Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:0043281 | Colorectum | AD | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 72/3918 | 209/18723 | 3.70e-06 | 1.03e-04 | 72 |
GO:2000116 | Colorectum | AD | regulation of cysteine-type endopeptidase activity | 79/3918 | 235/18723 | 3.74e-06 | 1.03e-04 | 79 |
GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
GO:0010952 | Colorectum | AD | positive regulation of peptidase activity | 68/3918 | 197/18723 | 6.30e-06 | 1.59e-04 | 68 |
GO:0052548 | Colorectum | AD | regulation of endopeptidase activity | 124/3918 | 432/18723 | 6.58e-05 | 1.07e-03 | 124 |
GO:0010950 | Colorectum | AD | positive regulation of endopeptidase activity | 59/3918 | 179/18723 | 1.11e-04 | 1.65e-03 | 59 |
GO:2001056 | Colorectum | AD | positive regulation of cysteine-type endopeptidase activity | 47/3918 | 148/18723 | 1.30e-03 | 1.14e-02 | 47 |
GO:0043280 | Colorectum | AD | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 42/3918 | 129/18723 | 1.33e-03 | 1.16e-02 | 42 |
GO:00458621 | Colorectum | SER | positive regulation of proteolysis | 106/2897 | 372/18723 | 8.40e-11 | 1.20e-08 | 106 |
GO:00525471 | Colorectum | SER | regulation of peptidase activity | 114/2897 | 461/18723 | 1.18e-07 | 7.17e-06 | 114 |
GO:00525481 | Colorectum | SER | regulation of endopeptidase activity | 103/2897 | 432/18723 | 2.86e-06 | 1.16e-04 | 103 |
GO:00109521 | Colorectum | SER | positive regulation of peptidase activity | 55/2897 | 197/18723 | 5.44e-06 | 2.00e-04 | 55 |
GO:00432811 | Colorectum | SER | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 57/2897 | 209/18723 | 8.08e-06 | 2.74e-04 | 57 |
GO:20001161 | Colorectum | SER | regulation of cysteine-type endopeptidase activity | 62/2897 | 235/18723 | 1.05e-05 | 3.39e-04 | 62 |
GO:00109501 | Colorectum | SER | positive regulation of endopeptidase activity | 47/2897 | 179/18723 | 1.32e-04 | 2.66e-03 | 47 |
GO:00432801 | Colorectum | SER | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 33/2897 | 129/18723 | 1.97e-03 | 1.97e-02 | 33 |
GO:20010561 | Colorectum | SER | positive regulation of cysteine-type endopeptidase activity | 36/2897 | 148/18723 | 3.21e-03 | 2.76e-02 | 36 |
GO:0006919 | Colorectum | SER | activation of cysteine-type endopeptidase activity involved in apoptotic process | 21/2897 | 78/18723 | 6.50e-03 | 4.66e-02 | 21 |
GO:00458622 | Colorectum | MSS | positive regulation of proteolysis | 119/3467 | 372/18723 | 2.14e-10 | 2.09e-08 | 119 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTCH1 | SNV | Missense_Mutation | | c.1070T>C | p.Ile357Thr | p.I357T | Q9NZJ7 | protein_coding | tolerated(0.11) | possibly_damaging(0.702) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD |
MTCH1 | SNV | Missense_Mutation | | c.901N>G | p.Ser301Ala | p.S301A | Q9NZJ7 | protein_coding | tolerated_low_confidence(0.12) | benign(0.18) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
MTCH1 | insertion | Frame_Shift_Ins | novel | c.961_962insCAGTACCAACCTTGGGTTCTCGTGTTCTG | p.Val321AlafsTer11 | p.V321Afs*11 | Q9NZJ7 | protein_coding | | | TCGA-A7-A0CD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
MTCH1 | SNV | Missense_Mutation | | c.182N>T | p.Ser61Leu | p.S61L | Q9NZJ7 | protein_coding | deleterious_low_confidence(0.05) | benign(0.025) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MTCH1 | SNV | Missense_Mutation | novel | c.685N>T | p.Arg229Trp | p.R229W | Q9NZJ7 | protein_coding | tolerated(0.07) | benign(0.04) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTCH1 | SNV | Missense_Mutation | novel | c.902C>T | p.Ser301Phe | p.S301F | Q9NZJ7 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.477) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MTCH1 | SNV | Missense_Mutation | | c.1068N>T | p.Trp356Cys | p.W356C | Q9NZJ7 | protein_coding | deleterious(0) | possibly_damaging(0.584) | TCGA-DM-A28C-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MTCH1 | SNV | Missense_Mutation | | c.1133G>A | p.Arg378His | p.R378H | Q9NZJ7 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTCH1 | SNV | Missense_Mutation | novel | c.1072N>T | p.His358Tyr | p.H358Y | Q9NZJ7 | protein_coding | deleterious(0.02) | possibly_damaging(0.651) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTCH1 | SNV | Missense_Mutation | | c.871G>T | p.Gly291Trp | p.G291W | Q9NZJ7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.157) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |