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Gene: MS4A15 |
Gene summary for MS4A15 |
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Gene information | Species | Human | Gene symbol | MS4A15 | Gene ID | 219995 |
Gene name | membrane spanning 4-domains A15 | |
Gene Alias | MS4A15 | |
Cytomap | 11q12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N5U1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219995 | MS4A15 | TD9 | Human | Lung | IAC | 4.93e-02 | 4.75e-01 | 0.088 |
219995 | MS4A15 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.67e-02 | 5.91e-01 | -0.1406 |
219995 | MS4A15 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 4.21e-19 | 8.36e-01 | -0.2116 |
219995 | MS4A15 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 7.67e-09 | 9.07e-01 | -0.1941 |
219995 | MS4A15 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 5.82e-09 | 8.69e-01 | -0.2107 |
219995 | MS4A15 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.62e-15 | 8.89e-01 | -0.2119 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MS4A15 | SNV | Missense_Mutation | novel | c.306N>G | p.Ile102Met | p.I102M | Q8N5U1 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
MS4A15 | insertion | Frame_Shift_Ins | novel | c.171_172insAAAAG | p.Pro58LysfsTer12 | p.P58Kfs*12 | Q8N5U1 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
MS4A15 | insertion | Frame_Shift_Ins | novel | c.172_173insCATCTAGTGGATGTTTGTGGTTTAACAAGCT | p.Asp59SerfsTer11 | p.D59Sfs*11 | Q8N5U1 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
MS4A15 | insertion | In_Frame_Ins | novel | c.111_112insGTGGCTGGTAATTCTTGTCCTTTGCCAAGT | p.Pro37_Gly38insValAlaGlyAsnSerCysProLeuProSer | p.P37_G38insVAGNSCPLPS | Q8N5U1 | protein_coding | TCGA-AN-A0AL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
MS4A15 | SNV | Missense_Mutation | novel | c.338N>A | p.Gly113Glu | p.G113E | Q8N5U1 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
MS4A15 | SNV | Missense_Mutation | novel | c.340N>A | p.Gly114Arg | p.G114R | Q8N5U1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
MS4A15 | SNV | Missense_Mutation | novel | c.526C>T | p.Leu176Phe | p.L176F | Q8N5U1 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MS4A15 | SNV | Missense_Mutation | c.271N>A | p.Val91Met | p.V91M | Q8N5U1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MS4A15 | SNV | Missense_Mutation | novel | c.445N>C | p.Ala149Pro | p.A149P | Q8N5U1 | protein_coding | tolerated(0.19) | benign(0.007) | TCGA-G4-6297-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | PD |
MS4A15 | SNV | Missense_Mutation | rs374526227 | c.77C>T | p.Pro26Leu | p.P26L | Q8N5U1 | protein_coding | tolerated(0.28) | probably_damaging(0.998) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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