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Gene: MVK |
Gene summary for MVK |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MVK | Gene ID | 4598 |
| Gene name | mevalonate kinase | |
| Gene Alias | LRBP | |
| Cytomap | 12q24.11 | |
| Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | B2RDU6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 4598 | MVK | LZE7T | Human | Esophagus | ESCC | 3.02e-02 | 1.85e-01 | 0.0667 |
| 4598 | MVK | LZE24T | Human | Esophagus | ESCC | 2.31e-05 | 1.95e-01 | 0.0596 |
| 4598 | MVK | P1T-E | Human | Esophagus | ESCC | 2.57e-06 | 2.49e-01 | 0.0875 |
| 4598 | MVK | P2T-E | Human | Esophagus | ESCC | 5.29e-19 | 3.44e-01 | 0.1177 |
| 4598 | MVK | P4T-E | Human | Esophagus | ESCC | 6.17e-14 | 4.22e-01 | 0.1323 |
| 4598 | MVK | P5T-E | Human | Esophagus | ESCC | 1.04e-19 | 3.46e-01 | 0.1327 |
| 4598 | MVK | P8T-E | Human | Esophagus | ESCC | 6.72e-26 | 5.38e-01 | 0.0889 |
| 4598 | MVK | P10T-E | Human | Esophagus | ESCC | 2.00e-21 | 4.53e-01 | 0.116 |
| 4598 | MVK | P11T-E | Human | Esophagus | ESCC | 1.62e-07 | 3.39e-01 | 0.1426 |
| 4598 | MVK | P12T-E | Human | Esophagus | ESCC | 1.32e-07 | 1.86e-01 | 0.1122 |
| 4598 | MVK | P15T-E | Human | Esophagus | ESCC | 4.00e-11 | 2.47e-01 | 0.1149 |
| 4598 | MVK | P16T-E | Human | Esophagus | ESCC | 6.57e-06 | 1.52e-01 | 0.1153 |
| 4598 | MVK | P17T-E | Human | Esophagus | ESCC | 3.62e-04 | 2.12e-01 | 0.1278 |
| 4598 | MVK | P19T-E | Human | Esophagus | ESCC | 4.38e-02 | 3.65e-01 | 0.1662 |
| 4598 | MVK | P20T-E | Human | Esophagus | ESCC | 2.12e-09 | 1.92e-01 | 0.1124 |
| 4598 | MVK | P21T-E | Human | Esophagus | ESCC | 4.85e-24 | 5.76e-01 | 0.1617 |
| 4598 | MVK | P22T-E | Human | Esophagus | ESCC | 1.52e-12 | 2.70e-01 | 0.1236 |
| 4598 | MVK | P23T-E | Human | Esophagus | ESCC | 5.69e-11 | 3.20e-01 | 0.108 |
| 4598 | MVK | P24T-E | Human | Esophagus | ESCC | 8.56e-04 | 1.72e-01 | 0.1287 |
| 4598 | MVK | P26T-E | Human | Esophagus | ESCC | 7.03e-18 | 3.90e-01 | 0.1276 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000915014 | Breast | IDC | purine ribonucleotide metabolic process | 55/1434 | 368/18723 | 1.30e-06 | 5.72e-05 | 55 |
| GO:001969314 | Breast | IDC | ribose phosphate metabolic process | 58/1434 | 396/18723 | 1.31e-06 | 5.73e-05 | 58 |
| GO:000675313 | Breast | IDC | nucleoside phosphate metabolic process | 68/1434 | 497/18723 | 2.01e-06 | 8.23e-05 | 68 |
| GO:000911713 | Breast | IDC | nucleotide metabolic process | 67/1434 | 489/18723 | 2.28e-06 | 9.05e-05 | 67 |
| GO:000925914 | Breast | IDC | ribonucleotide metabolic process | 56/1434 | 385/18723 | 2.47e-06 | 9.63e-05 | 56 |
| GO:000616314 | Breast | IDC | purine nucleotide metabolic process | 56/1434 | 396/18723 | 5.90e-06 | 1.90e-04 | 56 |
| GO:007252114 | Breast | IDC | purine-containing compound metabolic process | 57/1434 | 416/18723 | 1.28e-05 | 3.31e-04 | 57 |
| GO:009730514 | Breast | IDC | response to alcohol | 36/1434 | 253/18723 | 2.29e-04 | 3.64e-03 | 36 |
| GO:00066944 | Breast | IDC | steroid biosynthetic process | 25/1434 | 173/18723 | 1.56e-03 | 1.56e-02 | 25 |
| GO:001969324 | Breast | DCIS | ribose phosphate metabolic process | 58/1390 | 396/18723 | 4.80e-07 | 2.11e-05 | 58 |
| GO:000915024 | Breast | DCIS | purine ribonucleotide metabolic process | 55/1390 | 368/18723 | 4.92e-07 | 2.14e-05 | 55 |
| GO:000925924 | Breast | DCIS | ribonucleotide metabolic process | 56/1390 | 385/18723 | 9.44e-07 | 3.79e-05 | 56 |
| GO:000616324 | Breast | DCIS | purine nucleotide metabolic process | 56/1390 | 396/18723 | 2.31e-06 | 8.29e-05 | 56 |
| GO:000911723 | Breast | DCIS | nucleotide metabolic process | 65/1390 | 489/18723 | 3.19e-06 | 1.03e-04 | 65 |
