Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MYO1B

Gene summary for MYO1B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MYO1B

Gene ID

4430

Gene namemyosin IB
Gene AliasMMI-alpha
Cytomap2q32.3
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

B0I1S9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4430MYO1BCA_HPV_1HumanCervixCC1.94e-03-1.20e-010.0264
4430MYO1BCCI_1HumanCervixCC6.52e-097.46e-010.528
4430MYO1BCCI_3HumanCervixCC7.32e-118.61e-010.516
4430MYO1BTumorHumanCervixCC1.81e-073.82e-010.1241
4430MYO1Bsample3HumanCervixCC9.55e-103.66e-010.1387
4430MYO1BT3HumanCervixCC9.90e-133.53e-010.1389
4430MYO1BHTA11_3410_2000001011HumanColorectumAD4.33e-15-5.71e-010.0155
4430MYO1BHTA11_2487_2000001011HumanColorectumSER8.20e-09-6.06e-01-0.1808
4430MYO1BHTA11_1938_2000001011HumanColorectumAD1.41e-02-3.88e-01-0.0811
4430MYO1BHTA11_3361_2000001011HumanColorectumAD1.90e-05-5.79e-01-0.1207
4430MYO1BHTA11_696_2000001011HumanColorectumAD1.67e-08-5.05e-01-0.1464
4430MYO1BHTA11_866_3004761011HumanColorectumAD3.66e-02-3.29e-010.096
4430MYO1BHTA11_8622_2000001021HumanColorectumSER4.60e-02-5.54e-010.0528
4430MYO1BHTA11_99999973899_84307HumanColorectumMSS8.19e-03-4.77e-010.2585
4430MYO1BHTA11_99999974143_84620HumanColorectumMSS4.77e-07-4.48e-010.3005
4430MYO1BA015-C-203HumanColorectumFAP4.49e-24-3.96e-01-0.1294
4430MYO1BA015-C-204HumanColorectumFAP1.92e-04-2.48e-01-0.0228
4430MYO1BA014-C-040HumanColorectumFAP3.01e-04-4.28e-01-0.1184
4430MYO1BA002-C-201HumanColorectumFAP1.74e-15-4.16e-010.0324
4430MYO1BA002-C-203HumanColorectumFAP1.10e-03-2.26e-010.2786
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000701510CervixCCactin filament organization109/2311442/187234.92e-132.45e-10109
GO:006157210CervixCCactin filament bundle organization44/2311161/187232.08e-079.34e-0644
GO:005101710CervixCCactin filament bundle assembly43/2311157/187232.66e-071.12e-0543
GO:00516567CervixCCestablishment of organelle localization76/2311390/187233.17e-055.21e-0476
GO:00068927CervixCCpost-Golgi vesicle-mediated transport28/2311104/187234.31e-056.61e-0428
GO:00481938CervixCCGolgi vesicle transport58/2311296/187232.24e-042.54e-0358
GO:00300487CervixCCactin filament-based movement29/2311127/187236.91e-046.33e-0329
GO:00307057CervixCCcytoskeleton-dependent intracellular transport40/2311195/187237.92e-046.99e-0340
GO:00995157CervixCCactin filament-based transport8/231121/187232.44e-031.71e-028
GO:00300507CervixCCvesicle transport along actin filament7/231119/187235.65e-033.25e-027
GO:0007015ColorectumADactin filament organization167/3918442/187231.65e-167.94e-14167
GO:0048193ColorectumADGolgi vesicle transport109/3918296/187231.80e-101.68e-08109
GO:0051656ColorectumADestablishment of organelle localization131/3918390/187233.00e-092.06e-07131
GO:0006892ColorectumADpost-Golgi vesicle-mediated transport45/3918104/187232.22e-079.26e-0645
GO:0061572ColorectumADactin filament bundle organization60/3918161/187231.33e-064.23e-0560
GO:0051017ColorectumADactin filament bundle assembly58/3918157/187232.74e-067.89e-0558
GO:0051650ColorectumADestablishment of vesicle localization57/3918161/187231.47e-053.15e-0457
GO:0051648ColorectumADvesicle localization59/3918177/187237.83e-051.25e-0359
GO:0030048ColorectumADactin filament-based movement44/3918127/187232.31e-042.99e-0344
GO:0099515ColorectumADactin filament-based transport12/391821/187233.02e-043.62e-0312
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0513020CervixCCPathogenic Escherichia coli infection63/1267197/84659.28e-102.00e-081.19e-0863
hsa05130110CervixCCPathogenic Escherichia coli infection63/1267197/84659.28e-102.00e-081.19e-0863
