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Gene: MUC3A |
Gene summary for MUC3A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MUC3A | Gene ID | 4584 |
| Gene name | mucin 3A, cell surface associated | |
| Gene Alias | MUC-3A | |
| Cytomap | 7q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q02505 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 4584 | MUC3A | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.49e-27 | 1.05e+00 | -0.1808 |
| 4584 | MUC3A | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.07e-02 | 3.51e-01 | -0.0811 |
| 4584 | MUC3A | HTA11_347_2000001011 | Human | Colorectum | AD | 1.80e-37 | 9.77e-01 | -0.1954 |
| 4584 | MUC3A | HTA11_411_2000001011 | Human | Colorectum | SER | 1.22e-14 | 1.51e+00 | -0.2602 |
| 4584 | MUC3A | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.54e-11 | 1.11e+00 | -0.2196 |
| 4584 | MUC3A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.97e-13 | 5.99e-01 | -0.1207 |
| 4584 | MUC3A | HTA11_83_2000001011 | Human | Colorectum | SER | 1.21e-03 | 5.10e-01 | -0.1526 |
| 4584 | MUC3A | HTA11_696_2000001011 | Human | Colorectum | AD | 9.71e-55 | 1.46e+00 | -0.1464 |
| 4584 | MUC3A | HTA11_866_2000001011 | Human | Colorectum | AD | 5.43e-17 | 6.43e-01 | -0.1001 |
| 4584 | MUC3A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.69e-21 | 8.30e-01 | -0.059 |
| 4584 | MUC3A | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.18e-13 | 1.20e+00 | -0.1706 |
| 4584 | MUC3A | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.45e-04 | 4.69e-01 | -0.2061 |
| 4584 | MUC3A | HTA11_546_2000001011 | Human | Colorectum | AD | 2.90e-09 | 6.74e-01 | -0.0842 |
| 4584 | MUC3A | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.19e-04 | 4.74e-01 | -0.0179 |
| 4584 | MUC3A | HTA11_866_3004761011 | Human | Colorectum | AD | 7.58e-10 | 4.95e-01 | 0.096 |
| 4584 | MUC3A | HTA11_9408_2000001011 | Human | Colorectum | AD | 9.75e-12 | 1.12e+00 | 0.0451 |
| 4584 | MUC3A | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.42e-06 | 7.06e-01 | 0.0528 |
| 4584 | MUC3A | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.48e-04 | 8.80e-01 | 0.0131 |
| 4584 | MUC3A | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.33e-07 | 6.82e-01 | -0.0177 |
| 4584 | MUC3A | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.71e-04 | 7.38e-01 | 0.0171 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MUC3A | SNV | Missense_Mutation | novel | c.9826G>A | p.Glu3276Lys | p.E3276K | Q02505 | protein_coding | tolerated_low_confidence(0.11) | benign(0.389) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| MUC3A | SNV | Missense_Mutation | novel | c.8342N>T | p.Ser2781Phe | p.S2781F | Q02505 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.979) | TCGA-A8-A08J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| MUC3A | SNV | Missense_Mutation | novel | c.8003N>G | p.Thr2668Arg | p.T2668R | Q02505 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.857) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
| MUC3A | SNV | Missense_Mutation | novel | c.7985C>T | p.Ser2662Phe | p.S2662F | Q02505 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.721) | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
| MUC3A | SNV | Missense_Mutation | novel | c.7778N>T | p.Ser2593Phe | p.S2593F | Q02505 | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MUC3A | SNV | Missense_Mutation | novel | c.1115N>T | p.Ser372Phe | p.S372F | Q02505 | protein_coding | deleterious_low_confidence(0.01) | unknown(0) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| MUC3A | SNV | Missense_Mutation | novel | c.4718N>T | p.Thr1573Ile | p.T1573I | Q02505 | protein_coding | tolerated_low_confidence(0.12) | unknown(0) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| MUC3A | SNV | Missense_Mutation | novel | c.5768G>T | p.Arg1923Ile | p.R1923I | Q02505 | protein_coding | tolerated_low_confidence(0.26) | unknown(0) | TCGA-BH-A0B3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
| MUC3A | SNV | Missense_Mutation | novel | c.8045N>T | p.Trp2682Leu | p.W2682L | Q02505 | protein_coding | tolerated_low_confidence(0.88) | benign(0) | TCGA-EW-A1PC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
| MUC3A | SNV | Missense_Mutation | rs753787832 | c.7940C>T | p.Ser2647Leu | p.S2647L | Q02505 | protein_coding | deleterious_low_confidence(0.01) | benign(0.015) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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