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Gene: MTL5 |
Gene summary for MTL5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MTL5 | Gene ID | 9633 |
| Gene name | testis expressed metallothionein like protein | |
| Gene Alias | CXCDC2 | |
| Cytomap | 11q13.3 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9Y4I5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9633 | MTL5 | P1T-E | Human | Esophagus | ESCC | 1.98e-11 | 5.56e-01 | 0.0875 |
| 9633 | MTL5 | P2T-E | Human | Esophagus | ESCC | 7.28e-26 | 4.87e-01 | 0.1177 |
| 9633 | MTL5 | P4T-E | Human | Esophagus | ESCC | 4.48e-22 | 4.54e-01 | 0.1323 |
| 9633 | MTL5 | P5T-E | Human | Esophagus | ESCC | 5.57e-40 | 6.96e-01 | 0.1327 |
| 9633 | MTL5 | P12T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.83e-01 | 0.1122 |
| 9633 | MTL5 | P15T-E | Human | Esophagus | ESCC | 9.51e-20 | 4.95e-01 | 0.1149 |
| 9633 | MTL5 | P16T-E | Human | Esophagus | ESCC | 1.75e-25 | 4.51e-01 | 0.1153 |
| 9633 | MTL5 | P17T-E | Human | Esophagus | ESCC | 4.48e-07 | 2.69e-01 | 0.1278 |
| 9633 | MTL5 | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 2.82e-01 | 0.1662 |
| 9633 | MTL5 | P21T-E | Human | Esophagus | ESCC | 5.68e-24 | 4.42e-01 | 0.1617 |
| 9633 | MTL5 | P22T-E | Human | Esophagus | ESCC | 7.66e-49 | 7.71e-01 | 0.1236 |
| 9633 | MTL5 | P23T-E | Human | Esophagus | ESCC | 2.24e-10 | 2.56e-01 | 0.108 |
| 9633 | MTL5 | P24T-E | Human | Esophagus | ESCC | 3.02e-26 | 6.86e-01 | 0.1287 |
| 9633 | MTL5 | P26T-E | Human | Esophagus | ESCC | 2.79e-80 | 1.26e+00 | 0.1276 |
| 9633 | MTL5 | P27T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.85e-02 | 0.1055 |
| 9633 | MTL5 | P28T-E | Human | Esophagus | ESCC | 1.72e-54 | 1.03e+00 | 0.1149 |
| 9633 | MTL5 | P30T-E | Human | Esophagus | ESCC | 2.13e-03 | 1.61e-01 | 0.137 |
| 9633 | MTL5 | P31T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.34e-01 | 0.1251 |
| 9633 | MTL5 | P32T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.33e-01 | 0.1666 |
| 9633 | MTL5 | P36T-E | Human | Esophagus | ESCC | 1.14e-17 | 5.12e-01 | 0.1187 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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