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Gene: MRPS31 |
Gene summary for MRPS31 |
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Gene information | Species | Human | Gene symbol | MRPS31 | Gene ID | 10240 |
Gene name | mitochondrial ribosomal protein S31 | |
Gene Alias | IMOGN38 | |
Cytomap | 13q14.11 | |
Gene Type | protein-coding | GO ID | GO:0000313 | UniProtAcc | Q92665 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10240 | MRPS31 | LZE2T | Human | Esophagus | ESCC | 4.20e-04 | 3.19e-01 | 0.082 |
10240 | MRPS31 | LZE4T | Human | Esophagus | ESCC | 6.55e-04 | 1.66e-01 | 0.0811 |
10240 | MRPS31 | LZE5T | Human | Esophagus | ESCC | 1.43e-05 | 3.45e-01 | 0.0514 |
10240 | MRPS31 | LZE7T | Human | Esophagus | ESCC | 2.32e-06 | 1.88e-01 | 0.0667 |
10240 | MRPS31 | LZE20T | Human | Esophagus | ESCC | 1.58e-04 | 2.16e-01 | 0.0662 |
10240 | MRPS31 | LZE24T | Human | Esophagus | ESCC | 1.27e-13 | 2.53e-01 | 0.0596 |
10240 | MRPS31 | P1T-E | Human | Esophagus | ESCC | 2.11e-14 | 4.15e-01 | 0.0875 |
10240 | MRPS31 | P2T-E | Human | Esophagus | ESCC | 5.60e-27 | 4.29e-01 | 0.1177 |
10240 | MRPS31 | P4T-E | Human | Esophagus | ESCC | 4.47e-24 | 5.34e-01 | 0.1323 |
10240 | MRPS31 | P5T-E | Human | Esophagus | ESCC | 2.39e-09 | 1.36e-01 | 0.1327 |
10240 | MRPS31 | P8T-E | Human | Esophagus | ESCC | 1.14e-23 | 5.22e-01 | 0.0889 |
10240 | MRPS31 | P9T-E | Human | Esophagus | ESCC | 9.92e-18 | 3.45e-01 | 0.1131 |
10240 | MRPS31 | P10T-E | Human | Esophagus | ESCC | 4.71e-24 | 4.53e-01 | 0.116 |
10240 | MRPS31 | P11T-E | Human | Esophagus | ESCC | 9.97e-03 | 1.41e-01 | 0.1426 |
10240 | MRPS31 | P12T-E | Human | Esophagus | ESCC | 1.46e-13 | 1.84e-01 | 0.1122 |
10240 | MRPS31 | P15T-E | Human | Esophagus | ESCC | 5.44e-15 | 2.51e-01 | 0.1149 |
10240 | MRPS31 | P16T-E | Human | Esophagus | ESCC | 7.26e-14 | 2.41e-01 | 0.1153 |
10240 | MRPS31 | P17T-E | Human | Esophagus | ESCC | 4.80e-11 | 4.65e-01 | 0.1278 |
10240 | MRPS31 | P19T-E | Human | Esophagus | ESCC | 5.65e-07 | 3.67e-01 | 0.1662 |
10240 | MRPS31 | P20T-E | Human | Esophagus | ESCC | 1.43e-11 | 3.05e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPS31 | SNV | Missense_Mutation | c.1152N>T | p.Lys384Asn | p.K384N | Q92665 | protein_coding | deleterious(0.03) | benign(0.107) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPS31 | SNV | Missense_Mutation | c.505N>C | p.Asp169His | p.D169H | Q92665 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
MRPS31 | SNV | Missense_Mutation | c.469N>C | p.Ala157Pro | p.A157P | Q92665 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-E2-A1LI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MRPS31 | insertion | Nonsense_Mutation | novel | c.663_664insATTATAATTTGTAATTAAACATTGCAGTGTTTTCTG | p.Arg221_Pro222insIleIleIleCysAsnTerThrLeuGlnCysPheLeu | p.R221_P222insIIICN*TLQCFL | Q92665 | protein_coding | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | ||
MRPS31 | SNV | Missense_Mutation | rs757626748 | c.251C>T | p.Thr84Ile | p.T84I | Q92665 | protein_coding | tolerated(0.12) | benign(0.018) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
MRPS31 | SNV | Missense_Mutation | novel | c.685N>C | p.Asp229His | p.D229H | Q92665 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
MRPS31 | SNV | Missense_Mutation | novel | c.652N>C | p.Val218Leu | p.V218L | Q92665 | protein_coding | tolerated(0.35) | benign(0.079) | TCGA-JW-A5VG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
MRPS31 | insertion | In_Frame_Ins | rs779113623 | c.196_197insGCATAT | p.Ile66delinsSerIlePhe | p.I66delinsSIF | Q92665 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
MRPS31 | insertion | Frame_Shift_Ins | novel | c.1151dupA | p.Asp385GlyfsTer7 | p.D385Gfs*7 | Q92665 | protein_coding | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MRPS31 | SNV | Missense_Mutation | novel | c.297N>T | p.Leu99Phe | p.L99F | Q92665 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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