPOP | SNV | Missense_Mutation | c.742C>T | p.Arg248Trp | p.R248W | Q86VE0 | protein_coding | tolerated(0.12) | benign(0.18) | TCGA-G4-6310-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fu | SD | |
| MYPOP | deletion | Frame_Shift_Del | rs781659001 | c.1139delN | p.Pro380HisfsTer26 | p.P380Hfs*26 | Q86VE0 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| MYPOP | deletion | Frame_Shift_Del | rs768425967 | c.1109delN | p.Pro370GlnfsTer36 | p.P370Qfs*36 | Q86VE0 | protein_coding | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | ||
| MYPOP | deletion | Frame_Shift_Del | rs781659001 | c.1139delN | p.Pro380HisfsTer26 | p.P380Hfs*26 | Q86VE0 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
| MYPOP | deletion | Frame_Shift_Del | rs781659001 | c.1139delC | p.Pro380HisfsTer26 | p.P380Hfs*26 | Q86VE0 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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