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Gene: MSANTD3 |
Gene summary for MSANTD3 |
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Gene information | Species | Human | Gene symbol | MSANTD3 | Gene ID | 91283 |
Gene name | Myb/SANT DNA binding domain containing 3 | |
Gene Alias | C9orf30 | |
Cytomap | 9q31.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024R171 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91283 | MSANTD3 | GSM5276934 | Human | Endometrium | EEC | 3.05e-10 | 3.69e-01 | -0.0913 |
91283 | MSANTD3 | GSM5276937 | Human | Endometrium | EEC | 1.06e-19 | 5.12e-01 | -0.0897 |
91283 | MSANTD3 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.87e-06 | -2.15e-02 | -0.1869 |
91283 | MSANTD3 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 7.72e-05 | 3.83e-02 | -0.1875 |
91283 | MSANTD3 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.02e-08 | 1.92e-02 | -0.1883 |
91283 | MSANTD3 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.15e-05 | -6.96e-02 | -0.1917 |
91283 | MSANTD3 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 7.69e-08 | -8.40e-02 | -0.1916 |
91283 | MSANTD3 | LZE4T | Human | Esophagus | ESCC | 5.59e-05 | 1.91e-01 | 0.0811 |
91283 | MSANTD3 | LZE24T | Human | Esophagus | ESCC | 3.03e-04 | 5.63e-02 | 0.0596 |
91283 | MSANTD3 | P1T-E | Human | Esophagus | ESCC | 4.32e-05 | 1.15e-01 | 0.0875 |
91283 | MSANTD3 | P2T-E | Human | Esophagus | ESCC | 5.65e-16 | 4.03e-01 | 0.1177 |
91283 | MSANTD3 | P4T-E | Human | Esophagus | ESCC | 1.34e-19 | 4.57e-01 | 0.1323 |
91283 | MSANTD3 | P5T-E | Human | Esophagus | ESCC | 9.84e-17 | 3.67e-01 | 0.1327 |
91283 | MSANTD3 | P8T-E | Human | Esophagus | ESCC | 6.69e-06 | 9.94e-02 | 0.0889 |
91283 | MSANTD3 | P9T-E | Human | Esophagus | ESCC | 1.64e-13 | 2.43e-01 | 0.1131 |
91283 | MSANTD3 | P10T-E | Human | Esophagus | ESCC | 4.48e-16 | 9.81e-02 | 0.116 |
91283 | MSANTD3 | P11T-E | Human | Esophagus | ESCC | 3.02e-10 | 3.46e-01 | 0.1426 |
91283 | MSANTD3 | P12T-E | Human | Esophagus | ESCC | 1.46e-12 | 6.98e-02 | 0.1122 |
91283 | MSANTD3 | P15T-E | Human | Esophagus | ESCC | 6.96e-07 | 1.87e-01 | 0.1149 |
91283 | MSANTD3 | P16T-E | Human | Esophagus | ESCC | 1.15e-03 | 4.07e-02 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MSANTD3 | SNV | Missense_Mutation | novel | c.163N>A | p.Glu55Lys | p.E55K | Q96H12 | protein_coding | tolerated(0.08) | possibly_damaging(0.671) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs773424982 | c.173C>T | p.Ser58Phe | p.S58F | Q96H12 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-E2-A14X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
MSANTD3 | SNV | Missense_Mutation | c.401N>A | p.Pro134His | p.P134H | Q96H12 | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MSANTD3 | SNV | Missense_Mutation | novel | c.194N>A | p.Arg65Gln | p.R65Q | Q96H12 | protein_coding | deleterious(0.01) | possibly_damaging(0.48) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs533234800 | c.13N>A | p.Glu5Lys | p.E5K | Q96H12 | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.905) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
MSANTD3 | SNV | Missense_Mutation | c.91N>A | p.Val31Met | p.V31M | Q96H12 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MSANTD3 | SNV | Missense_Mutation | rs367876098 | c.451N>A | p.Asp151Asn | p.D151N | Q96H12 | protein_coding | deleterious_low_confidence(0) | benign(0.021) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs776217356 | c.406G>A | p.Ala136Thr | p.A136T | Q96H12 | protein_coding | tolerated_low_confidence(0.09) | benign(0) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs750365142 | c.283N>T | p.Arg95Trp | p.R95W | Q96H12 | protein_coding | deleterious(0.02) | benign(0.265) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs367876098 | c.451N>A | p.Asp151Asn | p.D151N | Q96H12 | protein_coding | deleterious_low_confidence(0) | benign(0.021) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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