Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MRPS18B

Gene summary for MRPS18B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MRPS18B

Gene ID

28973

Gene namemitochondrial ribosomal protein S18B
Gene AliasC6orf14
Cytomap6p21.33
Gene Typeprotein-coding
GO ID

GO:0006412

UniProtAcc

B0S7P4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
28973MRPS18BHTA11_3410_2000001011HumanColorectumAD3.30e-103.42e-010.0155
28973MRPS18BHTA11_2487_2000001011HumanColorectumSER7.31e-083.74e-01-0.1808
28973MRPS18BHTA11_1938_2000001011HumanColorectumAD1.17e-145.81e-01-0.0811
28973MRPS18BHTA11_78_2000001011HumanColorectumAD6.71e-084.52e-01-0.1088
28973MRPS18BHTA11_347_2000001011HumanColorectumAD1.61e-226.51e-01-0.1954
28973MRPS18BHTA11_3361_2000001011HumanColorectumAD9.89e-064.59e-01-0.1207
28973MRPS18BHTA11_83_2000001011HumanColorectumSER8.57e-075.12e-01-0.1526
28973MRPS18BHTA11_696_2000001011HumanColorectumAD2.33e-246.09e-01-0.1464
28973MRPS18BHTA11_866_2000001011HumanColorectumAD7.92e-134.53e-01-0.1001
28973MRPS18BHTA11_1391_2000001011HumanColorectumAD5.47e-216.85e-01-0.059
28973MRPS18BHTA11_2992_2000001011HumanColorectumSER2.64e-034.94e-01-0.1706
28973MRPS18BHTA11_5212_2000001011HumanColorectumAD4.12e-023.70e-01-0.2061
28973MRPS18BHTA11_5216_2000001011HumanColorectumSER1.18e-045.33e-01-0.1462
28973MRPS18BHTA11_546_2000001011HumanColorectumAD1.08e-128.66e-01-0.0842
28973MRPS18BHTA11_7862_2000001011HumanColorectumAD2.81e-116.29e-01-0.0179
28973MRPS18BHTA11_866_3004761011HumanColorectumAD3.95e-266.46e-010.096
28973MRPS18BHTA11_4255_2000001011HumanColorectumSER1.67e-055.56e-010.0446
28973MRPS18BHTA11_8622_2000001021HumanColorectumSER1.53e-065.74e-010.0528
28973MRPS18BHTA11_7663_2000001011HumanColorectumSER5.56e-054.91e-010.0131
28973MRPS18BHTA11_10623_2000001011HumanColorectumAD4.65e-178.45e-01-0.0177
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:014005313EsophagusESCCmitochondrial gene expression93/8552108/187231.96e-182.03e-1693
GO:003254314EsophagusESCCmitochondrial translation68/855276/187231.02e-156.86e-1468
GO:0032543LiverCirrhoticmitochondrial translation40/463476/187231.61e-074.29e-0640
GO:0140053LiverCirrhoticmitochondrial gene expression49/4634108/187232.35e-064.31e-0549
GO:01400531LiverHCCmitochondrial gene expression82/7958108/187231.49e-127.20e-1182
GO:00325431LiverHCCmitochondrial translation62/795876/187232.95e-121.34e-1062
GO:01400533Oral cavityOSCCmitochondrial gene expression78/7305108/187232.37e-129.86e-1178
GO:00325434Oral cavityOSCCmitochondrial translation59/730576/187237.21e-122.70e-1059
GO:003254313Oral cavityLPmitochondrial translation43/462376/187232.85e-091.26e-0743
GO:014005312Oral cavityLPmitochondrial gene expression53/4623108/187233.54e-081.27e-0653
GO:00325436SkincSCCmitochondrial translation47/486476/187234.70e-112.22e-0947
GO:01400535SkincSCCmitochondrial gene expression56/4864108/187238.06e-092.56e-0756
GO:01400536ThyroidPTCmitochondrial gene expression51/5968108/187236.04e-043.83e-0351
GO:00325437ThyroidPTCmitochondrial translation38/596876/187237.52e-044.67e-0338
GO:014005314ThyroidATCmitochondrial gene expression51/6293108/187232.26e-031.06e-0251
GO:003254315ThyroidATCmitochondrial translation38/629376/187232.26e-031.06e-0238
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0520325EsophagusESCCViral carcinogenesis137/4205204/84652.47e-071.88e-069.62e-07137
hsa0520335EsophagusESCCViral carcinogenesis137/4205204/84652.47e-071.88e-069.62e-07137
hsa05203LiverCirrhoticViral carcinogenesis76/2530204/84651.34e-024.20e-022.59e-0276
hsa052031LiverCirrhoticViral carcinogenesis76/2530204/84651.34e-024.20e-022.59e-0276
hsa052032LiverHCCViral carcinogenesis117/4020204/84652.68e-038.98e-035.00e-03117
hsa052033LiverHCCViral carcinogenesis117/4020204/84652.68e-038.98e-035.00e-03117
hsa052038Oral cavityOSCCViral carcinogenesis124/3704204/84655.57e-073.28e-061.67e-06124
hsa0520314Oral cavityOSCCViral carcinogenesis124/3704204/84655.57e-073.28e-061.67e-06124
hsa0520324Oral cavityLPViral carcinogenesis90/2418204/84651.20e-061.38e-058.89e-0690
hsa0520334Oral cavityLPViral carcinogenesis90/2418204/84651.20e-061.38e-058.89e-0690
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MRPS18BSNVMissense_Mutationrs763959905c.265N>Tp.Arg89Trpp.R89WQ9Y676protein_codingdeleterious(0)possibly_damaging(0.849)TCGA-A1-A0SE-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
MRPS18BSNVMissense_Mutationnovelc.328G>Ap.Asp110Asnp.D110NQ9Y676protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AC-A3W6-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
MRPS18BSNVMissense_Mutationnovelc.178N>Ap.Glu60Lysp.E60KQ9Y676protein_codingtolerated(0.33)benign(0.115)TCGA-GM-A3NW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilSD
MRPS18BSNVMissense_Mutationc.73N>Ap.Val25Ilep.V25IQ9Y676protein_codingtolerated(0.07)benign(0.251)TCGA-DG-A2KK-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinSD
MRPS18BSNVMissense_Mutationc.589G>Cp.Asp197Hisp.D197HQ9Y676protein_codingtolerated(0.05)benign(0.417)TCGA-Q1-A73O-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
MRPS18BSNVMissense_Mutationnovelc.632N>Ap.Arg211Lysp.R211KQ9Y676protein_codingtolerated(0.41)benign(0.056)TCGA-VS-A8QA-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
MRPS18BSNVMissense_Mutationrs140805833c.212N>Ap.Arg71Hisp.R71HQ9Y676protein_codingtolerated(0.1)possibly_damaging(0.456)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MRPS18BSNVMissense_Mutationnovelc.106N>Tp.Ala36Serp.A36SQ9Y676protein_codingtolerated(0.12)benign(0.003)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
MRPS18BSNVMissense_Mutationrs144633864c.644N>Ap.Arg215Hisp.R215HQ9Y676protein_codingdeleterious(0.01)probably_damaging(0.996)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
MRPS18BSNVMissense_Mutationc.346G>Cp.Asp116Hisp.D116HQ9Y676protein_codingtolerated(0.3)probably_damaging(1)TCGA-AP-A0LF-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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