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Gene: MTSS1L |
Gene summary for MTSS1L |
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Gene information | Species | Human | Gene symbol | MTSS1L | Gene ID | 92154 |
Gene name | MTSS I-BAR domain containing 2 | |
Gene Alias | ABBA | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0007009 | UniProtAcc | Q765P7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92154 | MTSS1L | P1T-E | Human | Esophagus | ESCC | 6.53e-06 | 3.96e-01 | 0.0875 |
92154 | MTSS1L | P2T-E | Human | Esophagus | ESCC | 3.56e-03 | 7.45e-02 | 0.1177 |
92154 | MTSS1L | P4T-E | Human | Esophagus | ESCC | 2.65e-03 | 1.67e-01 | 0.1323 |
92154 | MTSS1L | P5T-E | Human | Esophagus | ESCC | 1.68e-04 | 4.10e-02 | 0.1327 |
92154 | MTSS1L | P8T-E | Human | Esophagus | ESCC | 5.78e-15 | 3.01e-01 | 0.0889 |
92154 | MTSS1L | P10T-E | Human | Esophagus | ESCC | 3.61e-03 | 3.96e-02 | 0.116 |
92154 | MTSS1L | P11T-E | Human | Esophagus | ESCC | 3.49e-02 | 2.59e-01 | 0.1426 |
92154 | MTSS1L | P12T-E | Human | Esophagus | ESCC | 1.21e-11 | 1.79e-01 | 0.1122 |
92154 | MTSS1L | P15T-E | Human | Esophagus | ESCC | 3.49e-13 | 2.11e-01 | 0.1149 |
92154 | MTSS1L | P16T-E | Human | Esophagus | ESCC | 5.00e-06 | 9.73e-02 | 0.1153 |
92154 | MTSS1L | P19T-E | Human | Esophagus | ESCC | 9.07e-03 | 2.14e-01 | 0.1662 |
92154 | MTSS1L | P20T-E | Human | Esophagus | ESCC | 2.77e-02 | 5.92e-02 | 0.1124 |
92154 | MTSS1L | P21T-E | Human | Esophagus | ESCC | 4.10e-10 | 1.59e-01 | 0.1617 |
92154 | MTSS1L | P22T-E | Human | Esophagus | ESCC | 2.82e-09 | 1.34e-01 | 0.1236 |
92154 | MTSS1L | P23T-E | Human | Esophagus | ESCC | 4.52e-12 | 1.78e-01 | 0.108 |
92154 | MTSS1L | P24T-E | Human | Esophagus | ESCC | 3.40e-05 | 6.34e-02 | 0.1287 |
92154 | MTSS1L | P26T-E | Human | Esophagus | ESCC | 7.44e-08 | 7.81e-02 | 0.1276 |
92154 | MTSS1L | P27T-E | Human | Esophagus | ESCC | 7.83e-07 | 1.17e-01 | 0.1055 |
92154 | MTSS1L | P28T-E | Human | Esophagus | ESCC | 3.42e-12 | 2.14e-01 | 0.1149 |
92154 | MTSS1L | P30T-E | Human | Esophagus | ESCC | 6.49e-03 | 2.71e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTSS1L | SNV | Missense_Mutation | c.1090N>C | p.Thr364Pro | p.T364P | Q765P7 | protein_coding | tolerated(0.05) | possibly_damaging(0.876) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MTSS1L | SNV | Missense_Mutation | c.334N>A | p.Glu112Lys | p.E112K | Q765P7 | protein_coding | deleterious(0.01) | benign(0.281) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
MTSS1L | SNV | Missense_Mutation | novel | c.328C>T | p.Arg110Cys | p.R110C | Q765P7 | protein_coding | deleterious(0) | benign(0.029) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MTSS1L | SNV | Missense_Mutation | rs761912285 | c.2186N>A | p.Arg729His | p.R729H | Q765P7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EA-A6QX-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
MTSS1L | SNV | Missense_Mutation | rs770157588 | c.1861N>A | p.Glu621Lys | p.E621K | Q765P7 | protein_coding | tolerated(0.39) | benign(0.102) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
MTSS1L | SNV | Missense_Mutation | novel | c.768N>T | p.Trp256Cys | p.W256C | Q765P7 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MTSS1L | SNV | Missense_Mutation | rs770157588 | c.1861N>A | p.Glu621Lys | p.E621K | Q765P7 | protein_coding | tolerated(0.39) | benign(0.102) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MTSS1L | SNV | Missense_Mutation | rs138255587 | c.922N>T | p.Arg308Cys | p.R308C | Q765P7 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTSS1L | SNV | Missense_Mutation | c.1229N>T | p.Ala410Val | p.A410V | Q765P7 | protein_coding | tolerated(0.14) | benign(0.097) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MTSS1L | SNV | Missense_Mutation | rs149700961 | c.1330N>A | p.Ala444Thr | p.A444T | Q765P7 | protein_coding | tolerated(0.15) | benign(0.001) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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