|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: MTIF3 |
Gene summary for MTIF3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MTIF3 | Gene ID | 219402 |
| Gene name | mitochondrial translational initiation factor 3 | |
| Gene Alias | IF3mt | |
| Cytomap | 13q12.2 | |
| Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9H2K0 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 219402 | MTIF3 | LZE4T | Human | Esophagus | ESCC | 1.85e-06 | 1.97e-01 | 0.0811 |
| 219402 | MTIF3 | LZE5T | Human | Esophagus | ESCC | 7.20e-04 | 3.29e-01 | 0.0514 |
| 219402 | MTIF3 | LZE7T | Human | Esophagus | ESCC | 4.55e-03 | 2.67e-01 | 0.0667 |
| 219402 | MTIF3 | LZE8T | Human | Esophagus | ESCC | 9.35e-05 | 1.67e-01 | 0.067 |
| 219402 | MTIF3 | LZE20T | Human | Esophagus | ESCC | 1.19e-05 | 4.11e-02 | 0.0662 |
| 219402 | MTIF3 | LZE24T | Human | Esophagus | ESCC | 9.49e-15 | 4.25e-01 | 0.0596 |
| 219402 | MTIF3 | P1T-E | Human | Esophagus | ESCC | 2.13e-11 | 3.31e-01 | 0.0875 |
| 219402 | MTIF3 | P2T-E | Human | Esophagus | ESCC | 1.64e-21 | 3.15e-01 | 0.1177 |
| 219402 | MTIF3 | P4T-E | Human | Esophagus | ESCC | 2.79e-14 | 3.25e-01 | 0.1323 |
| 219402 | MTIF3 | P5T-E | Human | Esophagus | ESCC | 1.68e-13 | 1.69e-01 | 0.1327 |
| 219402 | MTIF3 | P8T-E | Human | Esophagus | ESCC | 3.60e-31 | 6.75e-01 | 0.0889 |
| 219402 | MTIF3 | P9T-E | Human | Esophagus | ESCC | 5.21e-24 | 4.41e-01 | 0.1131 |
| 219402 | MTIF3 | P10T-E | Human | Esophagus | ESCC | 1.29e-20 | 3.12e-01 | 0.116 |
| 219402 | MTIF3 | P11T-E | Human | Esophagus | ESCC | 3.64e-14 | 4.75e-01 | 0.1426 |
| 219402 | MTIF3 | P12T-E | Human | Esophagus | ESCC | 3.25e-18 | 1.92e-01 | 0.1122 |
| 219402 | MTIF3 | P15T-E | Human | Esophagus | ESCC | 3.99e-18 | 4.44e-01 | 0.1149 |
| 219402 | MTIF3 | P16T-E | Human | Esophagus | ESCC | 2.52e-12 | 1.48e-01 | 0.1153 |
| 219402 | MTIF3 | P17T-E | Human | Esophagus | ESCC | 2.09e-08 | 3.38e-01 | 0.1278 |
| 219402 | MTIF3 | P19T-E | Human | Esophagus | ESCC | 1.84e-04 | 6.69e-01 | 0.1662 |
| 219402 | MTIF3 | P20T-E | Human | Esophagus | ESCC | 4.55e-18 | 4.22e-01 | 0.1124 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
| GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
| GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
| GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
| GO:190300816 | Esophagus | ESCC | organelle disassembly | 89/8552 | 114/18723 | 1.36e-12 | 5.80e-11 | 89 |
| GO:000641312 | Liver | Cirrhotic | translational initiation | 76/4634 | 118/18723 | 8.36e-20 | 2.18e-17 | 76 |
| GO:00224117 | Liver | Cirrhotic | cellular component disassembly | 182/4634 | 443/18723 | 1.59e-14 | 1.54e-12 | 182 |
| GO:19030084 | Liver | Cirrhotic | organelle disassembly | 59/4634 | 114/18723 | 4.82e-10 | 2.27e-08 | 59 |
| GO:0032543 | Liver | Cirrhotic | mitochondrial translation | 40/4634 | 76/18723 | 1.61e-07 | 4.29e-06 | 40 |
| GO:0140053 | Liver | Cirrhotic | mitochondrial gene expression | 49/4634 | 108/18723 | 2.35e-06 | 4.31e-05 | 49 |
| GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
| GO:000641322 | Liver | HCC | translational initiation | 94/7958 | 118/18723 | 1.39e-16 | 1.24e-14 | 94 |
| GO:190300811 | Liver | HCC | organelle disassembly | 89/7958 | 114/18723 | 8.68e-15 | 5.73e-13 | 89 |
| GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
| GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
| GO:002241119 | Oral cavity | OSCC | cellular component disassembly | 283/7305 | 443/18723 | 9.57e-27 | 3.37e-24 | 283 |
| GO:000641318 | Oral cavity | OSCC | translational initiation | 96/7305 | 118/18723 | 4.02e-21 | 7.06e-19 | 96 |
| GO:19030088 | Oral cavity | OSCC | organelle disassembly | 85/7305 | 114/18723 | 1.15e-14 | 6.93e-13 | 85 |
| GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
| GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
| Page: 1 2 3 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MTIF3 | SNV | Missense_Mutation | c.93N>T | p.Lys31Asn | p.K31N | Q9H2K0 | protein_coding | tolerated(0.19) | benign(0.007) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
| MTIF3 | deletion | In_Frame_Del | c.624_626delNNN | p.Ile209del | p.I209del | Q9H2K0 | protein_coding | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
| MTIF3 | SNV | Missense_Mutation | novel | c.210N>T | p.Lys70Asn | p.K70N | Q9H2K0 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
| MTIF3 | SNV | Missense_Mutation | c.473G>T | p.Arg158Ile | p.R158I | Q9H2K0 | protein_coding | tolerated(0.62) | benign(0) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| MTIF3 | SNV | Missense_Mutation | rs777543756 | c.305G>A | p.Arg102Gln | p.R102Q | Q9H2K0 | protein_coding | deleterious(0.02) | possibly_damaging(0.796) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MTIF3 | SNV | Missense_Mutation | novel | c.388N>T | p.Leu130Phe | p.L130F | Q9H2K0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
| MTIF3 | SNV | Missense_Mutation | c.824N>C | p.Val275Ala | p.V275A | Q9H2K0 | protein_coding | tolerated(0.47) | benign(0) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
| MTIF3 | SNV | Missense_Mutation | rs150437746 | c.254N>A | p.Arg85Gln | p.R85Q | Q9H2K0 | protein_coding | tolerated(0.05) | probably_damaging(0.993) | TCGA-B5-A0K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
| MTIF3 | SNV | Missense_Mutation | novel | c.679N>T | p.Pro227Ser | p.P227S | Q9H2K0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MTIF3 | SNV | Missense_Mutation | novel | c.245N>A | p.Ile82Asn | p.I82N | Q9H2K0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |