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Gene: MS4A12 |
Gene summary for MS4A12 |
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Gene information | Species | Human | Gene symbol | MS4A12 | Gene ID | 54860 |
Gene name | membrane spanning 4-domains A12 | |
Gene Alias | Ms4a10 | |
Cytomap | 11q12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NXJ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54860 | MS4A12 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.26e-04 | -2.12e-01 | 0.0155 |
54860 | MS4A12 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.69e-12 | 1.06e+00 | -0.1954 |
54860 | MS4A12 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.84e-02 | 1.02e+00 | -0.2196 |
54860 | MS4A12 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.35e-04 | 4.63e-01 | -0.1464 |
54860 | MS4A12 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.27e-15 | 2.26e+00 | -0.2061 |
54860 | MS4A12 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.14e-03 | -2.12e-01 | 0.096 |
54860 | MS4A12 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.25e-05 | -2.12e-01 | 0.0674 |
54860 | MS4A12 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.53e-02 | -2.02e-01 | 0.294 |
54860 | MS4A12 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.20e-02 | -2.08e-01 | 0.3859 |
54860 | MS4A12 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.62e-04 | -2.12e-01 | 0.3005 |
54860 | MS4A12 | A002-C-010 | Human | Colorectum | FAP | 9.36e-06 | -2.09e-01 | 0.242 |
54860 | MS4A12 | A002-C-201 | Human | Colorectum | FAP | 4.25e-05 | -2.12e-01 | 0.0324 |
54860 | MS4A12 | A002-C-203 | Human | Colorectum | FAP | 9.04e-05 | -2.06e-01 | 0.2786 |
54860 | MS4A12 | A002-C-205 | Human | Colorectum | FAP | 1.12e-02 | -2.01e-01 | -0.1236 |
54860 | MS4A12 | A002-C-116 | Human | Colorectum | FAP | 4.02e-02 | -2.01e-01 | -0.0452 |
54860 | MS4A12 | A014-C-008 | Human | Colorectum | FAP | 3.72e-02 | -2.12e-01 | -0.191 |
54860 | MS4A12 | F034 | Human | Colorectum | FAP | 8.62e-04 | -2.12e-01 | -0.0665 |
54860 | MS4A12 | F072B | Human | Colorectum | FAP | 3.85e-03 | -2.12e-01 | 0.257 |
54860 | MS4A12 | CRC-1-8810 | Human | Colorectum | CRC | 4.25e-05 | -2.12e-01 | 0.6257 |
54860 | MS4A12 | CRC-3-11773 | Human | Colorectum | CRC | 4.07e-04 | -2.12e-01 | 0.2564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MS4A12 | SNV | Missense_Mutation | rs111546873 | c.464N>A | p.Arg155His | p.R155H | Q9NXJ0 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MS4A12 | insertion | Frame_Shift_Ins | novel | c.313_314insATTTA | p.Phe105TyrfsTer9 | p.F105Yfs*9 | Q9NXJ0 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MS4A12 | SNV | Missense_Mutation | novel | c.128C>T | p.Ala43Val | p.A43V | Q9NXJ0 | protein_coding | tolerated(0.35) | benign(0.006) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MS4A12 | SNV | Missense_Mutation | c.764N>A | p.Pro255His | p.P255H | Q9NXJ0 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MS4A12 | SNV | Missense_Mutation | c.584N>T | p.Ala195Val | p.A195V | Q9NXJ0 | protein_coding | tolerated(0.07) | benign(0.153) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MS4A12 | SNV | Missense_Mutation | c.749N>T | p.Ala250Val | p.A250V | Q9NXJ0 | protein_coding | tolerated(0.24) | benign(0.085) | TCGA-D5-6538-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | SD | |
MS4A12 | SNV | Missense_Mutation | novel | c.72N>A | p.Ser24Arg | p.S24R | Q9NXJ0 | protein_coding | tolerated(0.33) | benign(0.006) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MS4A12 | SNV | Missense_Mutation | novel | c.488N>T | p.Gly163Val | p.G163V | Q9NXJ0 | protein_coding | deleterious(0.03) | probably_damaging(0.983) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MS4A12 | SNV | Missense_Mutation | c.44N>T | p.Thr15Ile | p.T15I | Q9NXJ0 | protein_coding | deleterious(0) | possibly_damaging(0.863) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MS4A12 | SNV | Missense_Mutation | c.8C>T | p.Ser3Leu | p.S3L | Q9NXJ0 | protein_coding | deleterious(0.04) | benign(0.211) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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