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Gene: MUC16 |
Gene summary for MUC16 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MUC16 | Gene ID | 94025 |
| Gene name | mucin 16, cell surface associated | |
| Gene Alias | CA125 | |
| Cytomap | 19p13.2 | |
| Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | B3KY81 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 94025 | MUC16 | CA_HPV_1 | Human | Cervix | CC | 3.87e-21 | -6.99e-01 | 0.0264 |
| 94025 | MUC16 | CA_HPV_2 | Human | Cervix | CC | 1.36e-10 | -5.72e-01 | 0.0391 |
| 94025 | MUC16 | CA_HPV_3 | Human | Cervix | CC | 1.28e-17 | -6.63e-01 | 0.0414 |
| 94025 | MUC16 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 1.16e-07 | -5.44e-01 | 0.0116 |
| 94025 | MUC16 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 1.62e-02 | -1.22e-01 | 0.0208 |
| 94025 | MUC16 | N_HPV_1 | Human | Cervix | N_HPV | 7.71e-16 | -6.38e-01 | 0.0079 |
| 94025 | MUC16 | N_HPV_2 | Human | Cervix | N_HPV | 5.51e-18 | -6.49e-01 | -0.0131 |
| 94025 | MUC16 | CCI_2 | Human | Cervix | CC | 2.35e-02 | -4.18e-01 | 0.5249 |
| 94025 | MUC16 | CCI_3 | Human | Cervix | CC | 7.40e-07 | -7.02e-01 | 0.516 |
| 94025 | MUC16 | CCII_1 | Human | Cervix | CC | 3.15e-09 | -6.72e-01 | 0.3249 |
| 94025 | MUC16 | Tumor | Human | Cervix | CC | 2.08e-15 | -5.63e-01 | 0.1241 |
| 94025 | MUC16 | sample1 | Human | Cervix | CC | 1.45e-02 | 1.57e-01 | 0.0959 |
| 94025 | MUC16 | sample3 | Human | Cervix | CC | 4.86e-18 | -3.16e-01 | 0.1387 |
| 94025 | MUC16 | H2 | Human | Cervix | HSIL_HPV | 2.20e-17 | 5.53e-01 | 0.0632 |
| 94025 | MUC16 | L1 | Human | Cervix | CC | 3.35e-09 | -6.70e-01 | 0.0802 |
| 94025 | MUC16 | T3 | Human | Cervix | CC | 4.45e-18 | -3.50e-01 | 0.1389 |
| 94025 | MUC16 | AEH-subject1 | Human | Endometrium | AEH | 4.25e-11 | 6.27e-01 | -0.3059 |
| 94025 | MUC16 | AEH-subject2 | Human | Endometrium | AEH | 2.06e-33 | 1.10e+00 | -0.2525 |
| 94025 | MUC16 | AEH-subject4 | Human | Endometrium | AEH | 3.51e-13 | 7.22e-01 | -0.2657 |
| 94025 | MUC16 | EEC-subject2 | Human | Endometrium | EEC | 1.81e-45 | 1.15e+00 | -0.2607 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MUC16 | SNV | Missense_Mutation | novel | c.39076N>A | p.Glu13026Lys | p.E13026K | Q8WXI7 | protein_coding | benign(0.071) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
| MUC16 | SNV | Missense_Mutation | rs372572295 | c.23866N>A | p.Asp7956Asn | p.D7956N | Q8WXI7 | protein_coding | benign(0.001) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
| MUC16 | SNV | Missense_Mutation | c.13849N>A | p.Glu4617Lys | p.E4617K | Q8WXI7 | protein_coding | possibly_damaging(0.583) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | ||
| MUC16 | SNV | Missense_Mutation | novel | c.26446N>A | p.His8816Asn | p.H8816N | Q8WXI7 | protein_coding | possibly_damaging(0.851) | TCGA-5T-A9QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
| MUC16 | SNV | Missense_Mutation | c.4591N>A | p.Asp1531Asn | p.D1531N | Q8WXI7 | protein_coding | benign(0.07) | TCGA-A1-A0SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| MUC16 | SNV | Missense_Mutation | c.15224N>T | p.Gly5075Val | p.G5075V | Q8WXI7 | protein_coding | possibly_damaging(0.685) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | ||
| MUC16 | SNV | Missense_Mutation | novel | c.27539C>T | p.Ser9180Leu | p.S9180L | Q8WXI7 | protein_coding | benign(0.005) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
| MUC16 | SNV | Missense_Mutation | novel | c.16112N>T | p.Ser5371Phe | p.S5371F | Q8WXI7 | protein_coding | possibly_damaging(0.578) | TCGA-A2-A0D0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| MUC16 | SNV | Missense_Mutation | rs776081952 | c.7694C>T | p.Thr2565Met | p.T2565M | Q8WXI7 | protein_coding | benign(0) | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | |
| MUC16 | SNV | Missense_Mutation | novel | c.7235G>A | p.Arg2412Lys | p.R2412K | Q8WXI7 | protein_coding | possibly_damaging(0.567) | TCGA-A2-A0EP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 94025 | MUC16 | DRUGGABLE GENOME | CHEMBL1742981 | ABAGOVOMAB | ||
| 94025 | MUC16 | DRUGGABLE GENOME | Oregovomab | OREGOVOMAB | 24886523 | |
| 94025 | MUC16 | DRUGGABLE GENOME | DMUC-5754A | SOFITUZUMAB VEDOTIN | ||
| 94025 | MUC16 | DRUGGABLE GENOME | opioids | |||
| 94025 | MUC16 | DRUGGABLE GENOME | DIFFERENTIATING AGENTS | 1720110 | ||
| 94025 | MUC16 | DRUGGABLE GENOME | DOCETAXEL | DOCETAXEL | 9288793,14756546 | |
| 94025 | MUC16 | DRUGGABLE GENOME | CYCLOSPORINE | CYCLOSPORINE | 12169874 | |
| 94025 | MUC16 | DRUGGABLE GENOME | N/A | |||
| 94025 | MUC16 | DRUGGABLE GENOME | TOPOTECAN | TOPOTECAN | 17227902 | |
| 94025 | MUC16 | DRUGGABLE GENOME | B43.13 | 9671143 |
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