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Gene: MUC2 |
Gene summary for MUC2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MUC2 | Gene ID | 4583 |
| Gene name | mucin 2, oligomeric mucus/gel-forming | |
| Gene Alias | MLP | |
| Cytomap | 11p15.5 | |
| Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 4583 | MUC2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.70e-47 | 4.34e+00 | -0.1808 |
| 4583 | MUC2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.02e-02 | 4.93e-01 | 0.0216 |
| 4583 | MUC2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.51e-17 | 1.96e+00 | -0.0811 |
| 4583 | MUC2 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.04e-36 | 2.92e+00 | -0.1088 |
| 4583 | MUC2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.14e-29 | 5.25e+00 | -0.2602 |
| 4583 | MUC2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.85e-25 | 4.93e+00 | -0.2196 |
| 4583 | MUC2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.25e-45 | 3.68e+00 | -0.1207 |
| 4583 | MUC2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.32e-10 | 2.16e+00 | -0.1526 |
| 4583 | MUC2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.94e-117 | 4.73e+00 | -0.1464 |
| 4583 | MUC2 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.24e-19 | 1.98e+00 | -0.1001 |
| 4583 | MUC2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.64e-22 | 2.11e+00 | -0.059 |
| 4583 | MUC2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.85e-11 | 2.79e+00 | -0.1462 |
| 4583 | MUC2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.71e-07 | 2.33e+00 | -0.0842 |
| 4583 | MUC2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.06e-11 | 5.23e-01 | 0.096 |
| 4583 | MUC2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.05e-09 | 1.55e+00 | 0.0446 |
| 4583 | MUC2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.41e-15 | 1.48e+00 | 0.0528 |
| 4583 | MUC2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.02e-08 | 1.03e+00 | 0.0171 |
| 4583 | MUC2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.70e-04 | 5.29e-01 | 0.0112 |
| 4583 | MUC2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.18e-04 | 5.21e-01 | 0.0588 |
| 4583 | MUC2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.92e-11 | 2.13e+00 | 0.3487 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
| GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
| GO:0030277 | Colorectum | AD | maintenance of gastrointestinal epithelium | 10/3918 | 22/18723 | 8.52e-03 | 4.97e-02 | 10 |
| GO:00018941 | Colorectum | SER | tissue homeostasis | 66/2897 | 268/18723 | 5.87e-05 | 1.37e-03 | 66 |
| GO:00602491 | Colorectum | SER | anatomical structure homeostasis | 74/2897 | 314/18723 | 1.01e-04 | 2.13e-03 | 74 |
| GO:0022600 | Colorectum | SER | digestive system process | 29/2897 | 104/18723 | 8.57e-04 | 1.05e-02 | 29 |
| GO:00602492 | Colorectum | MSS | anatomical structure homeostasis | 84/3467 | 314/18723 | 1.87e-04 | 2.64e-03 | 84 |
| GO:00018942 | Colorectum | MSS | tissue homeostasis | 72/3467 | 268/18723 | 4.53e-04 | 5.40e-03 | 72 |
| GO:00226001 | Colorectum | MSS | digestive system process | 31/3467 | 104/18723 | 3.46e-03 | 2.59e-02 | 31 |
| GO:00602493 | Colorectum | MSI-H | anatomical structure homeostasis | 38/1319 | 314/18723 | 7.73e-04 | 1.44e-02 | 38 |
| GO:00018943 | Colorectum | MSI-H | tissue homeostasis | 33/1319 | 268/18723 | 1.24e-03 | 2.00e-02 | 33 |
| GO:00302771 | Colorectum | MSI-H | maintenance of gastrointestinal epithelium | 6/1319 | 22/18723 | 3.38e-03 | 4.07e-02 | 6 |
| GO:00018944 | Colorectum | FAP | tissue homeostasis | 61/2622 | 268/18723 | 6.71e-05 | 1.28e-03 | 61 |
| GO:00602494 | Colorectum | FAP | anatomical structure homeostasis | 69/2622 | 314/18723 | 7.51e-05 | 1.37e-03 | 69 |
| GO:0010669 | Colorectum | FAP | epithelial structure maintenance | 10/2622 | 30/18723 | 5.90e-03 | 3.75e-02 | 10 |
| GO:00302772 | Colorectum | FAP | maintenance of gastrointestinal epithelium | 8/2622 | 22/18723 | 7.51e-03 | 4.47e-02 | 8 |
| GO:00226002 | Colorectum | FAP | digestive system process | 24/2622 | 104/18723 | 8.41e-03 | 4.89e-02 | 24 |
| GO:00480121 | Esophagus | HGIN | hepatocyte growth factor receptor signaling pathway | 6/2587 | 13/18723 | 4.97e-03 | 4.18e-02 | 6 |
| GO:00224078 | Lung | IAC | regulation of cell-cell adhesion | 76/2061 | 448/18723 | 8.16e-05 | 1.68e-03 | 76 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 4583 | MUC2 | DRUGGABLE GENOME | 5-FU | FLUOROURACIL | 14576935 | |
| 4583 | MUC2 | DRUGGABLE GENOME | CHONDROITIN | 12770776 | ||
| 4583 | MUC2 | DRUGGABLE GENOME | PD-98059 | CHEMBL35482 | 12391274 | |
| 4583 | MUC2 | DRUGGABLE GENOME | IFN | 16504136 | ||
| 4583 | MUC2 | DRUGGABLE GENOME | 5-AZADEOXYCYTIDINE | DECITABINE | 11368880 | |
| 4583 | MUC2 | DRUGGABLE GENOME | DEXTRAN SULFATE SODIUM | 16831596 | ||
| 4583 | MUC2 | DRUGGABLE GENOME | CHEMOPREVENTIVE AGENT | 15754327 | ||
| 4583 | MUC2 | DRUGGABLE GENOME | 5-AZA-2'-DEOXYCYTIDINE | 11893907,16112420 | ||
| 4583 | MUC2 | DRUGGABLE GENOME | GPI-0100 | 15837210 |
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