|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: MRPS11 |
Gene summary for MRPS11 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MRPS11 | Gene ID | 64963 |
| Gene name | mitochondrial ribosomal protein S11 | |
| Gene Alias | HCC-2 | |
| Cytomap | 15q25.3 | |
| Gene Type | protein-coding | GO ID | GO:0000028 | UniProtAcc | P82912 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64963 | MRPS11 | LZE4T | Human | Esophagus | ESCC | 1.67e-10 | 3.03e-01 | 0.0811 |
| 64963 | MRPS11 | LZE5T | Human | Esophagus | ESCC | 2.49e-02 | 3.71e-01 | 0.0514 |
| 64963 | MRPS11 | LZE7T | Human | Esophagus | ESCC | 8.09e-20 | 8.63e-01 | 0.0667 |
| 64963 | MRPS11 | LZE8T | Human | Esophagus | ESCC | 7.74e-08 | 2.72e-01 | 0.067 |
| 64963 | MRPS11 | LZE20T | Human | Esophagus | ESCC | 1.69e-02 | 1.45e-01 | 0.0662 |
| 64963 | MRPS11 | LZE22T | Human | Esophagus | ESCC | 1.05e-03 | 3.71e-01 | 0.068 |
| 64963 | MRPS11 | LZE24T | Human | Esophagus | ESCC | 3.17e-13 | 3.61e-01 | 0.0596 |
| 64963 | MRPS11 | LZE21T | Human | Esophagus | ESCC | 1.53e-06 | 5.27e-01 | 0.0655 |
| 64963 | MRPS11 | LZE6T | Human | Esophagus | ESCC | 3.41e-14 | 5.90e-01 | 0.0845 |
| 64963 | MRPS11 | P1T-E | Human | Esophagus | ESCC | 6.48e-13 | 5.47e-01 | 0.0875 |
| 64963 | MRPS11 | P2T-E | Human | Esophagus | ESCC | 2.46e-29 | 5.08e-01 | 0.1177 |
| 64963 | MRPS11 | P4T-E | Human | Esophagus | ESCC | 1.35e-42 | 8.94e-01 | 0.1323 |
| 64963 | MRPS11 | P5T-E | Human | Esophagus | ESCC | 3.78e-20 | 2.76e-01 | 0.1327 |
| 64963 | MRPS11 | P8T-E | Human | Esophagus | ESCC | 7.40e-33 | 6.37e-01 | 0.0889 |
| 64963 | MRPS11 | P9T-E | Human | Esophagus | ESCC | 5.19e-24 | 6.79e-01 | 0.1131 |
| 64963 | MRPS11 | P10T-E | Human | Esophagus | ESCC | 2.92e-47 | 7.10e-01 | 0.116 |
| 64963 | MRPS11 | P11T-E | Human | Esophagus | ESCC | 9.76e-12 | 4.79e-01 | 0.1426 |
| 64963 | MRPS11 | P12T-E | Human | Esophagus | ESCC | 4.51e-37 | 6.12e-01 | 0.1122 |
| 64963 | MRPS11 | P15T-E | Human | Esophagus | ESCC | 3.62e-22 | 5.01e-01 | 0.1149 |
| 64963 | MRPS11 | P16T-E | Human | Esophagus | ESCC | 1.88e-29 | 5.94e-01 | 0.1153 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
| GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
| GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
| GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
| GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
| GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
| GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
| GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
| GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
| GO:0022618111 | Esophagus | ESCC | ribonucleoprotein complex assembly | 159/8552 | 220/18723 | 8.19e-16 | 5.71e-14 | 159 |
| GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
| GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
| GO:0042255111 | Esophagus | ESCC | ribosome assembly | 50/8552 | 61/18723 | 5.66e-09 | 1.17e-07 | 50 |
| GO:00004623 | Esophagus | ESCC | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 32/8552 | 37/18723 | 2.96e-07 | 4.23e-06 | 32 |
| GO:00427697 | Esophagus | ESCC | DNA damage response, detection of DNA damage | 12/8552 | 13/18723 | 6.18e-04 | 3.32e-03 | 12 |
| GO:0000028111 | Esophagus | ESCC | ribosomal small subunit assembly | 16/8552 | 19/18723 | 6.45e-04 | 3.43e-03 | 16 |
| GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
| GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
| GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
| GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
| hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
| hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
| hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
| hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
| hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
| hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
| hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
| hsa03010210 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
| hsa0301038 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MRPS11 | insertion | Nonsense_Mutation | novel | c.149_150insCCCACCGCCTCTTGTATTTCCTTCTTAACATTCATC | p.Glu50delinsAspProProProLeuValPheProSerTerHisSerSer | p.E50delinsDPPPLVFPS*HSS | P82912 | protein_coding | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| MRPS11 | SNV | Missense_Mutation | rs774896757 | c.353N>A | p.Arg118Gln | p.R118Q | P82912 | protein_coding | tolerated(0.14) | benign(0.188) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MRPS11 | SNV | Missense_Mutation | rs149047976 | c.352N>T | p.Arg118Trp | p.R118W | P82912 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MRPS11 | SNV | Missense_Mutation | rs372417211 | c.490N>A | p.Gly164Arg | p.G164R | P82912 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
| MRPS11 | SNV | Missense_Mutation | c.187T>C | p.Tyr63His | p.Y63H | P82912 | protein_coding | tolerated(0.12) | possibly_damaging(0.535) | TCGA-G4-6303-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
| MRPS11 | SNV | Missense_Mutation | rs149047976 | c.352C>T | p.Arg118Trp | p.R118W | P82912 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MRPS11 | SNV | Missense_Mutation | c.305N>A | p.Ala102Asp | p.A102D | P82912 | protein_coding | tolerated(0.22) | possibly_damaging(0.521) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MRPS11 | SNV | Missense_Mutation | novel | c.152N>G | p.Gln51Arg | p.Q51R | P82912 | protein_coding | tolerated(0.18) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MRPS11 | SNV | Missense_Mutation | rs372417211 | c.490N>A | p.Gly164Arg | p.G164R | P82912 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
| MRPS11 | SNV | Missense_Mutation | novel | c.578N>C | p.Lys193Thr | p.K193T | P82912 | protein_coding | deleterious(0) | benign(0.105) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |