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Gene: MUC20 |
Gene summary for MUC20 |
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Gene information | Species | Human | Gene symbol | MUC20 | Gene ID | 200958 |
Gene name | mucin 20, cell surface associated | |
Gene Alias | MUC-20 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8N307 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200958 | MUC20 | H2 | Human | Cervix | HSIL_HPV | 6.59e-19 | 5.53e-01 | 0.0632 |
200958 | MUC20 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.93e-03 | 2.39e-01 | -0.1808 |
200958 | MUC20 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.11e-04 | 5.74e-01 | 0.0216 |
200958 | MUC20 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.07e-14 | 5.78e-01 | -0.0811 |
200958 | MUC20 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.34e-25 | 5.77e-01 | -0.1954 |
200958 | MUC20 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.68e-03 | 5.58e-01 | -0.2602 |
200958 | MUC20 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.86e-05 | 4.96e-01 | -0.2196 |
200958 | MUC20 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-03 | 2.56e-01 | -0.1207 |
200958 | MUC20 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.62e-02 | 2.86e-01 | -0.1526 |
200958 | MUC20 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.04e-13 | 3.97e-01 | -0.1464 |
200958 | MUC20 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.67e-17 | 4.55e-01 | -0.1001 |
200958 | MUC20 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.28e-09 | 3.55e-01 | -0.059 |
200958 | MUC20 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.63e-08 | 5.74e-01 | -0.2061 |
200958 | MUC20 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.33e-05 | 4.79e-01 | -0.1462 |
200958 | MUC20 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.40e-13 | 7.37e-01 | -0.0842 |
200958 | MUC20 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.97e-04 | 5.27e-01 | -0.00410000000000005 |
200958 | MUC20 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.76e-05 | 4.25e-01 | -0.0179 |
200958 | MUC20 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.30e-06 | 2.66e-01 | 0.096 |
200958 | MUC20 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.94e-03 | 4.25e-01 | 0.0451 |
200958 | MUC20 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.78e-03 | 3.16e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00480121 | Esophagus | HGIN | hepatocyte growth factor receptor signaling pathway | 6/2587 | 13/18723 | 4.97e-03 | 4.18e-02 | 6 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC20 | SNV | Missense_Mutation | novel | c.1114G>A | p.Gly372Ser | p.G372S | Q8N307 | protein_coding | tolerated_low_confidence(0.75) | probably_damaging(0.935) | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
MUC20 | SNV | Missense_Mutation | c.1897A>G | p.Lys633Glu | p.K633E | Q8N307 | protein_coding | tolerated(0.11) | benign(0.147) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MUC20 | SNV | Missense_Mutation | c.1594G>A | p.Glu532Lys | p.E532K | Q8N307 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
MUC20 | SNV | Missense_Mutation | novel | c.1264N>G | p.Ile422Val | p.I422V | Q8N307 | protein_coding | tolerated(0.11) | benign(0.042) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MUC20 | SNV | Missense_Mutation | c.1931N>T | p.Thr644Met | p.T644M | Q8N307 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-E2-A1B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Adriamycin | SD | |
MUC20 | SNV | Missense_Mutation | c.2080G>A | p.Ala694Thr | p.A694T | Q8N307 | protein_coding | tolerated(0.33) | benign(0.007) | TCGA-E9-A1RC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
MUC20 | SNV | Missense_Mutation | c.1580G>A | p.Arg527Lys | p.R527K | Q8N307 | protein_coding | tolerated(0.93) | benign(0.001) | TCGA-EK-A3GM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
MUC20 | SNV | Missense_Mutation | novel | c.2123N>A | p.Arg708Lys | p.R708K | Q8N307 | protein_coding | tolerated(0.05) | benign(0.303) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
MUC20 | SNV | Missense_Mutation | novel | c.1601N>T | p.Ser534Leu | p.S534L | Q8N307 | protein_coding | deleterious(0.03) | possibly_damaging(0.647) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MUC20 | SNV | Missense_Mutation | c.1643N>T | p.Gly548Val | p.G548V | Q8N307 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.977) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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