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Gene: MSH5 |
Gene summary for MSH5 |
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Gene information | Species | Human | Gene symbol | MSH5 | Gene ID | 4439 |
Gene name | mutS homolog 5 | |
Gene Alias | G7 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024RCM1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4439 | MSH5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.08e-08 | 1.88e-01 | 0.0155 |
4439 | MSH5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.88e-04 | 1.71e-01 | -0.1808 |
4439 | MSH5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.51e-07 | 2.87e-01 | -0.0811 |
4439 | MSH5 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.58e-08 | 2.34e-01 | -0.1088 |
4439 | MSH5 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.61e-17 | 3.48e-01 | -0.1954 |
4439 | MSH5 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.12e-08 | 3.09e-01 | -0.1526 |
4439 | MSH5 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.19e-14 | 3.05e-01 | -0.1464 |
4439 | MSH5 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.19e-14 | 2.78e-01 | -0.1001 |
4439 | MSH5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.12e-18 | 4.15e-01 | -0.059 |
4439 | MSH5 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-07 | 3.33e-01 | -0.0842 |
4439 | MSH5 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.01e-04 | 3.31e-01 | -0.00410000000000005 |
4439 | MSH5 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.36e-06 | 2.70e-01 | -0.0179 |
4439 | MSH5 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.84e-09 | 2.33e-01 | 0.096 |
4439 | MSH5 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.22e-05 | 2.80e-01 | 0.0446 |
4439 | MSH5 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.95e-07 | 3.07e-01 | 0.0528 |
4439 | MSH5 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.58e-06 | 3.83e-01 | 0.0131 |
4439 | MSH5 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.36e-03 | 2.26e-01 | -0.0177 |
4439 | MSH5 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.04e-03 | 2.69e-01 | 0.0171 |
4439 | MSH5 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.62e-09 | 2.48e-01 | 0.0338 |
4439 | MSH5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.52e-13 | 3.12e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MSH5 | SNV | Missense_Mutation | rs766742261 | c.1901G>A | p.Arg634Gln | p.R634Q | O43196 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MSH5 | SNV | Missense_Mutation | rs763472304 | c.2461N>A | p.Val821Ile | p.V821I | O43196 | protein_coding | tolerated(0.19) | benign(0) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MSH5 | SNV | Missense_Mutation | novel | c.2309N>T | p.Ala770Val | p.A770V | O43196 | protein_coding | tolerated(0.25) | benign(0.062) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
MSH5 | SNV | Missense_Mutation | rs777829104 | c.859N>T | p.Arg287Cys | p.R287C | O43196 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
MSH5 | SNV | Missense_Mutation | c.1603N>G | p.Leu535Val | p.L535V | O43196 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-D8-A1XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MSH5 | SNV | Missense_Mutation | c.1670N>A | p.Arg557Gln | p.R557Q | O43196 | protein_coding | tolerated(0.31) | benign(0.068) | TCGA-E2-A14Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD | |
MSH5 | SNV | Missense_Mutation | c.2443N>T | p.Pro815Ser | p.P815S | O43196 | protein_coding | tolerated(0.11) | benign(0.257) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
MSH5 | SNV | Missense_Mutation | rs544248641 | c.509N>T | p.Ser170Phe | p.S170F | O43196 | protein_coding | deleterious(0) | possibly_damaging(0.722) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
MSH5 | insertion | Frame_Shift_Ins | novel | c.2279_2280insGATACACTGTCTTTTATTCTCTTTTAAGACCATGGAGA | p.Gln761IlefsTer31 | p.Q761Ifs*31 | O43196 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MSH5 | insertion | In_Frame_Ins | novel | c.1877_1878insAGGGGCTGGAGGTGGGGTTAGAAAGAT | p.Gly626_Ala627insGlyAlaGlyGlyGlyValArgLysMet | p.G626_A627insGAGGGVRKM | O43196 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4439 | MSH5 | NA | gemcitabine | GEMCITABINE | 31616045 | |
4439 | MSH5 | NA | carboplatin | CARBOPLATIN | 31616045 |
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