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Gene: MTRNR2L8 |
Gene summary for MTRNR2L8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MTRNR2L8 | Gene ID | 100463486 |
| Gene name | MT-RNR2 like 8 | |
| Gene Alias | HN8 | |
| Cytomap | 11p15.4 | |
| Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | P0CJ75 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100463486 | MTRNR2L8 | GSM4909281 | Human | Breast | IDC | 4.66e-09 | -5.03e-01 | 0.21 |
| 100463486 | MTRNR2L8 | GSM4909282 | Human | Breast | IDC | 1.13e-03 | -3.18e-01 | -0.0288 |
| 100463486 | MTRNR2L8 | GSM4909285 | Human | Breast | IDC | 3.52e-12 | -5.40e-01 | 0.21 |
| 100463486 | MTRNR2L8 | GSM4909286 | Human | Breast | IDC | 2.00e-04 | -1.10e-01 | 0.1081 |
| 100463486 | MTRNR2L8 | GSM4909287 | Human | Breast | IDC | 5.10e-04 | 4.09e-01 | 0.2057 |
| 100463486 | MTRNR2L8 | GSM4909293 | Human | Breast | IDC | 2.75e-13 | 4.09e-01 | 0.1581 |
| 100463486 | MTRNR2L8 | GSM4909294 | Human | Breast | IDC | 1.90e-04 | -2.93e-01 | 0.2022 |
| 100463486 | MTRNR2L8 | GSM4909296 | Human | Breast | IDC | 1.08e-03 | -3.61e-01 | 0.1524 |
| 100463486 | MTRNR2L8 | GSM4909297 | Human | Breast | IDC | 9.64e-03 | -2.51e-01 | 0.1517 |
| 100463486 | MTRNR2L8 | GSM4909298 | Human | Breast | IDC | 3.40e-03 | 1.71e-02 | 0.1551 |
| 100463486 | MTRNR2L8 | GSM4909300 | Human | Breast | IDC | 4.57e-03 | 3.74e-01 | 0.0334 |
| 100463486 | MTRNR2L8 | GSM4909301 | Human | Breast | IDC | 5.50e-08 | -4.95e-01 | 0.1577 |
| 100463486 | MTRNR2L8 | GSM4909302 | Human | Breast | IDC | 1.25e-07 | -4.77e-01 | 0.1545 |
| 100463486 | MTRNR2L8 | GSM4909305 | Human | Breast | IDC | 1.64e-06 | 2.88e-01 | 0.0436 |
| 100463486 | MTRNR2L8 | GSM4909307 | Human | Breast | IDC | 3.36e-05 | -4.11e-01 | 0.1569 |
| 100463486 | MTRNR2L8 | GSM4909308 | Human | Breast | IDC | 4.17e-11 | -5.67e-01 | 0.158 |
| 100463486 | MTRNR2L8 | GSM4909311 | Human | Breast | IDC | 5.77e-17 | -4.41e-01 | 0.1534 |
| 100463486 | MTRNR2L8 | GSM4909312 | Human | Breast | IDC | 2.21e-10 | -4.81e-01 | 0.1552 |
| 100463486 | MTRNR2L8 | GSM4909313 | Human | Breast | IDC | 1.01e-04 | -4.50e-01 | 0.0391 |
| 100463486 | MTRNR2L8 | GSM4909317 | Human | Breast | IDC | 2.72e-27 | 6.92e-01 | 0.1355 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0097194 | Liver | HCC | execution phase of apoptosis | 48/7958 | 85/18723 | 6.47e-03 | 2.63e-02 | 48 |
| GO:1900117 | Liver | HCC | regulation of execution phase of apoptosis | 19/7958 | 29/18723 | 1.05e-02 | 3.89e-02 | 19 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MTRNR2L8 | SNV | Missense_Mutation | novel | c.25N>A | p.Leu9Ile | p.L9I | P0CJ75 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.578) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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