Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MTCH2

Gene summary for MTCH2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MTCH2

Gene ID

23788

Gene namemitochondrial carrier 2
Gene AliasHSPC032
Cytomap11p11.2
Gene Typeprotein-coding
GO ID

GO:0006915

UniProtAcc

Q9Y6C9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23788MTCH2HTA11_347_2000001011HumanColorectumAD1.44e-166.55e-01-0.1954
23788MTCH2HTA11_83_2000001011HumanColorectumSER1.58e-056.22e-01-0.1526
23788MTCH2HTA11_1391_2000001011HumanColorectumAD4.13e-034.34e-01-0.059
23788MTCH2HTA11_99999965104_69814HumanColorectumMSS6.00e-044.88e-010.281
23788MTCH2HTA11_99999971662_82457HumanColorectumMSS3.34e-035.35e-010.3859
23788MTCH2A001-C-207HumanColorectumFAP3.63e-03-3.05e-010.1278
23788MTCH2A015-C-203HumanColorectumFAP7.39e-18-2.13e-01-0.1294
23788MTCH2A015-C-204HumanColorectumFAP7.14e-03-1.88e-01-0.0228
23788MTCH2A002-C-201HumanColorectumFAP2.66e-06-2.18e-010.0324
23788MTCH2A002-C-203HumanColorectumFAP8.10e-06-1.91e-010.2786
23788MTCH2A001-C-119HumanColorectumFAP4.78e-03-2.88e-01-0.1557
23788MTCH2A001-C-108HumanColorectumFAP3.69e-12-2.34e-01-0.0272
23788MTCH2A002-C-205HumanColorectumFAP2.27e-13-3.64e-01-0.1236
23788MTCH2A001-C-104HumanColorectumFAP8.93e-03-1.90e-010.0184
23788MTCH2A015-C-006HumanColorectumFAP6.98e-08-3.21e-01-0.0994
23788MTCH2A015-C-106HumanColorectumFAP1.83e-08-2.32e-01-0.0511
23788MTCH2A002-C-114HumanColorectumFAP2.05e-09-2.61e-01-0.1561
23788MTCH2A015-C-104HumanColorectumFAP1.02e-18-2.91e-01-0.1899
23788MTCH2A001-C-014HumanColorectumFAP4.77e-11-2.47e-010.0135
23788MTCH2A002-C-016HumanColorectumFAP3.03e-10-2.45e-010.0521
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0070585ColorectumADprotein localization to mitochondrion51/3918125/187233.40e-071.33e-0551
GO:00705851ColorectumSERprotein localization to mitochondrion42/2897125/187233.75e-071.98e-0542
GO:00705852ColorectumMSSprotein localization to mitochondrion47/3467125/187233.98e-071.58e-0547
GO:007058520EsophagusHGINprotein localization to mitochondrion43/2587125/187234.43e-093.03e-0743
GO:0070585110EsophagusESCCprotein localization to mitochondrion100/8552125/187232.96e-151.77e-13100
GO:00705857LiverCirrhoticprotein localization to mitochondrion65/4634125/187234.91e-112.77e-0965
GO:007058512LiverHCCprotein localization to mitochondrion101/7958125/187231.53e-181.86e-16101
GO:007058518Oral cavityOSCCprotein localization to mitochondrion91/7305125/187231.60e-149.27e-1391
GO:007058519Oral cavityLPprotein localization to mitochondrion70/4623125/187236.73e-147.02e-1270
GO:007058516ProstateBPHprotein localization to mitochondrion43/3107125/187239.29e-071.70e-0543
GO:007058517ProstateTumorprotein localization to mitochondrion47/3246125/187235.20e-081.58e-0647
GO:007058524SkinAKprotein localization to mitochondrion26/1910125/187233.17e-043.24e-0326
GO:007058525SkincSCCprotein localization to mitochondrion74/4864125/187233.95e-153.06e-1374
GO:0070585112ThyroidPTCprotein localization to mitochondrion83/5968125/187232.15e-151.56e-1383
GO:007058533ThyroidATCprotein localization to mitochondrion83/6293125/187236.24e-143.37e-1283
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MTCH2SNVMissense_Mutationnovelc.173N>Gp.Ala58Glyp.A58GQ9Y6C9protein_codingdeleterious(0)benign(0.414)TCGA-A8-A07W-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyexemestaneSD
MTCH2SNVMissense_Mutationc.645N>Cp.Met215Ilep.M215IQ9Y6C9protein_codingtolerated(0.07)benign(0.017)TCGA-D8-A1JA-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinPD
MTCH2SNVMissense_Mutationnovelc.173N>Gp.Ala58Glyp.A58GQ9Y6C9protein_codingdeleterious(0)benign(0.414)TCGA-E2-A15G-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
MTCH2SNVMissense_Mutationrs530710316c.553N>Tp.Arg185Cysp.R185CQ9Y6C9protein_codingdeleterious(0.02)probably_damaging(0.988)TCGA-VS-A9UD-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinCR
MTCH2insertionFrame_Shift_Insnovelc.183_184insTp.Ala62CysfsTer29p.A62Cfs*29Q9Y6C9protein_codingTCGA-VS-A9UT-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
MTCH2SNVMissense_Mutationc.392N>Ap.Arg131Hisp.R131HQ9Y6C9protein_codingdeleterious(0.01)benign(0.149)TCGA-A6-4105-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
MTCH2SNVMissense_Mutationrs749975225c.239N>Tp.Ser80Leup.S80LQ9Y6C9protein_codingdeleterious(0)possibly_damaging(0.627)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
MTCH2SNVMissense_Mutationc.583N>Ap.Leu195Metp.L195MQ9Y6C9protein_codingtolerated(0.11)possibly_damaging(0.588)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
MTCH2insertionIn_Frame_Insnovelc.178_179insTTTCTGGTTTCTTTTGTTATGCTCTGAp.His60delinsLeuSerGlyPhePheCysTyrAlaLeuAsnp.H60delinsLSGFFCYALNQ9Y6C9protein_codingTCGA-G4-6317-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapyfluorouracilPD
MTCH2SNVMissense_Mutationrs774323410c.358N>Ap.Val120Ilep.V120IQ9Y6C9protein_codingtolerated(0.06)benign(0.2)TCGA-AP-A056-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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