hsa05130ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa051301ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa051302ColorectumSERPathogenic Escherichia coli infection60/1580197/84653.63e-054.31e-043.13e-0460
hsa051303ColorectumSERPathogenic Escherichia coli infection60/1580197/84653.63e-054.31e-043.13e-0460
hsa051304ColorectumMSSPathogenic Escherichia coli infection73/1875197/84651.10e-061.48e-059.06e-0673
hsa051305ColorectumMSSPathogenic Escherichia coli infection73/1875197/84651.10e-061.48e-059.06e-0673
hsa051308ColorectumFAPPathogenic Escherichia coli infection62/1404197/84651.37e-073.08e-061.87e-0662
hsa051309ColorectumFAPPathogenic Escherichia coli infection62/1404197/84651.37e-073.08e-061.87e-0662
hsa0513010ColorectumCRCPathogenic Escherichia coli infection47/1091197/84651.49e-053.84e-042.60e-0447
hsa0513011ColorectumCRCPathogenic Escherichia coli infection47/1091197/84651.49e-053.84e-042.60e-0447
hsa05130211EsophagusESCCPathogenic Escherichia coli infection142/4205197/84658.21e-111.06e-095.42e-10142
hsa05130310EsophagusESCCPathogenic Escherichia coli infection142/4205197/84658.21e-111.06e-095.42e-10142
hsa0513014LiverNAFLDPathogenic Escherichia coli infection45/1043197/84652.31e-056.88e-045.54e-0445
hsa0513015LiverNAFLDPathogenic Escherichia coli infection45/1043197/84652.31e-056.88e-045.54e-0445
hsa0513022LiverCirrhoticPathogenic Escherichia coli infection88/2530197/84656.48e-066.24e-053.84e-0588
hsa0513032LiverCirrhoticPathogenic Escherichia coli infection88/2530197/84656.48e-066.24e-053.84e-0588
hsa0513042LiverHCCPathogenic Escherichia coli infection129/4020197/84652.02e-072.50e-061.39e-06129
hsa0513052LiverHCCPathogenic Escherichia coli infection129/4020197/84652.02e-072.50e-061.39e-06129
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MYO1BSNVMissense_Mutationnovelc.2324N>Cp.His775Prop.H775PO43795protein_codingtolerated(0.08)benign(0.445)TCGA-A8-A07R-01Breastbreast invasive carcinomaFemale>=65III/IVAncillaryzoledronicSD
MYO1BSNVMissense_Mutationc.1406N>Ap.Thr469Lysp.T469KO43795protein_codingtolerated(0.92)benign(0.001)TCGA-A8-A09A-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
MYO1BSNVMissense_Mutationc.2089N>Ap.Glu697Lysp.E697KO43795protein_codingdeleterious(0)probably_damaging(0.967)TCGA-A8-A09G-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
MYO1BSNVMissense_Mutationc.623T>Gp.Phe208Cysp.F208CO43795protein_codingdeleterious(0)probably_damaging(1)TCGA-BH-A0BL-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
MYO1BSNVMissense_Mutationc.1750A>Gp.Asn584Aspp.N584DO43795protein_codingtolerated(0.06)possibly_damaging(0.718)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MYO1BinsertionNonsense_Mutationnovelc.2325_2326insTTCAGAGGGTAGACGCTGGGTCCCGAGTCp.Gln776PhefsTer4p.Q776Ffs*4O43795protein_codingTCGA-A8-A07R-01Breastbreast invasive carcinomaFemale>=65III/IVAncillaryzoledronicSD
MYO1BinsertionIn_Frame_Insnovelc.802_803insTCTACTTTTGTATATGTTTGACAACAATAACAAAAACTTACATTAp.Ala268delinsValTyrPheCysIleCysLeuThrThrIleThrLysThrTyrIleThrp.A268delinsVYFCICLTTITKTYITO43795protein_codingTCGA-B6-A0IA-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
MYO1BSNVMissense_Mutationc.1288N>Ap.Glu430Lysp.E430KO43795protein_codingdeleterious(0)probably_damaging(0.99)TCGA-JX-A3Q0-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
MYO1BSNVMissense_Mutationc.1963N>Ap.His655Asnp.H655NO43795protein_codingtolerated(0.28)benign(0.01)TCGA-MU-A51Y-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
MYO1BSNVMissense_Mutationnovelc.2216N>Tp.Arg739Metp.R739MO43795protein_codingdeleterious(0)probably_damaging(0.95)TCGA-VS-A9U6-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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