| GO:007252124 | Breast | DCIS | purine-containing compound metabolic process | 57/1390 | 416/18723 | 5.07e-06 | 1.48e-04 | 57 |
| GO:000675323 | Breast | DCIS | nucleoside phosphate metabolic process | 65/1390 | 497/18723 | 5.51e-06 | 1.59e-04 | 65 |
| GO:009730524 | Breast | DCIS | response to alcohol | 34/1390 | 253/18723 | 5.54e-04 | 7.09e-03 | 34 |
| GO:000669411 | Breast | DCIS | steroid biosynthetic process | 23/1390 | 173/18723 | 4.63e-03 | 3.52e-02 | 23 |
| GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
| GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa009005 | Esophagus | ESCC | Terpenoid backbone biosynthesis | 20/4205 | 23/8465 | 2.14e-04 | 7.87e-04 | 4.03e-04 | 20 |
| hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
| hsa0090012 | Esophagus | ESCC | Terpenoid backbone biosynthesis | 20/4205 | 23/8465 | 2.14e-04 | 7.87e-04 | 4.03e-04 | 20 |
| hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
| hsa009004 | Oral cavity | OSCC | Terpenoid backbone biosynthesis | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
| hsa041466 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
| hsa0090011 | Oral cavity | OSCC | Terpenoid backbone biosynthesis | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
| hsa0414611 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MVK | SNV | Missense_Mutation | c.557A>G | p.Asn186Ser | p.N186S | Q03426 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MVK | insertion | Frame_Shift_Ins | novel | c.585_586insTTCGAGACCAGCCTGTCCAATATGGTGA | p.Ile196PhefsTer90 | p.I196Ffs*90 | Q03426 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
| MVK | SNV | Missense_Mutation | c.118N>T | p.Arg40Trp | p.R40W | Q03426 | protein_coding | deleterious(0.03) | possibly_damaging(0.795) | TCGA-AA-3818-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| MVK | SNV | Missense_Mutation | c.293N>T | p.Pro98Leu | p.P98L | Q03426 | protein_coding | deleterious(0.03) | benign(0.021) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MVK | SNV | Missense_Mutation | rs747116992 | c.449N>T | p.Ser150Leu | p.S150L | Q03426 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| MVK | SNV | Missense_Mutation | rs371789705 | c.937N>A | p.Ala313Thr | p.A313T | Q03426 | protein_coding | tolerated(0.3) | benign(0) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MVK | SNV | Missense_Mutation | rs104895358 | c.1006G>A | p.Gly336Ser | p.G336S | Q03426 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| MVK | SNV | Missense_Mutation | rs778337320 | c.317N>A | p.Arg106His | p.R106H | Q03426 | protein_coding | tolerated(0.25) | benign(0) | TCGA-EI-6513-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
| MVK | deletion | Frame_Shift_Del | c.412delN | p.Ala141ArgfsTer18 | p.A141Rfs*18 | Q03426 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| MVK | deletion | Frame_Shift_Del | c.417delC | p.Ala141ArgfsTer18 | p.A141Rfs*18 | Q03426 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 4598 | MVK | KINASE, ENZYME | inhibitor | 135651475 | ||
| 4598 | MVK | KINASE, ENZYME | inhibitor | 135651486 | FARNESOL | |
| 4598 | MVK | KINASE, ENZYME | alendronate | ALENDRONIC ACID | 25223561 | |
| 4598 | MVK | KINASE, ENZYME | inhibitor | 135651580 | ||
| 4598 | MVK | KINASE, ENZYME | inhibitor | 135650252 | ||
| 4598 | MVK | KINASE, ENZYME | inhibitor | 135651490 | ||
| 4598 | MVK | KINASE, ENZYME | inhibitor | 135651491 | ||
| 4598 | MVK | KINASE, ENZYME | inhibitor | 135651495 | ||
| 4598 | MVK | KINASE, ENZYME | inhibitor | 135650204 |
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