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Gene: MUCL1 |
Gene summary for MUCL1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MUCL1 | Gene ID | 118430 |
| Gene name | mucin like 1 | |
| Gene Alias | SBEM | |
| Cytomap | 12q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96DR8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 118430 | MUCL1 | GSM4909281 | Human | Breast | IDC | 1.86e-06 | -3.02e-01 | 0.21 |
| 118430 | MUCL1 | GSM4909282 | Human | Breast | IDC | 6.00e-06 | -2.99e-01 | -0.0288 |
| 118430 | MUCL1 | GSM4909285 | Human | Breast | IDC | 6.74e-13 | -3.26e-01 | 0.21 |
| 118430 | MUCL1 | GSM4909286 | Human | Breast | IDC | 1.49e-12 | -3.26e-01 | 0.1081 |
| 118430 | MUCL1 | GSM4909287 | Human | Breast | IDC | 3.33e-07 | -2.83e-01 | 0.2057 |
| 118430 | MUCL1 | GSM4909290 | Human | Breast | IDC | 2.38e-145 | 2.15e+00 | 0.2096 |
| 118430 | MUCL1 | GSM4909294 | Human | Breast | IDC | 1.58e-05 | 5.28e-01 | 0.2022 |
| 118430 | MUCL1 | GSM4909295 | Human | Breast | IDC | 2.48e-04 | -3.26e-01 | 0.0898 |
| 118430 | MUCL1 | GSM4909296 | Human | Breast | IDC | 1.63e-44 | 1.16e+00 | 0.1524 |
| 118430 | MUCL1 | GSM4909297 | Human | Breast | IDC | 5.51e-04 | -2.30e-01 | 0.1517 |
| 118430 | MUCL1 | GSM4909298 | Human | Breast | IDC | 6.42e-05 | -2.98e-01 | 0.1551 |
| 118430 | MUCL1 | GSM4909301 | Human | Breast | IDC | 3.52e-11 | -3.19e-01 | 0.1577 |
| 118430 | MUCL1 | GSM4909302 | Human | Breast | IDC | 3.88e-11 | -3.26e-01 | 0.1545 |
| 118430 | MUCL1 | GSM4909303 | Human | Breast | IDC | 8.76e-03 | 5.23e-01 | 0.0438 |
| 118430 | MUCL1 | GSM4909304 | Human | Breast | IDC | 2.54e-09 | -3.09e-01 | 0.1636 |
| 118430 | MUCL1 | GSM4909305 | Human | Breast | IDC | 4.66e-03 | -2.75e-01 | 0.0436 |
| 118430 | MUCL1 | GSM4909307 | Human | Breast | IDC | 6.74e-13 | -3.26e-01 | 0.1569 |
| 118430 | MUCL1 | GSM4909308 | Human | Breast | IDC | 3.01e-07 | -3.18e-01 | 0.158 |
| 118430 | MUCL1 | GSM4909311 | Human | Breast | IDC | 6.74e-13 | -3.26e-01 | 0.1534 |
| 118430 | MUCL1 | GSM4909312 | Human | Breast | IDC | 3.04e-13 | -3.20e-01 | 0.1552 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MUCL1 | SNV | Missense_Mutation | rs539263727 | c.251N>T | p.Pro84Leu | p.P84L | Q96DR8 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| MUCL1 | SNV | Missense_Mutation | rs768368179 | c.118N>A | p.Glu40Lys | p.E40K | Q96DR8 | protein_coding | tolerated_low_confidence(0.07) | benign(0.346) | TCGA-CI-6619-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
| MUCL1 | SNV | Missense_Mutation | rs545800314 | c.121N>A | p.Ala41Thr | p.A41T | Q96DR8 | protein_coding | tolerated_low_confidence(0.29) | benign(0.058) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MUCL1 | SNV | Missense_Mutation | rs539263727 | c.251C>T | p.Pro84Leu | p.P84L | Q96DR8 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MUCL1 | SNV | Missense_Mutation | novel | c.60N>T | p.Gln20His | p.Q20H | Q96DR8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.957) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
| MUCL1 | SNV | Missense_Mutation | novel | c.176C>A | p.Thr59Asn | p.T59N | Q96DR8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.881) | TCGA-67-4679-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| MUCL1 | SNV | Missense_Mutation | rs201140321 | c.65C>T | p.Pro22Leu | p.P22L | Q96DR8 | protein_coding | deleterious_low_confidence(0.01) | benign(0.013) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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